Tag Archives: ALS

Finding the Needle in the Chromosome

Collaboration between the UCSF Memory and Aging Center and Mayo Clinic identifies a new single gene cause of Lou Gehrig’s disease and frontotemporal dementia

Rumors started buzzing about five years ago when six different groups of scientists began narrowing in on a region of chromosome 9 to explain what they were seeing in the clinic. Frontotemporal dementia (FTD), a behavioral and cognitive neurodegenerative disease, and amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), a neuromuscular degenerative disease, often run in the same family and may even appear in the same person. Narrowing down the right chromosome was a start, but chromosome 9 has 1534 genes on it. How do you find the right one? Read more

A Gene for Lou Gehrig’s Disease and Frontotemporal Dementia Identified

Frontotemporal dementia and amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease – two fatal neurodegenerative disease with distinct symptoms – are triggered by a common mutation in many cases, according to researchers who say they have identified the mutated gene.

In the study, reported in the September 21 online issue of Neuron, the scientists described the discovery of a genetic mutation that is accountable for almost 12 percent of familial FTD and more than 22 percent of familial ALS samples studied. Read more

Single Gene Implicated in FTD/ALS

Researchers have recently found a single gene cause for two neurodegenerative conditions that are distinct but related, frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In an online issue of the scientific journal Neuron, researchers at Mayo Clinic in Florida, in collaboration with the UCSF Memory and Aging Center and others, report that the newly discovered genetic abnormality is responsible for a significant proportion of families with both FTD and ALS (FTD/ALS) and many families where the dominant syndrome is either familial FTD or familial ALS. Less commonly, it is associated with sporadic FTD or sporadic ALS, meaning occurrences of FTD or ALS without a family history. Read more