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The LAVA Clinical Research Management System (CRMS) was developed by the UCSF Memory and Aging Center (MAC) to meet the data management needs of a research center with a dynamic and varied set of patient assessment measures and many interrelated research protocols. The system includes a query tool, LAVA Query, which allows principal investigators to create specialized cohorts and generate their own data sets. The system is web-based and can host data for multisite studies. LAVA is used by several national NIH-funded Alzheimer's Disease Research Centers (ADRCs) and includes all forms for the full Uniform Data Set (UDS) maintained by the National Alzheimer’s Coordinating Center (NACC). Programmers at the ADRC sites collaborate in an open source manner to maintain and enhance the LAVA code base. The LAVA framework can also be used to build CRMS systems for other disciplines. LAVA database applications have been created for UCSF investigators within multiple sclerosis and surgical movement disorders. UCSF MAC makes the LAVA source code freely available. The LAVA source code is freely available under an open-source license in the "lava" GitHub repository. Additionally a LAVA demo application is in the "lava-uds" repository. Please contact Charlie Toohey for more information about LAVA.

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Investigators who would like to use UCSF MAC resources need to submit a completed proposal (abstract, purpose, background and preliminary findings, methods, analytical plan) to the UCSF MAC Resource Request Executive Committee for review. All MAC resource requests must include a completed UCSF MAC Data Use Agreement and be approved by the UCSF MAC Resource Request Executive Committee, which meets monthly to review all requests.

The UCSF Clinical and Translational Science Institute (CTSI) also maintains resources for investigators collaborating with UCSF.

April 1, 2014