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Life History Matters

Zachary Miller loves talking to his patients about their childhood. He believes that the clues to some neurodegenerative diseases have roots in a person’s early years of life. Did your mother have a normal pregnancy? Were you born on time? Did you enjoy reading? Were you ever tutored in math? Are you left-handed? And on and on it goes, patching together dozens of bits of life history to make sense of why an aging brain may be more vulnerable to specific types of dementia. Read more

The Lost Wife

She stares at me, owl-eyed, empty. There is no embarrassment when time ticks on. She stares. A sound breaks her gaze and her eyes lock on to a new target. She is nowhere to be found. The old her, that is. The woman who showed such immense joy and love as a mother is gone. Her husband moves her around the streets of their city like he is pulling a 100-pound weight on wheels in his hand. She goes with the flow. He and the children have built a life around this new woman – this wife and mother who is lost to a genetic disease that has stolen everything human about her. She is only 38 years old. She no longer speaks. She stares. She is led to the bathroom, to the shower, to the table where they put a fork or spoon in her hand for her to eat. Read more

The Puzzle of Language

There was an unspoken script in a young girl’s life growing up in a cultured family in Brescia, Italy in the 1970s that she would go on to a university to study the humanities. But this young girl had no interest in the arts or classics – she did poorly in Latin and Greek – and she had her sites set for medicine. Her mom grew up in a transitional generation in the early 1960s but observed feminism through a telescope. She knew she wanted something different for her only daughter, but she was still trapped in the tradition that etched out life for an Italian girl. Read more

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