Possible vCJD

Criteria for Possible Variant Jakob-Creutzfeldt Disease
(UK DoH 2003)

1. Progressive neuropsychiatric disorder for more than 6 months
2. Routine investigations do not suggest an alternative diagnosis
3. No history of potential iatrogenic exposure
4. At least 4 of the following 5 symptoms:
   1. Early psychiatric symptoms (depression, anxiety, apathy withdrawal, delusions)
   2. Persistent painful sensory symptoms (including both frank pain and/or unpleasant dysaesthesia)
   3. Ataxia
   4. Myoclonus, chorea or dystonia
   5. Dementia
5. EEG does not show the typical appearance of sporadic CJD or no EEG has been performed