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The Neurodegenerative Disease Brain Bank (NDBB) was established in 2008 and serves as a repository for nervous system tissue donated for research purposes. The NDBB is committed to advancing the understanding of neurodegenerative disease by performing comprehensive neuropathological characterization of patients who participated in clinical research during life and by providing tissue to leading investigators worldwide.

The Neurodegenerative Disease Brain Bank (NDBB) was established in 2008 and serves as a repository for nervous system tissue donated for research purposes. The NDBB is committed to advancing the understanding of neurodegenerative disease by performing comprehensive neuropathological characterization of patients who participated in clinical research during life and by providing tissue to leading investigators worldwide.

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Contact us to learning more about the NIH EXAMINER project or gain access to assessment materials.

Interested in learning more about the EXAMINER project or gaining access to assessment materials?

Assessments

This page provides a descriptive overview of each EXAMINER measure by domain, along with a brief discussion of administration time.

Domains:


Domain: Working Memory

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Meeting Notes

The External Advisory Committee met regularly to review data and progress of the EXAMINER project.

External Advisory Committee meetings:

  • April 24, 2006
  • November 1, 2007
  • June 24, 2009
  • February 9, 2011

Related Literature

A selective review of the literature was completed prior to commencing study enrollment in 2006.

Introduction

The primary aim of this NINDS-initiated project is to develop a test battery that reliably and validly assesses executive function for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders.

Sites

The EXAMINER battery was administered at ten collaborating sites across the United States.

Ten nationwide sites completed the field tests:

  • The Memory and Aging Center at the University of California, San Francisco
    (PI: Joel Kramer, PsyD)
  • Boston Children’s Hospital Department of Neurology
    (PI: Celiane Rey-Casserly, PhD)
  • Case Western Reserve University Rainbow Hospital
    (PI: H. Gerry Taylor, PhD)
  • The Developmental Cognitive Neuroscience Laboratory at University of Nebraska-Lincoln
    (PI: Kimberly Espy, PhD)
  • The Mayo Clinic Alzheimer’s Disease Research Center
    (PI: Glenn Smith, PhD)

Subjects

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team.

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team. Piloting and ongoing data collection were conducted utilizing the large research infrastructure at UCSF and in collaboration with nine remote sites to represent a full range of geographic regions, ethnic groups, age groups, and diagnostic disorders.

Project Structure

EXAMINER was developed in two general phases. Phase I emphasized battery development and lasted two years. Phase II focused on data collection.

EXAMINER was developed in two general phases.

Phase One

Core Attributes of Battery

The overall goal of this five-year project was to develop a neuropsychological test battery to reliably and validly assess domains of executive function (often defined as the ability to engage in goal-oriented behavior) for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders.

The overall goal of this five-year project was to develop a neuropsychological test battery to reliably and validly assess domains of executive function (often defined as the ability to engage in goal-oriented behavior) for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders. Our battery of executive tests was modeled to encompass the attributes described below:

Background

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

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