Sleep and Cognition in Older Adults

Purpose of the Study

The purpose of this study is to determine how sleep is affected in both healthy aging and neurodegenerative processes. The study aims to determine whether sleep quality alters performance on cognitive tasks in older adults and whether this relationship changes with mild to moderate cognitive impairments.

Study Details

Inclusion Criteria

  • Participant must be in stable medical condition for one month prior to screening
  • All participants must be willing and able to undergo testing procedures

Exclusion Criteria

  • Major psychiatric disorder within the past two years
  • Neurological conditions affecting cognition (e.g., epilepsy)
  • Substance abuse or dependence
  • Significant systemic medical illnesses (e.g., cancer; renal failure, respiratory failure)
  • Current medication likely to affect central nervous system function
  • Insulin-dependent diabetes

What to Expect

Testing: If the screening exam shows that you are eligible and you choose to continue, you will be asked to participate in some or all of the following procedures during an 11-day at-home period: questionnaires, sleep journals, sleep/wake measurements, behavioral testing, movement measurements, and an overnight measurement of vitals. You may also be asked to participate in a ~24hr study at the UCSF Clinical Research Center to complete an overnight sleep assessment (polysomnography measurement) and daytime napping assessments.

The Frequency of Visits: The visit typically involves an initial screening at the UCSF Mission Bay campus for instructions on how to use the at-home measurement devices and some cognitive testing. In addition to completing the at-home portion of the study, you may be asked to stay one night and day in the Clinical Research Center at UCSF Parnassus campus. You may be asked to return for follow-up visits within 6–40 months of your original participation.

Materials Needed Before Evaluation: None

Costs: No costs will be charged for any of the study procedures. You may be eligible for travel reimbursements that involve participation in the study. There is no monetary compensation for participation.

Contact Information

If you are interested in participating in this study or have any questions, please contact the study director, Dr. Walsh, at Christine.Walsh@ucsf.edu.