David Perry, MD

Associate Professor
+1 415 476-8678
Fields of Interest: 

Dr. Perry graduated from medical school at Georgetown University in Washington, DC. He completed an internship in internal medicine and residency in neurology at the Mayo Clinic in Rochester, Minnesota where he also researched obsessive-compulsive features in dementia. He is an Assistant Professor of Neurology at the Memory and Aging Center and participates in the evaluation and treatment of patients in the MAC clinic.

His current area of research interest is the impact of neurodegenerative illness on reward processing.

Publications: 

Diminished baseline autonomic outflow in semantic dementia relates to left-lateralized insula atrophy.

NeuroImage. Clinical

Hua AY, Roy ARK, Kosik EL, Morris NA, Chow TE, Lukic S, Montembeault M, Borghesani V, Younes K, Kramer JH, Seeley WW, Perry DC, Miller ZA, Rosen HJ, Miller BL, Rankin KP, Gorno-Tempini ML, Sturm VE

Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome.

Alzheimer's research & therapy

Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL, Gardner RC, Wang KKW, Kramer JH, Rabinovici GD

Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia.

Human brain mapping

Sokolowski A, Roy ARK, Goh SM, Hardy EG, Datta S, Cobigo Y, Brown JA, Spina S, Grinberg L, Kramer J, Rankin KP, Seeley WW, Sturm VE, Rosen HJ, Miller BL, Perry DC

Behavioural subphenotypes and their anatomic correlates in neurodegenerative disease.

Brain Communications

Roy ARK, Datta S, Hardy E, Sturm VE, Kramer JH, Seeley WW, Rankin KP, Rosen HJ, Miller BL, Perry DC

Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease.

Brain : a journal of neurology

Tanner JA, Iaccarino L, Edwards L, Asken BM, Gorno-Tempini ML, Kramer JH, Pham J, Perry DC, Possin K, Malpetti M, Mellinger T, Miller BL, Miller Z, Mundada NS, Rosen HJ, Soleimani-Meigooni DN, Strom A, La Joie R, Rabinovici GD

Right temporal lobe and socioemotional semantics: semantic behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Younes K, Borghesani V, Montembeault M, Spina S, Mandelli ML, Welch AE, Weis E, Callahan P, Elahi FM, Hua AY, Perry DC, Karydas A, Geschwind D, Huang E, Grinberg LT, Kramer JH, Boxer AL, Rabinovici GD, Rosen HJ, Seeley WW, Miller ZA, Miller BL, Sturm VE, Rankin KP, Luisa Gorno-Tempini M

A systematic review of digital technology to evaluate motor function and disease progression in motor neuron disease.

Journal of neurology

Beswick E, Fawcett T, Hassan Z, Forbes D, Dakin R, Newton J, Abrahams S, Carson A, Chandran S, Perry D, Pal S

Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateralized atrophy in the temporal and frontal lobes.

Cortex; a journal devoted to the study of the nervous system and behavior

Shdo SM, Roy ARK, Datta S, Sible IJ, Lukic S, Perry DC, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW, Holley SR, Gorno-Tempini ML, Sturm VE

Multimodal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinico-Pathological Case Series.

Journal of neurotrauma

Asken B, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, Perry DC, Miller BL, Spina S, Seeley WW, Kramer J, Grinberg LT, Rabinovici G

Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.

JAMA network open

Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, Gorno-Tempini ML, Rosen HJ, Grinberg LT, Spina S, La Joie R, Rabinovici GD, Miller BL, Rojas JC, Seeley WW, Boxer AL

Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases.

Journal of Alzheimer's disease : JAD

de Paula França Resende E, Ketelle R, Karydas A, Allen I, Grinberg LT, Spina S, Seeley WW, Perry DC, Miller B, Naasan G

Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration.

JAMA network open

Illán-Gala I, Falgàs N, Friedberg A, Castro-Suárez S, Keret O, Rogers N, Oz D, Nigro S, Quattrone A, Quattrone A, Wolf A, Younes K, Santos-Santos M, Borrego-Écija S, Cobigo Y, Dols-Icardo O, Lladó A, Sánchez-Valle R, Clarimon J, Blesa R, Alcolea D, Fortea J, Lleó A, Grinberg LT, Spina S, Kramer JH, Rabinovici GD, Boxer A, Gorno Tempini ML, Miller BL, Seeley WW, Rosen HJ, Perry DC

Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Illán-Gala I, Casaletto KB, Borrego-Écija S, Arenaza-Urquijo EM, Wolf A, Cobigo Y, Goh SYM, Staffaroni AM, Alcolea D, Fortea J, Blesa R, Clarimon J, Iulita MF, Brugulat-Serrat A, Lladó A, Grinberg LT, Possin K, Rankin KP, Kramer JH, Rabinovici GD, Boxer A, Seeley WW, Sturm VE, Gorno-Tempini ML, Miller BL, Sánchez-Valle R, Perry DC, Lleó A, Rosen HJ

Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET.

Neurology

La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Plasma tau and neurofilament light in frontotemporal lobar degeneration and Alzheimer's disease.

Neurology

Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer J, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley W, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC

Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.

American journal of speech-language pathology

Europa E, Iaccarino L, Perry DC, Weis E, Welch AE, Rabinovici GD, Miller BL, Gorno-Tempini ML, Henry ML

Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.

Brain : a journal of neurology

Ducharme S, Dols A, Laforce R, Devenney E, Kumfor F, van den Stock J, Dallaire-Théroux C, Seelaar H, Gossink F, Vijverberg E, Huey E, Vandenbulcke M, Masellis M, Trieu C, Onyike C, Caramelli P, de Souza LC, Santillo A, Waldö ML, Landin-Romero R, Piguet O, Kelso W, Eratne D, Velakoulis D, Ikeda M, Perry D, Pressman P, Boeve B, Vandenberghe R, Mendez M, Azuar C, Levy R, Le Ber I, Baez S, Lerner A, Ellajosyula R, Pasquier F, Galimberti D, Scarpini E, van Swieten J, Hornberger M, Rosen H, Hodges J, Diehl-Schmid J, Pijnenburg Y

Profiles of neurobehavior and their associations with brain abnormalities on MRI in infants born preterm.

Early human development

Kennedy E, Wouldes T, Perry D, Deib G, Alsweiler J, Crowther C, Harding J, MagNUM Study Group

Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.

Science translational medicine

La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, Tsai RM, Miller BL, Jagust WJ, Rabinovici GD

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

NeuroImage. Clinical

Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.

Alzheimer disease and associated disorders

Takeda A, Sturm VE, Rankin KP, Ketelle R, Miller BL, Perry DC

Factors that predict diagnostic stability in neurodegenerative dementia.

Journal of neurology

Perry DC, Datta S, Miller ZA, Rankin KP, Gorno-Tempini ML, Kramer JH, Rosen HJ, Seeley WW, Miller BL

Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

NeuroImage. Clinical

Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW

18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Alzheimer's research & therapy

Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD

Resting parasympathetic dysfunction predicts prosocial helping deficits in behavioral variant frontotemporal dementia.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Sible IJ, Datta S, Hua AY, Perry DC, Kramer JH, Miller BL, Seeley WW, Rosen HJ

Enhanced Positive Emotional Reactivity Undermines Empathy in Behavioral Variant Frontotemporal Dementia.

Frontiers in neurology

Hua AY, Sible IJ, Perry DC, Rankin KP, Kramer JH, Miller BL, Rosen HJ, Sturm VE

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Neurology

Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski JQ, Miller BL, Seeley WW

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

The New England journal of medicine

Rangarajan S, Walsh L, Lester W, Perry D, Madan B, Laffan M, Yu H, Vettermann C, Pierce GF, Wong WY, Pasi KJ

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli.

Brain : a journal of neurology

Perry DC, Datta S, Sturm VE, Wood KA, Zakrzewski J, Seeley WW, Miller BL, Kramer JH, Rosen HJ

Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy.

Brain and behavior

Sturm VE, Perry DC, Wood K, Hua AY, Alcantar O, Datta S, Rankin KP, Rosen HJ, Miller BL, Kramer JH

Precipitous Deterioration of Motor Function, Cognition, and Behavior.

JAMA neurology

Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD

Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Proceedings of the National Academy of Sciences of the United States of America

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV, Gan L

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Neurology

Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD

Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke.

Stroke

Mair G, von Kummer R, Adami A, White PM, Adams ME, Yan B, Demchuk AM, Farrall AJ, Sellar RJ, Sakka E, Palmer J, Perry D, Lindley RI, Sandercock PA, Wardlaw JM, IST-3 Collaborative Group

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.

JAMA neurology

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.

Journal of neurosurgery

Perry DC, Sturm VE, Peterson MJ, Pieper CF, Bullock T, Boeve BF, Miller BL, Guskiewicz KM, Berger MS, Kramer JH, Welsh-Bohmer KA

The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.

Brain : a journal of neurology

Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD

Amyloid in dementia associated with familial FTLD: not an innocent bystander.

Neurocase

Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ

Divergent processing of monetary and social reward in behavioral variant frontotemporal dementia and Alzheimer disease.

Alzheimer disease and associated disorders

Perry DC, Sturm VE, Wood KA, Miller BL, Kramer JH

Criminal behavior in frontotemporal dementia and Alzheimer disease.

JAMA neurology

Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL

High volume image-guided Injections for patellar tendinopathy: a combined retrospective and prospective case series.

Muscles, ligaments and tendons journal

Morton S, Chan O, King J, Perry D, Crisp T, Maffulli N, Morrissey D

Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Sturm VE, Seeley WW, Miller BL, Kramer JH, Rosen HJ

Frontotemporal dementia.

Seminars in neurology

Perry DC, Miller BL

[��5I]AT-1012, a new high affinity radioligand for the a3�4 nicotinic acetylcholine receptors.

Neuropharmacology

Wu J, Perry DC, Bupp JE, Jiang F, Polgar WE, Toll L, Zaveri NT

Eligibility for randomized trials of treatments specifically for intracerebral hemorrhage: community-based study.

Stroke

Fonville AF, Samarasekera N, Hutchison A, Perry D, Roos YB, Al-Shahi Salman R

A randomized clinical trial of trans-dermal nicotine replacement in pregnant African-American smokers.

Maternal and child health journal

El-Mohandes AA, Windsor R, Tan S, Perry DC, Gantz MG, Kiely M

Progranulin mutations as risk factors for Alzheimer disease.

JAMA neurology

Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G

Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.

Neurology

Lamarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Sha SJ, Perry DC, Miller ZA, Naasan G, Laforce R, Hagen J, Takada LT, Tartaglia MC, Kang G, Galasko D, Salmon DP, Farias ST, Kaur B, Olichney JM, Quitania Park L, Mendez MF, Tsai PH, Teng E, Dickerson BC, Domoto-Reilly K, McGinnis S, Miller BL, Kramer JH

Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

The Journal of pharmacology and experimental therapeutics

Hussmann GP, Turner JR, Lomazzo E, Venkatesh R, Cousins V, Xiao Y, Yasuda RP, Wolfe BB, Perry DC, Rezvani AH, Levin ED, Blendy JA, Kellar KJ

Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia.

European journal of neurology

Perry DC, Whitwell JL, Boeve BF, Pankratz VS, Knopman DS, Petersen RC, Jack CR, Josephs KA

Relationships between self-reported smoking, household environmental tobacco smoke exposure and depressive symptoms in a pregnant minority population.

Maternal and child health journal

Tan S, Courtney LP, El-Mohandes AA, Gantz MG, Blake SM, Thornberry J, El-Khorazaty MN, Perry D, Kiely M

Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.

The Journal of physiology

Othman NA, Gallacher M, Deeb TZ, Baptista-Hon DT, Perry DC, Hales TG

Thorough work-up and new diagnostic criteria needed for CJD.

Nature reviews. Neurology

Perry DC, Geschwind MD

Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.

Journal of neurochemistry

Lomazzo E, Hussmann GP, Wolfe BB, Yasuda RP, Perry DC, Kellar KJ

Dipstick tests for secondhand smoke exposure.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Best D, Green EM, Smith JH, Perry DC

Development of an undergraduate pharmacogenomics curriculum.

Pharmacogenomics

O'Brien TJ, Goodsaid F, Plack M, Harralson A, Harrouk W, Hales TG, Mandel HG, Perry DC, Kennedy K, Sarvazyan N, Chiappinelli VA

Evaluation of the immediate impact of the Washington, D.C., smoke-free indoor air policy on bar employee environmental tobacco smoke exposure.

Public health reports (Washington, D.C. : 1974)

Pearson J, Windsor R, El-Mohandes A, Perry DC

Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism.

Neurotoxicity research

Rasmussen BA, Perry DC, O'Neil J, Manaye KF, Tizabi Y

Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain.

The Journal of pharmacology and experimental therapeutics

Perry DC, Mao D, Gold AB, McIntosh JM, Pezzullo JC, Kellar KJ

Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats.

Psychopharmacology

Rasmussen BA, O'Neil J, Manaye KF, Perry DC, Tizabi Y

Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning.

The Journal of rheumatology

Perry D, Stewart N, Benton N, Robinson E, Yeoman S, Crabbe J, McQueen F

Beliefs, death, anxiety, denial, and treatment preferences in end-of-life care: a comparison of social work students, community residents, and medical students.

Journal of social work in end-of-life & palliative care

Reese DJ, Chan CL, Perry DC, Wiersgalla D, Schlinger JM

Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.

Journal of neurochemistry

Perry DC, Xiao Y, Nguyen HN, Musachio JL, Dávila-García MI, Kellar KJ