Familial Progressive Supranuclear Palsy (FamPSP)

Purpose of the Study

The goal of this study is to identify rare genetic variants as risk factors for progressive supranuclear palsy (PSP). By studying patients with PSP and their relatives affected by related conditions, we hope to identify genes that are involved in PSP and related disorders.

Study Details

This study involves one visit to the UCSF Memory and Aging Center in San Francisco, California for approximately five hours. Testing includes neurological and physical examinations, interview with the study partner, cognitive testing, detailed family history, blood and/or saliva specimen collection for genetic analysis, behavioral testing and questionnaires for both the participant and study partner. There is no cost to participate in the study, and some travel expenses may be reimbursed.

  • Inclusion Criteria: Participants must meet criteria for progressive supranuclear palsy (PSP) with a first-degree blood relative affected by a neurological or psychiatric disorder (e.g., PSP or related disorders, dementia, Parkinson’s, psychiatric illness, as determined by review of medical records and family history). Familial participants must be either affected by a neurological or psychiatric disorder or an unaffected first-degree relative. All participants must be at least 18 years of age and willing to undergo testing procedures.
  • Exclusion criteria: PSP patients without any positive family history of parkinsonism, dementia, or neuropsychiatric disorder.

Contact Information

If you are interested in participating in this trial or have any questions, please contact the study coordinator, Nancy Cai, at 415.502.7640 or Nancy.Cai@ucsf.edu.