Victor Valcour, MD, PhD

Professor of Neurology
Neurology
+1 415 476-3746

Dr. Valcour is a Professor of Medicine with a shared appointment in the Division of Geriatric Medicine and the Department of Neurology.  His work crosses disciplines to research and care for cognitive disorders in aging populations and to understand brain injury in the setting of HIV among all ages, including funded pediatric HIV studies.  His clinical work involves consultations for patients with cognitive disorders at the UCSF Memory and Aging Center.  

While much of Dr. Valcour's research is completed at UCSF, he has a large internationa porfolio with many opportunities for junior investigators.  Within Southeast Asia, he is Deputy Director of SEARCH/Thailand operating research in acute HIV (within days of infection), pediatric HIV, and markers of dementia in chronic HIV.  In Africa, he has partnered with the US Military HIV Research Program to survey cognitive disorders among HIV-infected individuals in Nigeria, Uganda, Kenya, and Tanzania.  

Dr. Valcour is broadly involved in mentoring individuals at all levels of training who are interested in clinical research related to cognitive disorders, particularly in association with HIV infection.  He has extensive global health experience.

Dr. Valcour’s research interests have two major emphases.  He is currently developing a research program that aims to understand optimal care strategies for elders who develop dementia.  Nested within the Memory and Aging Center, the long-term goal of this program is to provide model care for elders with cognitive disorders.

Dr. Valcour is internationally recognized for research in cognitive disorders related to HIV. He currently operates 3 NIH R01 series grants within 3 novel cohorts: (1) a chronic HIV infected cohort followed since first initiation of cART; (2) an acute HIV cohort of individuals infected for less than one month at enrollment; (3) and a pediatric cohort in Thailand and Cambodia.  He is the Deputy Director of SEARCH/Thailand (www.SEARCHThailand.org).  He also operates the UCSF HIV Over 60 Cohort focused on understanding cognitive disorders in the older HIV population living in the San Francisco Bay area.  New research will survey of cognitive disorders in HIV for individuals living in Uganda, Kenya, Tanzania and Nigeria.

Dr. Valcour is actively engaged in mentoring individuals wishing to become independent clinical researchers.  His research portfolio provides a broad array of local and international projects that can serve as resources for mentored projects. Dr. Valcour serves as an Executive Committee member of the AIDS Research Institute (ARI).

Publications: 

Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression.

Neurology

Rubin LH, Maki PM, Springer G, Benning L, Anastos K, Gustafson D, Villacres MC, Jiang X, Adimora AA, Waldrop-Valverde D, Vance DE, Bolivar H, Alden C, Martin EM, Valcour VG

Perceived and post-traumatic stress are associated with decreased learning, memory, and fluency in HIV-infected women.

AIDS (London, England)

Rubin LH, Cook JA, Springer G, Weber KM, Cohen MH, Martin EM, Valcour VG, Benning L, Alden C, Milam J, Anastos K, Young MA, Gustafson DR, Sundermann EE, Maki PM

Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation.

AIDS and behavior

Hellmuth J, Colby D, Valcour V, Suttichom D, Spudich S, Ananworanich J, Prueksakaew P, Sailasuta N, Allen I, Jagodzinski LL, Slike B, Ochi D, Paul R

High Number of Activated CD8+ T Cells Targeting HIV Antigens are Present in Cerebrospinal Fluid in Acute HIV Infection.

Journal of acquired immune deficiency syndromes (1999)

Kessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Nichols C, Josey BJ, Slike B, Krebs SJ, Sailsuta N, Lerdlum S, Jagodzinski L, Tipsuk S, Suttichom D, Rattanamanee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb ML, Michael NL, Ananworanich J, Trautmann L

Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders.

Journal of acquired immune deficiency syndromes (1999)

Agsalda-Garcia MA, Sithinamsuwan P, Valcour VG, Chalermchai T, Tipsuk S, Kuroda J, Nakamura C, Ananworanich J, Zhang G, Schuetz A, Slike BM, Shiramizu B

Psychiatric symptom burden in older people living with HIV with and without cognitive impairment: the UCSF HIV over 60 cohort study.

AIDS care

Milanini B, Catella S, Perkovich B, Esmaeili-Firidouni P, Wendelken L, Paul R, Greene M, Ketelle R, Valcour V

White matter hyperintensities correlate to cognition and fiber tract integrity in older adults with HIV.

Journal of neurovirology

Watson C, Busovaca E, Foley JM, Allen IE, Schwarz CG, Jahanshad N, Nir TM, Esmaeili-Firidouni P, Milanini B, Rosen H, Carmichael OT, Thompson PM, Valcour VG

Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection.

AIDS (London, England)

Peluso MJ, Valcour V, Phanuphak N, Ananworanich J, Fletcsher JL, Chalermchai T, Krebs SJ, Robb ML, Hellmuth J, Gisslén M, Zetterberg H, Spudich S

ApoE e4 is Associated with Cognition, Brain Integrity and Atrophy in HIV Over Age 60.

Journal of acquired immune deficiency syndromes (1999)

Wendelken LA, Jahanshad N, Rosen HJ, Busovaca E, Allen I, Coppola G, Adams C, Rankin KP, Milanini B, Clifford K, Wojta K, Nir TM, Gutman BA, Thompson PM, Valcour V

Neurologic signs and symptoms frequently manifest in acute HIV infection.

Neurology

Kamtchum-Tatuene J, Wan Sulaiman WA, Lekoubou A, Hellmuth J, Valcour V, Spudich S

Monocyte Activation is Associated with Worse Cognitive Performance in Virologically Suppressed HIV-Infected Women.

The Journal of infectious diseases

Imp BM, Rubin LH, Tien PC, Plankey MW, Golub ET, French AL, Valcour VG

Initiation of antiretroviral therapy in early HIV infection reduces but does not abrogate chronic residual inflammation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Sereti I, Krebs SJ, Phanuphak N, Fletcher JL, Slike B, Pinyakorn S, O'Connell RJ, Rupert A, Chomont N, Valcour V, Kim JH, Robb ML, Michael NL, Douek DC, Ananworanich J, Utay NS

Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment.

Scientific reports

Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK

Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification.

Human brain mapping

Zhang Y, Kwon D, Esmaeili-Firidouni P, Pfefferbaum A, Sullivan EV, Javitz H, Valcour V, Pohl KM

Cognitive Impairment and Persistent CNS Injury in Treated HIV.

Current HIV/AIDS reports

Chan P, Hellmuth J, Spudich S, Valcour V

Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection.

PLoS pathogens

Muir R, Metcalf T, Tardif V, Takata H, Phanuphak N, Kroon E, Colby DJ, Trichavaroj R, Valcour V, Robb ML, Michael NL, Ananworanich J, Trautmann L, Haddad EK

Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C.

Journal of acquired immune deficiency syndromes (1999)

Valcour VG, Rubin LH, Obasi MU, Maki PM, Peters MG, Levin S, Crystal HA, Young MA, Mack WJ, Cohen MH, Pierce CB, Adimora AA, Tien PC

Sex differences in soluble markers vary before and after the initiation of antiretroviral therapy in chronically HIV-infected individuals.

AIDS (London, England)

Krebs SJ, Slike BM, Sithinamsuwan P, Allen IE, Chalermchai T, Tipsuk S, Phanuphak N, Jagodzinski L, Kim JH, Ananworanich J, Marovich MA, Valcour VG

Neurologic signs and symptoms frequently manifest in acute HIV infection.

Neurology

Hellmuth J, Fletcher JL, Valcour V, Kroon E, Ananworanich J, Intasan J, Lerdlum S, Narvid J, Pothisri M, Allen I, Krebs SJ, Slike B, Prueksakaew P, Jagodzinski LL, Puttamaswin S, Phanuphak N, Spudich S

Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection.

Journal of Virus Eradication

Ananworanich J, Sacdalan CP, Pinyakorn S, Chomont N, de Souza M, Luekasemsuk T, Schuetz A, Krebs SJ, Dewar R, Jagodzinski L, Ubolyam S, Trichavaroj R, Tovanabutra S, Spudich S, Valcour V, Sereti I, Michael N, Robb M, Phanuphak P, Kim JH, Phanuphak N

Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy.

Journal of acquired immune deficiency syndromes (1999)

Sailasuta N, Ananworanich J, Lerdlum S, Sithinamsuwan P, Fletcher JL, Tipsuk S, Pothisri M, Jadwattanakul T, Jirajariyavej S, Chalermchai T, Catella S, Busovaca E, Desai A, Paul R, Valcour V

Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy.

Journal of acquired immune deficiency syndromes (1999)

Kore I, Ananworanich J, Valcour V, Fletcher JL, Chalermchai T, Paul R, Reynolds J, Tipsuk S, Ubolyam S, Rattanamanee S, Jagodzinski L, Kim J, Spudich S

Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.

PloS one

Valcour VG, Spudich SS, Sailasuta N, Phanuphak N, Lerdlum S, Fletcher JL, Kroon ED, Jagodzinski LL, Allen IE, Adams CL, Prueksakaew P, Slike BM, Hellmuth JM, Kim JH, Ananworanich J

Mapping abnormal subcortical brain morphometry in an elderly HIV + cohort.

NeuroImage. Clinical

Wade BS, Valcour VG, Wendelken-Riegelhaupt L, Esmaeili-Firidouni P, Joshi SH, Gutman BA, Thompson PM

Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women.

Journal of neurovirology

Rubin LH, Pyra M, Cook JA, Weber KM, Cohen MH, Martin E, Valcour V, Milam J, Anastos K, Young MA, Alden C, Gustafson DR, Maki PM

Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born to HIV-infected Mothers.

The Pediatric infectious disease journal

Jahanshad N, Couture MC, Prasitsuebsai W, Nir TM, Aurpibul L, Thompson PM, Pruksakaew K, Lerdlum S, Visrutaratna P, Catella S, Desai A, Kerr SJ, Puthanakit T, Paul R, Ananworanich J, Valcour VG

Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60.

Journal of neurovirology

Guha A, Wang L, Tanenbaum A, Esmaeili-Firidouni P, Wendelken LA, Busovaca E, Clifford K, Desai A, Ances BM, Valcour V

Geriatric Syndromes in Older HIV-Infected Adults.

Journal of acquired immune deficiency syndromes (1999)

Greene M, Covinsky KE, Valcour V, Miao Y, Madamba J, Lampiris H, Cenzer IS, Martin J, Deeks SG

Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection.

The Journal of infectious diseases

Peluso MJ, Valcour V, Ananworanich J, Sithinamsuwan P, Chalermchai T, Fletcher JL, Lerdlum S, Chomchey N, Slike B, Sailasuta N, Gisslén M, Zetterberg H, Spudich S

CNS reservoirs for HIV: implications for eradication.

Journal of Virus Eradication

Hellmuth J, Valcour V, Spudich S

MAPPING ABNORMAL SUBCORTICAL BRAIN MORPHOMETRY IN AN ELDERLY HIV+ COHORT.

Proceedings. IEEE International Symposium on Biomedical Imaging

Wade BS, Valcour VG, Wendelken-Riegelhaupt L, Esmaeili-Firidouni P, Joshi SH, Wang Y, Thompson PM

The association of perceived stress and verbal memory is greater in HIV-infected versus HIV-uninfected women.

Journal of neurovirology

Rubin LH, Cook JA, Weber KM, Cohen MH, Martin E, Valcour V, Milam J, Anastos K, Young MA, Alden C, Gustafson DR, Maki PM

Subcortical shape and volume abnormalities in an elderly HIV+ cohort.

Proceedings of SPIE--the International Society for Optical Engineering

Wade BS, Valcour V, Busovaca E, Esmaeili-Firidouni P, Joshi SH, Wang Y, Thompson PM

Association between brain volumes and HAND in cART-naïve HIV+ individuals from Thailand.

Journal of neurovirology

Heaps JM, Sithinamsuwan P, Paul R, Lerdlum S, Pothisri M, Clifford D, Tipsuk S, Catella S, Busovaca E, Fletcher JL, Raudabaugh B, Ratto-Kim S, Valcour V, Ananworanich J

Acute tubular nephropathy in a patient with acute HIV infection: review of the literature.

AIDS research and therapy

Ananworanich J, Datta AA, Fletcher JL, Townamchai N, Chomchey N, Kroon E, Sereti I, Valcour V, Kim JH

Interactions between ageing and NeuroAIDS.

Current opinion in HIV and AIDS

Hellmuth J, Milanini B, Valcour V

Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease.

Journal of neurovirology

Paul RH, Joska JA, Woods C, Seedat S, Engelbrecht S, Hoare J, Heaps J, Valcour V, Ances B, Baker LM, Salminen LE, Stein DJ

The Montreal cognitive assessment to screen for cognitive impairment in HIV patients older than 60 years.

Journal of acquired immune deficiency syndromes (1999)

Milanini B, Wendelken LA, Esmaeili-Firidouni P, Chartier M, Crouch PC, Valcour V

HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy.

AIDS (London, England)

Kallianpur KJ, Valcour VG, Lerdlum S, Busovaca E, Agsalda M, Sithinamsuwan P, Chalermchai T, Fletcher JL, Tipsuk S, Shikuma CM, Shiramizu BT, Ananworanich J

Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV.

AIDS care

Kerr SJ, Puthanakit T, Vibol U, Aurpibul L, Vonthanak S, Kosalaraksa P, Kanjanavanit S, Hansudewechakul R, Wongsawat J, Luesomboon W, Ratanadilok K, Prasitsuebsai W, Pruksakaew K, van der Lugt J, Paul R, Ananworanich J, Valcour V

Practice effect and normative data of an HIV-specific neuropsychological testing battery among healthy Thais.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet

Sithinamsuwan P, Hutchings N, Ananworanich J, Wendelken L, Saengtawan P, Paul R, Chomchey N, Fletcher JL, Chalermchai T, Valcour V

Anthropometric measures and cognition in middle-aged HIV-infected and uninfected women. The Women's Interagency HIV Study.

Journal of neurovirology

Gustafson DR, Mielke MM, Tien PC, Valcour V, Cohen M, Anastos K, Liu C, Pearce L, Golub ET, Minkoff H, Crystal HA

HIV DNA reservoir increases risk for cognitive disorders in cART-naïve patients.

PloS one

Valcour VG, Ananworanich J, Agsalda M, Sailasuta N, Chalermchai T, Schuetz A, Shikuma C, Liang CY, Jirajariyavej S, Sithinamsuwan P, Tipsuk S, Clifford DB, Paul R, Fletcher JL, Marovich MA, Slike BM, DeGruttola V, Shiramizu B

Ethnic differences in epidermal nerve fiber density.

Muscle & nerve

Shikuma CM, McArthur JC, Ebenezer GJ, Ananworanich J, Teeratakulpisarn N, Jadwattanakul T, Valcour VG, Bennett K, Phanuphak N

HIV, aging, and cognition: emerging issues.

Topics in antiviral medicine

Valcour VG

Dementia in the oldest old: a multi-factorial and growing public health issue.

Alzheimer's research & therapy

Gardner RC, Valcour V, Yaffe K

HIV and recent illicit drug use interact to affect verbal memory in women.

Journal of acquired immune deficiency syndromes (1999)

Meyer VJ, Rubin LH, Martin E, Weber KM, Cohen MH, Golub ET, Valcour V, Young MA, Crystal H, Anastos K, Aouizerat BE, Milam J, Maki PM

Cognitive function and neurodevelopmental outcomes in HIV-infected Children older than 1 year of age randomized to early versus deferred antiretroviral therapy: the PREDICT neurodevelopmental study.

The Pediatric infectious disease journal

Puthanakit T, Ananworanich J, Vonthanak S, Kosalaraksa P, Hansudewechakul R, van der Lugt J, Kerr SJ, Kanjanavanit S, Ngampiyaskul C, Wongsawat J, Luesomboon W, Vibol U, Pruksakaew K, Suwarnlerk T, Apornpong T, Ratanadilok K, Paul R, Mofenson LM, Fox L, Valcour V, Brouwers P, Ruxrungtham K

Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter.

Neurology

Kallianpur KJ, Shikuma C, Kirk GR, Shiramizu B, Valcour V, Chow D, Souza S, Nakamoto B, Sailasuta N

Management of human immunodeficiency virus infection in advanced age.

JAMA

Greene M, Justice AC, Lampiris HW, Valcour V

Deficits in self-awareness impact the diagnosis of asymptomatic neurocognitive impairment in HIV.

AIDS research and human retroviruses

Chiao S, Rosen HJ, Nicolas K, Wendelken LA, Alcantar O, Rankin KP, Miller B, Valcour V

Trail Making Test A improves performance characteristics of the International HIV Dementia Scale to identify symptomatic HAND.

Journal of neurovirology

Chalermchai T, Valcour V, Sithinamsuwan P, Pinyakorn S, Clifford D, Paul RH, Tipsuk S, Fletcher JL, Degruttola V, Ratto-Kim S, Hutchings N, Shikuma C, Ananworanich J

Mapping white matter integrity in elderly people with HIV.

Human brain mapping

Nir TM, Jahanshad N, Busovaca E, Wendelken L, Nicolas K, Thompson PM, Valcour VG

A 72-week randomized study of the safety and efficacy of a stavudine to zidovudine switch at 24 weeks compared to zidovudine or tenofovir disoproxil fumarate when given with lamivudine and nevirapine.

Antiviral therapy

Phanuphak N, Ananworanich J, Teeratakulpisarn N, Jadwattanakul T, Kerr SJ, Chomchey N, Hongchookiat P, Mathajittiphun P, Pinyakorn S, Rungrojrat P, Praihirunyakit P, Gerschenson M, Phanuphak P, Valcour V, Kim JH, Shikuma C

Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection.

PloS one

Sailasuta N, Ross W, Ananworanich J, Chalermchai T, DeGruttola V, Lerdlum S, Pothisri M, Busovaca E, Ratto-Kim S, Jagodzinski L, Spudich S, Michael N, Kim JH, Valcour V

Development of normative neuropsychological performance in Thailand for the assessment of HIV-associated neurocognitive disorders.

Journal of clinical and experimental neuropsychology

Heaps J, Valcour V, Chalermchai T, Paul R, Rattanamanee S, Siangphoe U, Sithinamsuwan P, Chairangsaris P, Nidhinandana S, Tipsuk S, Suttichom D, Fletcher J, Shikuma C, Ananworanich J

Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.

Antiviral therapy

Shikuma CM, Nakamoto B, Shiramizu B, Liang CY, DeGruttola V, Bennett K, Paul R, Kallianpur K, Chow D, Gavegnano C, Hurwitz SJ, Schinazi RF, Valcour VG

Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy.

Journal of neurovirology

Bunupuradah T, Chetchotisakd P, Jirajariyavej S, Valcour V, Bowonwattanuwong C, Munsakul W, Klinbuayaem V, Prasithsirikul W, Sophonphan J, Mahanontharit A, Hirschel B, Bhakeecheep S, Ruxrungtham K, Ananworanich J

HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group.

Journal of acquired immune deficiency syndromes (1999)

High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, Deren S, Effros RB, Gebo K, Goronzy JJ, Justice AC, Landay A, Levin J, Miotti PG, Munk RJ, Nass H, Rinaldo CR, Shlipak MG, Tracy R, Valcour V, Vance DE, Walston JD, Volberding P

Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals.

Journal of neurovirology

Nakamoto BK, Jahanshad N, McMurtray A, Kallianpur KJ, Chow DC, Valcour VG, Paul RH, Marotz L, Thompson PM, Shikuma CM

Central nervous system viral invasion and inflammation during acute HIV infection.

The Journal of infectious diseases

Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D, Suwanwela NC, Jagodzinski L, Michael N, Spudich S, van Griensven F, de Souza M, Kim J, Ananworanich J

Impact of HIV and aging on neuropsychological function.

Journal of neurovirology

Wendelken LA, Valcour V

Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

PloS one

Ananworanich J, Schuetz A, Vandergeeten C, Sereti I, de Souza M, Rerknimitr R, Dewar R, Marovich M, van Griensven F, Sekaly R, Pinyakorn S, Phanuphak N, Trichavaroj R, Rutvisuttinunt W, Chomchey N, Paris R, Peel S, Valcour V, Maldarelli F, Chomont N, Michael N, Phanuphak P, Kim JH

Effects of hepatitis C and HIV on cognition in women: data from the Women's Interagency HIV Study.

Journal of acquired immune deficiency syndromes (1999)

Crystal H, Kleyman I, Anastos K, Lazar J, Cohen M, Liu C, Pearce L, Golub E, Valcour V, Ho A, Strickler H, Peters M, Kovacs A, Holman S, Kreek MJ, Manly J

Cognitive performance related to HIV-1-infected monocytes.

The Journal of neuropsychiatry and clinical neurosciences

Kusao I, Shiramizu B, Liang CY, Grove J, Agsalda M, Troelstrup D, Velasco VN, Marshall A, Whitenack N, Shikuma C, Valcour V

Disrupted brain networks in the aging HIV+ population.

Brain connectivity

Jahanshad N, Valcour VG, Nir TM, Kohannim O, Busovaca E, Nicolas K, Thompson PM

Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy.

Journal of neurovirology

Shiramizu B, Ananworanich J, Chalermchai T, Siangphoe U, Troelstrup D, Shikuma C, De Grutolla V, Sithinamsuwan P, Praihirunkit P, Rattanamanee S, Valcour V

The Impact of Depressive Symptoms on Neuropsychological Performance Tests in HIV-Infected Individuals: A Study of the Hawaii Aging with HIV Cohort.

World journal of AIDS

Shimizu SM, Chow DC, Valcour V, Masaki K, Nakamoto B, Kallianpur KJ, Shikuma C

Regional cortical thinning associated with detectable levels of HIV DNA.

Cerebral cortex (New York, N.Y. : 1991)

Kallianpur KJ, Kirk GR, Sailasuta N, Valcour V, Shiramizu B, Nakamoto BK, Shikuma C

Insulin resistance and cognition among HIV-infected and HIV-uninfected adult women: the Women's Interagency HIV Study.

AIDS research and human retroviruses

Valcour V, Maki P, Bacchetti P, Anastos K, Crystal H, Young M, Mack WJ, Cohen M, Golub ET, Tien PC

Associations of cardiovascular variables and HAART with cognition in middle-aged HIV-infected and uninfected women.

Journal of neurovirology

Crystal HA, Weedon J, Holman S, Manly J, Valcour V, Cohen M, Anastos K, Liu C, Mack WJ, Golub E, Lazar J, Ho A, Kreek MJ, Kaplan RC

Screening for cognitive impairment in human immunodeficiency virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Valcour V, Paul R, Chiao S, Wendelken LA, Miller B

Impact of cerebrovascular disease on cognitive function in HIV-infected patients.

Journal of acquired immune deficiency syndromes (1999)

Nakamoto BK, Valcour VG, Kallianpur K, Liang CY, McMurtray A, Chow D, Kappenburg E, Shikuma CM

Preventing dementia: is there hope for progress?

American family physician

Perissinotto CM, Valcour V

Pathogenesis of HIV in the central nervous system.

Current HIV/AIDS reports

Valcour V, Sithinamsuwan P, Letendre S, Ances B

The Effects of Age and HIV on Neuropsychological Performance.

Journal of the International Neuropsychological Society : JINS

Valcour V, Paul R, Neuhaus J, Shikuma C

A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women.

Addiction biology

Crystal HA, Hamon S, Randesi M, Cook J, Anastos K, Lazar J, Liu C, Pearce L, Golub E, Valcour V, Weber KM, Holman S, Ho A, Kreek MJ

Incident neuropathy in HIV-infected patients on HAART.

AIDS research and human retroviruses

Nakamoto BK, McMurtray A, Davis J, Valcour V, Watters MR, Shiramizu B, Chow DC, Kallianpur K, Shikuma CM

HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications.

Journal of leukocyte biology

Valcour VG, Shiramizu BT, Shikuma CM

Neurocognitive impairment and psychiatric comorbidity in well-controlled human immunodeficiency virus-infected Thais from the 2NN Cohort Study.

Journal of neurovirology

Pumpradit W, Ananworanich J, Lolak S, Shikuma C, Paul R, Siangphoe U, Chaoniti N, Kaew-On P, Paris R, Ruxrungtham K, Valcour V

Aging with HIV. Lessons from CROI 2009.

Positively aware : the monthly journal of the Test Positive Aware Network

Valcour V

HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study.

Neurology

Valcour VG, Shiramizu BT, Sithinamsuwan P, Nidhinandana S, Ratto-Kim S, Ananworanich J, Siangphoe U, Kim JH, de Souza M, Degruttola V, Paul RH, Shikuma CM

Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection.

HIV medicine

Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Millar L, Gould M, Tran P, Shikuma C, Souza S, McArthur JC

Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders.

The Journal of neuropsychiatry and clinical neurosciences

Shiramizu B, Williams AE, Shikuma C, Valcour V

Frequency and characteristics of HIV-associated sensory neuropathy among HIV patients in Bangkok, Thailand.

Journal of acquired immune deficiency syndromes (1999)

Sithinamsuwan P, Punthanamongkol S, Valcour V, Onsanit S, Nidhinandana S, Thitivichianlert S, Shikuma C

Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapy.

Journal of neurovirology

Valcour V, Watters MR, Williams AE, Sacktor N, McMurtray A, Shikuma C

Frequency of apolipoprotein E4 among older compared with younger HIV patients: support for detrimental effect of E4 on survival.

Proceedings of the National Academy of Sciences of the United States of America

Valcour V, Shiramizu B, Shikuma C

Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

McMurtray A, Nakamoto B, Shikuma C, Valcour V

A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia.

Nature clinical practice. Neurology

Valcour V, Haman A, Cornes S, Lawall C, Parsa AT, Glaser C, Yagi S, Tihan T, Bhatnagar J, Geschwind M

Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand.

Journal of neuroimmunology

Ratto-Kim S, Chuenchitra T, Pulliam L, Paris R, Sukwit S, Gongwon S, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Shiramizu BT, de Souza MS, Chitpatima ST, Sun B, Rempel H, Nitayaphan S, Williams K, Kim JH, Shikuma CM, Valcour VG

Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090.

HIV clinical trials

Evans SR, Yeh TM, Sacktor N, Clifford DB, Simpson D, Miller EN, Ellis RJ, Valcour V, Marra CM, Millar L, Schifitto G

Updated research nosology for HIV-associated neurocognitive disorders.

Neurology

Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE

A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment.

Neurology

Schifitto G, Zhang J, Evans SR, Sacktor N, Simpson D, Millar LL, Hung VL, Miller EN, Smith E, Ellis RJ, Valcour V, Singer E, Marra CM, Kolson D, Weihe J, Remmel R, Katzenstein D, Clifford DB

Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort study.

Cerebrovascular diseases (Basel, Switzerland)

McMurtray A, Nakamoto B, Shikuma C, Valcour V

Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy.

Neurology

Zhou L, Kitch DW, Evans SR, Hauer P, Raman S, Ebenezer GJ, Gerschenson M, Marra CM, Valcour V, Diaz-Arrastia R, Goodkin K, Millar L, Shriver S, Asmuth DM, Clifford DB, Simpson DM, McArthur JC

Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals.

Journal of neurovirology

Sacktor N, Skolasky R, Selnes OA, Watters M, Poff P, Shiramizu B, Shikuma C, Valcour V

Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection.

Neurology

Valcour VG, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Ratto-Kim S, Apateerapong W, Shiramizu BT, Desouza MS, Chitpatima ST, Watt G, Chuenchitra T, Robertson KR, Paul RH, McArthur JC, Kim JH, Shikuma CM

HIV proviral DNA associated with decreased neuropsychological function.

The Journal of neuropsychiatry and clinical neurosciences

Shiramizu B, Paul R, Williams A, Shikuma C, Watters M, Grove J, Valcour V

HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand.

International journal of medical sciences

Shiramizu B, Ratto-Kim S, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Watt G, deSouza M, Chuenchitra T, Sukwit S, Chitpatima S, Robertson K, Paul R, Shikuma C, Valcour V

Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort.

Journal of acquired immune deficiency syndromes (1999)

Valcour VG, Sacktor NC, Paul RH, Watters MR, Selnes OA, Shiramizu BT, Williams AE, Shikuma CM

HIV infection and dementia in older adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Valcour V, Paul R

Distinct mechanisms of T cell reconstitution can be identified by estimating thymic volume in adult HIV-1 disease.

The Journal of infectious diseases

Kalayjian RC, Spritzler J, Pu M, Landay A, Pollard RB, Stocker V, Harthi LA, Gross BH, Francis IR, Fiscus SA, Tebas P, Bosch RJ, Valcour V, Lederman MM

Discordant plasma and cerebral spinal fluid cytokines/chemokines in relation to HIV-1-associated dementia.

Cellular and molecular biology (Noisy-le-Grand, France)

Killebrew DA, Troelstrup D, Valcour V, Williams A, Aguon J, Sapalo D, Shikuma C, Ratto-Kim S, Shiramizu B

HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Shikuma CM, Valcour VG, Ratto-Kim S, Williams AE, Souza S, Gerschenson M, Day L, Kim JH, Shiramizu B

Circulating proviral HIV DNA and HIV-associated dementia.

AIDS (London, England)

Shiramizu B, Gartner S, Williams A, Shikuma C, Ratto-Kim S, Watters M, Aguon J, Valcour V

Diabetes, insulin resistance, and dementia among HIV-1-infected patients.

Journal of acquired immune deficiency syndromes (1999)

Valcour VG, Shikuma CM, Shiramizu BT, Williams AE, Watters MR, Poff PW, Grove JS, Selnes OA, Sacktor NC

Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort.

Journal of neuroimmunology

Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes OA, Grove J, Liu Y, Abdul-Majid KB, Gartner S, Sacktor N

Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort.

Neurology

Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N

Symptomatic distal sensory polyneuropathy in HIV after age 50.

Neurology

Watters MR, Poff PW, Shiramizu BT, Holck PS, Fast KM, Shikuma CM, Valcour VG

Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms.

AIDS (London, England)

Valcour VG, Shikuma CM, Watters MR, Sacktor NC

Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reaction.

Frontiers in bioscience : a journal and virtual library

Shiramizu B, Gartner S, Cho M, Liu Y, Pyron N, Valcour V, Shikuma C

Tetanus immunity in long-term care facilities.

Journal of the American Geriatrics Society

Fernandes R, Valcour V, Flynn B, Masaki K, Blanchette P

Self-reported driving, cognitive status, and physician awareness of cognitive impairment.

Journal of the American Geriatrics Society

Valcour VG, Masaki KH, Blanchette PL

The detection of dementia in the primary care setting.

Archives of internal medicine

Valcour VG, Masaki KH, Curb JD, Blanchette PL

Spontaneous ecchymoses due to paroxetine administration.

The American journal of medicine

Cooper TA, Valcour VG, Gibbons RB, O'Brien-Falls K