Acetylcholinesterase inhibitors (AChEIs)

Acetylcholinesterase inhibitors, although helpful in AD, do not seem to be effective in managing symptoms of FTD and have been reported to cause agitation in patients with FTD. (Perry & Miller, 2001). They can be dangerous in patients with FTD-MND as they cause increased oral secretions. The most probable explanation for their lack of effectiveness in FTD is that the cholinergic system, in particular the cholinergic neurons in the nucleus basalis of Meynert, are relatively spared in FTD.