Katherine Possin, PhD

Associate Professor
Neurology
+1 415 476-1889

Dr. Possin is an Associate Professor of Neuropsychology at the Memory and Aging Center within the UCSF Department of Neurology. Dr. Possin’s research examines the neural bases of visual spatial and executive function impairments in neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, and frontotemporal lobar degeneration. She develops cognitive assessment tools to support neurodegenerative disease diagnosis and monitoring, including virtual reality tests of navigation and tablet-based tools for clinical applications. Dr. Possin is the Principal Investigator of a Healthcare Innovations Award to develop and test the Care Ecosystem study, a continuous and personalized model of dementia care supported by innovative technologies. Her research is also funded by grants from the Global Brain Health Institute and the Administration for Community Living.

Kate Possin was awarded her PhD degree in clinical psychology from UCSD in 2007. During her training at UCSD, she studied cognitive changes associated with Parkinson’s disease. She completed her internship in clinical neuropsychology at UCSF in the Departments of Psychiatry and Neurology and her postdoctoral fellowship in the Department of Neurology.

Publications: 

Extended, continuous measures of functional status in community dwelling persons with Alzheimer's and related dementia: Infrastructure, performance, tradeoffs, preliminary data, and promise.

Journal of neuroscience methods

Zylstra B, Netscher G, Jacquemot J, Schaffer M, Shen G, Bowhay AD, Braley TL, Possin KL, Miller BL, Bayen AM, Schenk AK, Bonasera SJ

Distinct Physical Function Profiles in Older Adults Receiving Cancer Chemotherapy.

Journal of pain and symptom management

Miaskowski C, Wong ML, Cooper BA, Mastick J, Paul SM, Possin K, Steinman M, Cataldo J, Dunn LB, Ritchie C

Egocentric and Allocentric Visuospatial Working Memory in Premotor Huntington's Disease: a Double Dissociation with Caudate and Hippocampal Volumes.

Neuropsychologia

Possin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH

Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem.

PLoS medicine

Possin KL, Merrilees J, Bonasera SJ, Bernstein A, Chiong W, Lee K, Wilson L, Hooper SM, Dulaney S, Braley T, Laohavanich S, Feuer JE, Clark AM, Schaffer MW, Schenk AK, Heunis J, Ong P, Cook KM, Bowhay AD, Gearhart R, Chodos A, Naasan G, Bindman AB, Dohan D, Ritchie C, Miller BL

Surface-based morphometry reveals caudate subnuclear structural damage in patients with premotor Huntington disease.

Brain imaging and behavior

Kim H, Kim JH, Possin KL, Winer J, Geschwind MD, Xu D, Hess CP

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.

JAMA neurology

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Cross-species translation of the Morris maze for Alzheimer's disease.

The Journal of clinical investigation

Possin KL, Sanchez PE, Anderson-Bergman C, Fernandez R, Kerchner GA, Johnson ET, Davis A, Lo I, Bott NT, Kiely T, Fenesy MC, Miller BL, Kramer JH, Finkbeiner S

Lewy body dementias.

Lancet (London, England)

Walker Z, Possin KL, Boeve BF, Aarsland D

Which figure copy test is more sensitive for cognitive impairment in Parkinson's disease: Wire cube or interlocking pentagons?

Clinical neurology and neurosurgery

Alty JE, Cosgrove J, Jamieson S, Smith SL, Possin KL

Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series.

Neurology. Clinical practice

Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD

Cavum Septum Pellucidum in Retired American Pro-Football Players.

Journal of neurotrauma

Gardner RC, Hess CP, Brus-Ramer M, Possin KL, Cohn-Sheehy BI, Kramer JH, Berger MS, Yaffe K, Miller B, Rabinovici GD

Executive dysfunction.

Continuum (Minneapolis, Minn.)

Rabinovici GD, Stephens ML, Possin KL

Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Migliaccio R, Agosta F, Possin KL, Canu E, Filippi M, Rabinovici GD, Rosen HJ, Miller BL, Gorno-Tempini ML

Sensitive measures of executive dysfunction in non-demented Parkinson's disease.

Parkinsonism & related disorders

Bott NT, Johnson ET, Schuff N, Galifianakis N, Subas T, Pollock J, Pressman P, Kramer JH, Possin KL

Quantitative 7T phase imaging in premanifest Huntington disease.

AJNR. American journal of neuroradiology

Apple AC, Possin KL, Satris G, Johnson E, Lupo JM, Jakary A, Wong K, Kelley DA, Kang GA, Sha SJ, Kramer JH, Geschwind MD, Nelson SJ, Hess CP

Executive functions in premanifest Huntington's disease.

Movement disorders : official journal of the Movement Disorder Society

You SC, Geschwind MD, Sha SJ, Apple A, Satris G, Wood KA, Johnson ET, Gooblar J, Feuerstein JS, Finkbeiner S, Kang GA, Miller BL, Hess CP, Kramer JH, Possin KL

Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.

Neurology

Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL

Executive function in children with attention deficit/hyperactivity disorder: the NIH EXAMINER battery.

Journal of the International Neuropsychological Society : JINS

Schreiber JE, Possin KL, Girard JM, Rey-Casserly C

NIH EXAMINER: conceptualization and development of an executive function battery.

Journal of the International Neuropsychological Society : JINS

Kramer JH, Mungas D, Possin KL, Rankin KP, Boxer AL, Rosen HJ, Bostrom A, Sinha L, Berhel A, Widmeyer M

Rivastigmine is associated with restoration of left frontal brain activity in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society

Possin KL, Kang GA, Guo C, Fine EM, Trujillo AJ, Racine CA, Wilheim R, Johnson ET, Witt JL, Seeley WW, Miller BL, Kramer JH

Ecological validity and neuroanatomical correlates of the NIH EXAMINER executive composite score.

Journal of the International Neuropsychological Society : JINS

Possin KL, LaMarre AK, Wood KA, Mungas DM, Kramer JH

Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias.

Neurology

Possin KL, Feigenbaum D, Rankin KP, Smith GE, Boxer AL, Wood K, Hanna SM, Miller BL, Kramer JH

White matter atrophy in Alzheimer's disease variants.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Migliaccio R, Agosta F, Possin KL, Rabinovici GD, Miller BL, Gorno-Tempini ML

The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementia.

Journal of the International Neuropsychological Society : JINS

Possin KL, Chester SK, Laluz V, Bostrom A, Rosen HJ, Miller BL, Kramer JH

Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging.

Movement disorders : official journal of the Movement Disorder Society

Zhan W, Kang GA, Glass GA, Zhang Y, Shirley C, Millin R, Possin KL, Nezamzadeh M, Weiner MW, Marks WJ, Schuff N

Assessment of cognition in early dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Silverberg NB, Ryan LM, Carrillo MC, Sperling R, Petersen RC, Posner HB, Snyder PJ, Hilsabeck R, Gallagher M, Raber J, Rizzo A, Possin K, King J, Kaye J, Ott BR, Albert MS, Wagster MV, Schinka JA, Cullum CM, Farias ST, Balota D, Rao S, Loewenstein D, Budson AE, Brandt J, Manly JJ, Barnes L, Strutt A, Gollan TH, Ganguli M, Babcock D, Litvan I, Kramer JH, Ferman TJ

Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults.

Journal of the International Neuropsychological Society : JINS

Pa J, Possin KL, Wilson SM, Quitania LC, Kramer JH, Boxer AL, Weiner MW, Johnson JK

Parkinsonian dementias.

Continuum (Minneapolis, Minn.)

Possin KL, Kaufer DI

Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative disease.

Neuropsychologia

Luks TL, Oliveira M, Possin KL, Bird A, Miller BL, Weiner MW, Kramer JH

Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease.

Journal of the International Neuropsychological Society : JINS

Possin KL, Brambati SM, Rosen HJ, Johnson JK, Pa J, Weiner MW, Miller BL, Kramer JH

Space-based but not object-based inhibition of return is impaired in Parkinson's disease.

Neuropsychologia

Possin KL, Filoteo JV, Song DD, Salmon DP

Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia.

Proceedings of the National Academy of Sciences of the United States of America

Agosta F, Vossel KA, Miller BL, Migliaccio R, Bonasera SJ, Filippi M, Boxer AL, Karydas A, Possin KL, Gorno-Tempini ML

The early neuropsychological and behavioral characteristics of frontotemporal dementia.

Neuropsychology review

Wittenberg D, Possin KL, Rascovsky K, Rankin KP, Miller BL, Kramer JH

Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior.

Annals of the New York Academy of Sciences

Viskontas IV, Possin KL, Miller BL

Lack of impairment in patients with Parkinson's disease on an object-based negative priming task.

Perceptual and motor skills

Possin KL, Cagigas XE, Strayer DL, Filoteo JV

The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Zizak VS, Filoteo JV, Possin KL, Lucas JA, Rilling LM, Davis JD, Peavy G, Wong A, Salmon DP

Is a perseveration a perseveration? An evaluation of cognitive error types in patients with subcortical pathology.

Journal of clinical and experimental neuropsychology

Possin KL, Filoteo JV, Roesch SC, Zizak V, Rilling LM, Davis JD

Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: a preliminary proton MRS study. Magnetic resonance spectroscopy.

Psychiatry research

Nordahl TE, Salo R, Possin K, Gibson DR, Flynn N, Leamon M, Galloway GP, Pfefferbaum A, Spielman DM, Adalsteinsson E, Sullivan EV

Preliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals.

Psychiatry research

Salo R, Nordahl TE, Possin K, Leamon M, Gibson DR, Galloway GP, Flynn NM, Henik A, Pfefferbaum A, Sullivan EV

The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

Neurology

Silverberg GD, Heit G, Huhn S, Jaffe RA, Chang SD, Bronte-Stewart H, Rubenstein E, Possin K, Saul TA