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Observational Studies             Treatment Trials

Taste and Eating Behaviors in Dementia

Study Director Brandy R. Matthews, MD (PI: Bruce Miller, MD)
Sponsor  
Recruiting? Yes
Official Study Title Taste Preferences and Dysregulation of Feeding in Frontotemporal Dementia
Conditions Studied

Frontotemporal Dementia (FTD)
Semantic Dementia (SD)
Primary Progressive Aphasia (PPA)
Frontotemporal Dementia with Amyotrophic Lateral Sclerosis (FTD-ALS)
Corticobasal Degeneration (CBD)
Alzheimer's Disease (AD)
Healthy Adults

Purpose Isolated brain pathology may lead to selective deficits in the experience of tastes, smells and flavors while leaving the ability to discriminate between these stimuli intact. Our primary aim is to investigate the neurobiological basis of emotional processing and the associated hormonal fluctuations through subjects' responses to tastes and flavors. Findings could lead to a better understanding of the neurobiological substrates for emotion and result in increased knowledge about the early changes in diseases that affect the emotional system such as Alzheimer’s Disease, Frontotemporal Dementia and other neurodegenerative diseases. Such findings may contribute to improved methods for early diagnosis and early intervention when feeding dysregulation is endangering general health.
Eligibility  
Inclusion Criteria Enrollment into the FTD study
Exclusion Criteria Diabetes, dysphagia
What is Involved?  
Testing Standard breakfast with serial blood draws through IV on first morning, monitered sandwich lunches on 2 consecutive days, body measurements and solutions taste test
Frequency of Visits Portions of 3 days associated with yearly research visit
Contact Information  
Coordinator TBD
Phone  
Materials Needed Prior to Evaluation None
Costs None

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