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Probable sCJD (WHO)

Criteria for Probable Sporadic Jakob-Creutzfeldt Disease
(WHO 1998)

  1. Progressive dementia
  2. At least 2 of the following 4 symptoms:
    1. Myoclonus
    2. Pyramidal/extrapyramidal
    3. Visual or cerebellar
    4. Akinetic mutism
  3. Positive EEG (periodic epileptiform discharges)
  4. AND/OR positive 14-3-3 protein result and < 2 year disease duration
  5. Routine investigations do not suggest an alternative diagnosis
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