Tag Archives: CBD

Seeing the Data with New Eyes

The data suggest that it is time to redefine the clinical diagnosis of corticobasal degeneration

Corticobasal degeneration (CBD) is a progressive neurological disorder first described in 1968 by Rebeiz, Richardson and Kolodny. Yet, only recently has there been a systematic effort to reliably diagnose this condition. Nothing can be more discouraging than to have a loved one misdiagnosed during life. Furthermore, it is now known that CBD is caused by abnormal accumulations of the protein tau and, as disease-specific therapies are emerging, getting the right diagnosis has become critically important. Read more

Consortium to Study Tauopathies: Finding novel solutions through collaboration

One year ago, a consortium of just over 20 international clinician-scientists came together to understand, and ultimately treat and cure, tau-related disorders (tauopathies) including progressive supranuclear palsy (PSP), frontotemporal dementia with parkinsonism (FTD-P) and corticobasal degeneration (CBD). Read more

Unfolding the Role of Tau

The pathological hallmark of tauopathies still holds mysteries

Normal tau protein is found in the axons of healthy neurons and is critical to the healthy functioning of a normal nervous system. It stabilizes the microtubules that form the supportive framework of the neuron and provide the tracks for oxygen proteins and glucose to move within the neuron. Changes in the tau protein can lead to instability in the microtubules, which makes it difficult for neurons to survive.
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