| Study Director |
Bruce Miller, MD (PI: Michael Weiner, MD) |
| Sponsor |
National Institute on Aging |
| Official Study Title |
Prediction of Cognitive Decline |
| Conditions Studied |
Mild Cognitive Impairment and Healthy Adults |
| Purpose |
The aim of this study is to identify predictors of cognitive
decline and dementia. Subjects will receive three MRI brain scans during the first year of the
study, and neuropsychological testing will evaluate different aspects of cognition including
memory and executive functioning. This study will determine how well MRI and cognitive measures
predict those at greatest risk for cognitive and functional decline. These results will
hopefully lead to earlier diagnosis and treatment of neurodegenerative diseases. |
| Inclusion Criteria |
Over 60 years old, normals, individuals with complaints,
or scores below age/sex/education adjusted norm on ANY of the memory or executive function
tests in our battery; NO dementia |
| Exclusion Criteria |
Dementia, claustrophobia, ferromagnetic implants or pacemakers,
history of TIAs, stroke or MRI evidence of cortical stroke, untreated hypertension, uncontrolled
diabetes, psychiatric illness, other neurological diseases that are associated with impaired
cognition (i.e., MS, epilepsy, Parkinson's Disease), current drug or alcohol abuse, Hachinski
> 4, cognitive impairment that appears secondary to depression |
| Testing |
3-4 hours of neuropsychological testing (annually), blood
draw at first visit, 2 hour MRI at each visit |
| Frequency of Visits |
Initial Visit, and then in 6 months and 1 year, (annually for up to
5 years) |
| Materials Needed Prior to Evaluation |
Medical records and physician's referral |
