Tag Archives: tauopathy

Old and New: Understanding Social Memories in bvFTD

After 20 years of marriage, after raising two kids, after building a farm and tending horses and dogs, Caroline knew this much about the man she loves: he is tender-hearted, fun-loving and never let stress land too long on his shoulders. Four years ago, the old Nick somehow morphed into a new guy, one who is not so patient. A guy who lost his social edge and seems unable to read faces. He is tired and withdrawn. “He’s just not the same guy,” she says. “I want him back.” Read more

Finding Treatments, One at a Time

A new clinical trial for people with progressive supranuclear palsy may open the door for other treatments

Progressive supranuclear palsy (PSP) is a degenerative brain disease leading to difficulties with walking and balance, problems with eye movements, changes in behavior and executive control, difficulty with speech and swallowing, and dementia. PSP, corticobasal degeneration (CBD) and some of the frontotemporal dementias (FTD) are tauopathies—diseases associated with the abnormal accumulation of the protein tau. It is likely that whether one presents with PSP, CBD or FTD depends in part on the location in the brain of these microscopic changes, although individual differences may play an important role as well. Read more

Seeing the Data with New Eyes

The data suggest that it is time to redefine the clinical diagnosis of corticobasal degeneration

Corticobasal degeneration (CBD) is a progressive neurological disorder first described in 1968 by Rebeiz, Richardson and Kolodny. Yet, only recently has there been a systematic effort to reliably diagnose this condition. Nothing can be more discouraging than to have a loved one misdiagnosed during life. Furthermore, it is now known that CBD is caused by abnormal accumulations of the protein tau and, as disease-specific therapies are emerging, getting the right diagnosis has become critically important. Read more