Howie Rosen, MD

Professor
Neurology
+1 415 476-5567

Dr. Rosen is a behavioral neurologist. He received his medical degree from Boston University School of Medicine, trained in internal medicine at the Albert Einstein College of Medicine in New York, and subsequently completed a neurology residency at UCSF. After residency, Dr. Rosen pursued fellowship training in brain imaging at the Washington University School of Medicine, and then returned to UCSF to join the team at the Memory and Aging Center (MAC) in 1999.

Dr. Rosen’s primary research interest is in the effects that atypical neurodegenerative diseases, in particular frontotemporal dementia, have on the brain, especially the emotional systems. His current projects use psychophysiology and imaging to examine how these diseases affect self-awareness, and to determine how imaging and other biological markers can be used to track and to anticipate how these disease affect the brain over time. He is also director of education and outreach for the education core in UCSF’s Alzheimer’s Disease Research Center.

As part of the MAC and the UCSF Department of Neurology, he participates in the training of medical students, residents and fellows, and participates in the evaluation of new patients in the MAC clinic as well as the continued management of care for some of these individuals in the continuity clinic.

Publications: 

Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration.

JAMA neurology

Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, Gorno-Tempini ML

Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Block NR, Sha SJ, Karydas AM, Fong JC, De May MG, Miller BL, Rosen HJ

Anomalous functional language lateralization in semantic variant PPA.

Neurology

Miller ZA, Hinkley LB, Herman A, Honma S, Findlay A, Block N, Ketelle R, Rabinovici G, Rosen H, Nagarajan SS, Miller BL, Gorno-Tempini ML

Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Yokoyama JS, Eckart JA, Zakrzewski J, Rosen HJ, Miller BL, Seeley WW, Levenson RW

Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion.

Brain : a journal of neurology

Lee SE, Khazenzon AM, Trujillo AJ, Guo CC, Yokoyama JS, Sha SJ, Takada LT, Karydas AM, Block NR, Coppola G, Pribadi M, Geschwind DH, Rademakers R, Fong JC, Weiner MW, Boxer AL, Kramer JH, Rosen HJ, Miller BL, Seeley WW

The Chinese Verbal Learning Test specifically assesses hippocampal state.

American journal of Alzheimer's disease and other dementias

Tsai RM, Leong JK, Dutt S, Chang CC, Lee AK, Chao SZ, Yokoyama JS, Tse M, Kramer JH, Miller BL, Rosen HJ

Self-awareness in neurodegenerative disease relies on neural structures mediating reward-driven attention.

Brain : a journal of neurology

Shany-Ur T, Lin N, Rosen HJ, Sollberger M, Miller BL, Rankin KP

Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Sturm VE, Seeley WW, Miller BL, Kramer JH, Rosen HJ

Application of quantitative DTI metrics in sporadic CJD.

NeuroImage. Clinical

Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD

Depressive symptoms in Chinese-American subjects with cognitive impairment.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Chao SZ, Matthews BR, Yokoyama JS, Lai NB, Ong H, Tse M, Yuan RF, Lin A, Kramer J, Yaffe K, Kornak J, Miller BL, Rosen HJ

MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements.

PloS one

Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW

Progranulin mutations as risk factors for Alzheimer disease.

JAMA neurology

Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G

TDP-43 frontotemporal lobar degeneration and autoimmune disease.

Journal of neurology, neurosurgery, and psychiatry

Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, Kramer JH, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Wyss-Coray T, Miller BL

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease.

Brain : a journal of neurology

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes.

Journal of Alzheimer's disease : JAD

Zhang Y, Tartaglia MC, Schuff N, Chiang GC, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL

The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementia.

Journal of the International Neuropsychological Society : JINS

Possin KL, Chester SK, Laluz V, Bostrom A, Rosen HJ, Miller BL, Kramer JH

Role of right pregenual anterior cingulate cortex in self-conscious emotional reactivity.

Social cognitive and affective neuroscience

Sturm VE, Sollberger M, Seeley WW, Rankin KP, Ascher EA, Rosen HJ, Miller BL, Levenson RW

Trajectories of behavioral disturbance in dementia.

Journal of Alzheimer's disease : JAD

Chow TW, Fridhandler JD, Binns MA, Lee A, Merrilees J, Rosen HJ, Ketelle R, Miller BL

Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis.

Brain : a journal of neurology

Olney NT, Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ

Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.

Neurology

Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ

Neuroimaging in dementia.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Tartaglia MC, Rosen HJ, Miller BL

Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden.

Brain : a journal of neurology

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O'Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ

Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease.

Alzheimer disease and associated disorders

Krueger CE, Dean DL, Rosen HJ, Halabi C, Weiner M, Miller BL, Kramer JH

Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease.

NeuroImage

Rosen HJ, Alcantar O, Rothlind J, Sturm V, Kramer JH, Weiner M, Miller BL

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI.

Brain : a journal of neurology

Zhang Y, Schuff N, Du AT, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW

Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease.

Journal of the International Neuropsychological Society : JINS

Possin KL, Brambati SM, Rosen HJ, Johnson JK, Pa J, Weiner MW, Miller BL, Kramer JH

Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia.

Human brain mapping

Young K, Du AT, Kramer J, Rosen H, Miller B, Weiner M, Schuff N

Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease.

Alzheimer disease and associated disorders

Geschwind MD, Potter CA, Sattavat M, Garcia PA, Rosen HJ, Miller BL, DeArmond SJ

Neuroimaging in dementia.

Seminars in neurology

Vitali P, Migliaccio R, Agosta F, Rosen HJ, Geschwind MD

Dextromethorphan/quinidine sulfate for pseudobulbar affect.

Drugs of today (Barcelona, Spain : 1998)

Rosen H

Cortical neuroanatomy and cognition.

Handbook of clinical neurology

Rosen HJ, Viskontas IV

Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration.

American journal of Alzheimer's disease and other dementias

Rabinovici GD, Seeley WW, Kim EJ, Gorno-Tempini ML, Rascovsky K, Pagliaro TA, Allison SC, Halabi C, Kramer JH, Johnson JK, Weiner MW, Forman MS, Trojanowski JQ, Dearmond SJ, Miller BL, Rosen HJ

Patterns of white matter atrophy in frontotemporal lobar degeneration.

Archives of neurology

Chao LL, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW

Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study.

Neurobiology of aging

Brambati SM, Rankin KP, Narvid J, Seeley WW, Dean D, Rosen HJ, Miller BL, Ashburner J, Gorno-Tempini ML

Magnetic resonance imaging correlates of set shifting.

Journal of the International Neuropsychological Society : JINS

Kramer JH, Quitania L, Dean D, Neuhaus J, Rosen HJ, Halabi C, Weiner MW, Magnotta VA, Delis DC, Miller BL

11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.

Neurology

Rabinovici GD, Furst AJ, O'Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.

Brain : a journal of neurology

Du AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, Weiner MW

A tensor based morphometry study of longitudinal gray matter contraction in FTD.

NeuroImage

Brambati SM, Renda NC, Rankin KP, Rosen HJ, Seeley WW, Ashburner J, Weiner MW, Miller BL, Gorno-Tempini ML

A real reason for patients with pseudobulbar affect to smile.

Annals of neurology

Rosen HJ, Cummings J

Behavioral features in semantic dementia vs other forms of progressive aphasias.

Neurology

Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, Miller BL, Gorno-Tempini ML

Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI.

Neurology

Du AT, Jahng GH, Hayasaka S, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin KP, Miller BL, Weiner MW, Schuff N

Multiple cognitive deficits in amnestic mild cognitive impairment.

Dementia and geriatric cognitive disorders

Kramer JH, Nelson A, Johnson JK, Yaffe K, Glenn S, Rosen HJ, Miller BL

Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy.

Archives of neurology

Boxer AL, Geschwind MD, Belfor N, Gorno-Tempini ML, Schauer GF, Miller BL, Weiner MW, Rosen HJ

Clinical and neuropsychological features of corticobasal degeneration.

Mechanisms of ageing and development

Belfor N, Amici S, Boxer AL, Kramer JH, Gorno-Tempini ML, Rosen HJ, Miller BL

Dissociations in hippocampal and frontal contributions to episodic memory performance.

Neuropsychology

Kramer JH, Rosen HJ, Du AT, Schuff N, Hollnagel C, Weiner MW, Miller BL, Delis DC

Neuroanatomical correlates of behavioural disorders in dementia.

Brain : a journal of neurology

Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL

Neuroanatomical correlates of impaired recognition of emotion in dementia.

Neuropsychologia

Rosen HJ, Wilson MR, Schauer GF, Allison S, Gorno-Tempini ML, Pace-Savitsky C, Kramer JH, Levenson RW, Weiner M, Miller BL

Frontotemporal lobar degeneration: demographic characteristics of 353 patients.

Archives of neurology

Johnson JK, Diehl J, Mendez MF, Neuhaus J, Shapira JS, Forman M, Chute DJ, Roberson ED, Pace-Savitsky C, Neumann M, Chow TW, Rosen HJ, Forstl H, Kurz A, Miller BL

The natural history of temporal variant frontotemporal dementia.

Neurology

Seeley WW, Bauer AM, Miller BL, Gorno-Tempini ML, Kramer JH, Weiner M, Rosen HJ

Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.

The Journal of clinical investigation

Goetzl EJ, Rosen H

Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia.

Alzheimer disease and associated disorders

Rosen HJ, Narvaez JM, Hallam B, Kramer JH, Wyss-Coray C, Gearhart R, Johnson JK, Miller BL

Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration.

Cortex; a journal devoted to the study of the nervous system and behavior

Gorno-Tempini ML, Rankin KP, Woolley JD, Rosen HJ, Phengrasamy L, Miller BL

Hippocampal volume and retention in Alzheimer's disease.

Journal of the International Neuropsychological Society : JINS

Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, Miller BL, Weiner MW, Chui HC

Cognition and anatomy in three variants of primary progressive aphasia.

Annals of neurology

Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL

Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD.

Dementia and geriatric cognitive disorders

Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL

Recognition of emotion in the frontal and temporal variants of frontotemporal dementia.

Dementia and geriatric cognitive disorders

Rosen HJ, Pace-Savitsky K, Perry RJ, Kramer JH, Miller BL, Levenson RW

Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment.

Neurology

Boxer AL, Kramer JH, Du AT, Schuff N, Weiner MW, Miller BL, Rosen HJ

Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, Miller BL

Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia.

Archives of neurology

Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ

Emotion comprehension in the temporal variant of frontotemporal dementia.

Brain : a journal of neurology

Rosen HJ, Perry RJ, Murphy J, Kramer JH, Mychack P, Schuff N, Weiner M, Levenson RW, Miller BL

Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD.

Neurology

Rosen HJ, Hartikainen KM, Jagust W, Kramer JH, Reed BR, Cummings JL, Boone K, Ellis W, Miller C, Miller BL

Patterns of brain atrophy in frontotemporal dementia and semantic dementia.

Neurology

Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, Feiwell R, Kramer JH, Miller BL

Patterns of cerebral atrophy in primary progressive aphasia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL

Neuroanatomy of the self: evidence from patients with frontotemporal dementia.

Neurology

Miller BL, Seeley WW, Mychack P, Rosen HJ, Mena I, Boone K