| Study Director |
William W. Seeley, MD (PI: Bruce Miller, MD) |
| Sponsor |
NIH and Larry L. Hillblom |
| Official Study Title |
Anterior Cingulate, Insular and Frontoinsular Vulnerability in FTLD and AD |
| Conditions Studied |
FTD, AD and other closely related neurological disorders
including CBD, PSP, and ALS with dementia. |
| Purpose |
The purpose of this study is to examine how brain
activity relates to autonomic responses in healthy subjects and patients with FTD, AD and other closely
related nuerodegenerative diseases. |
| Inclusion Criteria |
Subjects must be enrolled in either the FTD
study or ADRC study. Subjects must meet criteria for
one of the neurodegenerative diseases mentioned above, unless participating as a control. Subjects must also
have an MMSE score above 15. |
| Exclusion Criteria |
Past or current history of alcohol abuse, substance abuse, head trauma (with loss of consciousness
greater than 15 minutes), intraparenchymal brain tumor, multiple sclerosis, epilepsy, parkinsonism,
hydrocephalus, intracerebral hemorrhage, schizophrenia, or bipolar disorder. Corticol more than four
lacunar strokes, intraparenchymal structural lesion or prominent periventricular white matter
disease.
Current history of pacemaker, ferromagnetic matter in body, respiratory failure (oxygen-dependent),
unipolar depression, anxiety disorder and claustrophobia also exclude subjects from participating |
| Testing |
FMRI and physiological measurements take approximately 45-60 minutes. |
| Materials Needed Prior to Evaluation |
None |
| Costs |
No costs will be charged for any of the study proceedures. Parking
will be validated for Millberry Parking Garage for study visit. |
