Normal Aging and Cognitive Decline

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Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program. Joining this program involves a single visit every 15 months and will enable you to get involved in other related research projects, like this study, if you’re interested.


  • Study director: Joel Kramer, PsyD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: Mechanisms of Executive Decline in Normal Aging
  • Conditions studied: Healthy aging
  • Purpose: This is a longitudinal study which aims at identifying the cognitive mechanisms and neural structures that underlie the decline in executive functioning observed in normal aging.


  • Inclusion criteria: Volunteers between the ages 40–100 with minor or no memory problems involved in the Healthy Aging study
  • Exclusion criteria: Significant memory problems, diagnosis of a neurodegenerative disease, major psychiatric disorder, abuse of drugs/alcohol, or metal in body/pacemaker

What is involved?

  • Testing: Computer-based tests measuring attention and reaction time, paper and pencil cognitive testing, and brain MRI
  • Frequency of visits: 1 visit every 30 months longitudinally (3 hours of testing and 1 hour MRI scan)
  • Materials needed prior to evaluation: None
  • Costs: No costs will be charged for any of the study procedures. Parking will be validated for the 1625 Owens Street Garage or 1630 Third Street Garage at the UCSF Mission Bay campus for all study visits. There is no monetary compensation for participation.

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