Healthy Aging Study

Purpose of the Study

This is a longitudinal study looking at the effects of aging on cognition in older adults. The purpose of the study is to

  1. gain a better understanding of what healthy aging is and
  2. identify the earliest changes associated with degenerative brain disease.

This study also refers healthy volunteers to other Memory and Aging Center projects they may be eligible for.

Study Details

Inclusion criteria: Aged 40–100 with minor or no memory problems

Exclusion criteria: Significant memory problems or diagnosis of a neurodegenerative disease or other major health condition

What to Expect

Testing: A neurological examination, cognitive testing, fasting (no food and drink except water for 12 hours before visit) blood draw for genetics studies, interview with a study partner (someone who knows you well and can comment on any changes over time in your memory, thinking, personality, or behavior) and follow-up appointments every 15 months

The Frequency of Visits: One visit (3–5 hours total) every 15 months longitudinally. Additional 2–3 visits (8–12 hours total) are common for participation in subprojects associated with the Healthy Aging Program including MRI imaging and PET imaging.

Materials Needed Prior to Evaluation: None

Costs: No costs will be charged for any of the study procedures. Parking will be validated for the 1625 Owens Street Garage or 1630 Third Street Garage at the UCSF Mission Bay campus for all study visits. There is no monetary compensation for participation.

Join Our Study

If you are interested in joining the Healthy Aging Program, please complete this online screen. After filling out the online screen, you may be contacted by the study coordinator, Emily Fox to discuss your eligibility. If you have any questions, you can contact Emily at or 415.476.3788.


Additional Healthy Aging Program Studies

  • Aging and Cognitive Decline: a longitudinal study to identify the cognitive mechanisms and neural structures leading to a decline in executive functioning in normal aging
  • Chronic Inflammation in Healthy Aging and MCI: a longitudinal study to investigate possible ways in which inflammation and measures of brain health interact in both healthy aging and populations affected by mild cognitive impairment
  • PET Imaging in Aging Population: a study of protein aggregation in the brain as it relates to brain structure and function in healthy aging

Hillblom Cognitive Aging Symposium

The annual Hillblom Cognitive Aging Symposium is designed to bring together leading researchers in brain aging to share the latest advances in the field. This full-day event highlights the most recent findings between collaborators of the UCSF Hillblom Network for the Prevention of Age-Associated Cognitive Decline as well as special guest lectures from experts in the field of cognitive aging. The talks and Q+A panels at the symposium cover a wide range of topics designed to reflect upon prior knowledge and forge future relationships.

If you would like to watch any of the sessions, click on one of the sessions below and advance to where the particular talk you want to watch starts.

Click Here for the 2016 Morning Session

Talk Title Speaker Video Start Time Video End Time
Hillblom Cognitive Aging Symposium Welcome Joel Kramer, PsyD 3:55 12:25
Serum Klotho is Associated with KLOTHO Variation and Predicts Intrinsic Connectivity in Healthy Aging Jennifer Yokoyama, PhD 12:25 26:00
Teaching an Older Dog Novel Tricks: Cognitive Activity and the Aging Brain Kaitlin Casaletto, PhD 26:00 42:25
The Cognitive Effects of Disrupted Sleep in Healthy Older Adults Christine Walsh, PhD 42:25 1:01:20
Potential for Primary Prevention of Dementia Kristine Yaffe, MD 1:01:20 1:19:00
Nature versus Nurture Discussion Panel All morning speakers 1:19:00 1:43:00


Click Here for the 2016 Afternoon Session

Talk Title Speaker Video Start Time Video End Time
Inflammation and Cognitive Aging: A Role for MCP-1 in Memory Dysfunction Brianne Bettcher, PhD 3:00 21:00
Relationships Between Tau Deposition, Cognition, and β-Amyloid in the Aging Brain Bill Jagust, MD 21:00 46:00
Imaging of Asymptomatic Cerebrovascular Disease Charles DeCarli, MD 46:00 1:15:15
Retinal Imaging Ari Green, MD 1:15:15 1:34:00
Optimal Targets for Aging Research Discussion Panel Previous four speakers 1:34:00 1:55:00
Latino Outreach Serggio Lanata, MD 2:15:40 2:25:30
Cognitive Aging in the Oldest-Old: The 90+ Study Claudia Kawas, PhD 2:25:30 3:02:00
Online Methods for Rapid Behavioral Data Collection in Healthy Older Adults Winston Chiong, MD, PhD 3:02:00 3:20:10
Social Connection in Healthy Aging: Emotional Benefits and Neural Correlates Virginia Sturm, PhD 3:20:10 3:30:30