Prion Topology and Toxicity

Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) [1] now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.

Citation: Aguzzi A, Steele AD. Prion Topology and Toxicity [2]. Cell. 2009;137:994-996.