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Related Literature

A selective review of the literature was completed prior to commencing study enrollment in 2006.

Introduction

The primary aim of this NINDS-initiated project is to develop a test battery that reliably and validly assesses executive function for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders.

Sites

The EXAMINER battery was administered at ten collaborating sites across the United States.

Ten nationwide sites completed the field tests:

  • The Memory and Aging Center at the University of California, San Francisco
    (PI: Joel Kramer, PsyD)
  • Boston Children’s Hospital Department of Neurology
    (PI: Celiane Rey-Casserly, PhD)
  • Case Western Reserve University Rainbow Hospital
    (PI: H. Gerry Taylor, PhD)
  • The Developmental Cognitive Neuroscience Laboratory at University of Nebraska-Lincoln
    (PI: Kimberly Espy, PhD)
  • The Mayo Clinic Alzheimer’s Disease Research Center
    (PI: Glenn Smith, PhD)

Subjects

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team.

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team. Piloting and ongoing data collection were conducted utilizing the large research infrastructure at UCSF and in collaboration with nine remote sites to represent a full range of geographic regions, ethnic groups, age groups, and diagnostic disorders.

Project Structure

EXAMINER was developed in two general phases. Phase I emphasized battery development and lasted two years. Phase II focused on data collection.

EXAMINER was developed in two general phases.

Phase One

Core Attributes of Battery

The overall goal of this five-year project was to develop a neuropsychological test battery to reliably and validly assess domains of executive function (often defined as the ability to engage in goal-oriented behavior) for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders.

The overall goal of this five-year project was to develop a neuropsychological test battery to reliably and validly assess domains of executive function (often defined as the ability to engage in goal-oriented behavior) for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders. Our battery of executive tests was modeled to encompass the attributes described below:

Background

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

Video

Health care educators can request video clips of behavior from the UCSF Memory and Aging Center (MAC) to use for professional education. These clips have been reviewed and characterized by the neurologists in our team, and the patients have consented to allow the clips to be used for educational purposes. Prior to submitting your request, please consult with the Clinical Core leader, Dr. Joel Kramer or Rosalie Gearhart at (415) 476-5570.

Subject Identity

Technology

The LAVA Clinical Research Management System (CRMS) was developed by the UCSF Memory and Aging Center (MAC) to meet the data management needs of a research center with a dynamic and varied set of patient assessment measures and many interrelated research protocols. The system includes a query tool, LAVA Query, which allows principal investigators to create specialized cohorts and generate their own data sets. The system is web-based and can host data for multisite studies.

Data Sharing

As an NIH-sponsored Alzheimer's Disease Research Center, the UCSF Memory and Aging Center (MAC) looks for opportunities to share our resources with investigators of the highest caliber. Investigators may request subjects for research studies from the UCSF MAC. Prior to submitting your application, please consult the Data Management & Biostatistics Core leader, Dr.

Biospecimens

As an NIH-sponsored Alzheimer's Disease Research Center, the UCSF Memory and Aging Center (MAC) welcomes opportunities to share our resources with investigators of the highest caliber. Investigators may request laboratory and biospecimens from the UCSF MAC. Prior to submitting your application, please consult the Clinical Core leader, Dr.

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