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Request Tissue

Tissue is shared with investigators whose research is of superb scientific quality and occurs under the provision of a Material Transfer Agreement (MTA).

Tissue is shared with investigators whose research is of superb scientific quality and occurs under the provision of a Material Transfer Agreement (MTA). The MTA restricts the use of tissue to one study, prohibits the transfer of tissue to anyone outside the recipient organization without prior written approval of the NDBB, and requires the recipient organization to cite the contribution of the NDBB in any publications resulting from the use of the tissue. MTA request applications are reviewed by the UCSF Memory and Aging Center Resource Request Committee.

Brain Donation

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Why donate?

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Examining the brain after death is currently the only way to obtain a definitive diagnosis of the underlying causes of dementia. A diagnosis of absolute certainty cannot be made by clinical evaluation alone.

About Us

The Neurodegenerative Disease Brain Bank (NDBB) was established in 2008 and serves as a repository for nervous system tissue donated for research purposes. The NDBB is committed to advancing the understanding of neurodegenerative disease by performing comprehensive neuropathological characterization of patients who participated in clinical research during life and by providing tissue to leading investigators worldwide.

The Neurodegenerative Disease Brain Bank (NDBB) was established in 2008 and serves as a repository for nervous system tissue donated for research purposes. The NDBB is committed to advancing the understanding of neurodegenerative disease by performing comprehensive neuropathological characterization of patients who participated in clinical research during life and by providing tissue to leading investigators worldwide.

Neurodegenerative Disease Brain Bank Code of Ethics

Informed consent

Learn More

Contact us to learning more about the NIH EXAMINER project or gain access to assessment materials.

Interested in learning more about the EXAMINER project or gaining access to assessment materials?

Assessments

This page provides a descriptive overview of each EXAMINER measure by domain, along with a brief discussion of administration time.

Domains:


Domain: Working Memory

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Meeting Notes

The External Advisory Committee met regularly to review data and progress of the EXAMINER project.

External Advisory Committee meetings:

  • April 24, 2006
  • November 1, 2007
  • June 24, 2009
  • February 9, 2011

Related Literature

A selective review of the literature was completed prior to commencing study enrollment in 2006.

Introduction

The primary aim of this NINDS-initiated project is to develop a test battery that reliably and validly assesses executive function for clinical investigations and clinical trials that is adaptable across a wide range of ages and disorders.

Sites

The EXAMINER battery was administered at ten collaborating sites across the United States.

Ten nationwide sites completed the field tests:

  • The Memory and Aging Center at the University of California, San Francisco
    (PI: Joel Kramer, PsyD)
  • Boston Children’s Hospital Department of Neurology
    (PI: Celiane Rey-Casserly, PhD)
  • Case Western Reserve University Rainbow Hospital
    (PI: H. Gerry Taylor, PhD)
  • The Developmental Cognitive Neuroscience Laboratory at University of Nebraska-Lincoln
    (PI: Kimberly Espy, PhD)
  • The Mayo Clinic Alzheimer’s Disease Research Center
    (PI: Glenn Smith, PhD)

Subjects

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team.

A central goal of the EXAMINER project was to develop a battery that could reliably and validly assess executive functions across a wide range of ages and disorders. Data collection targets were established with this goal in mind by the EXAMINER advisory panel, NINDS focus groups, NINDS Project Officer, and the UCSF team. Piloting and ongoing data collection were conducted utilizing the large research infrastructure at UCSF and in collaboration with nine remote sites to represent a full range of geographic regions, ethnic groups, age groups, and diagnostic disorders.

Project Structure

EXAMINER was developed in two general phases. Phase I emphasized battery development and lasted two years. Phase II focused on data collection.

EXAMINER was developed in two general phases.

Phase One

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