Dementia lacking distinctive histology (DLDH) and other histopathologic forms

Dementia lacking distinctive histopathology (DLDH) is a category where inclusions are absent. This is a very uncommon subtype of FTLD. Some of these patients show significant neuronal loss and gliosis, without Pick bodies, ballooned neurons, neurofibrillary tangles or other inclusion bodies. Unlike FTLD-T findings, these patients show a dramatic reduction of tau protein expression, which likely represents a post-transcriptional effect on tau gene expression, since mRNA for tau remains intact (Zhukareva et al., 2001).