research_studies

A listing of the open research studies at the MAC

IDEAS: Imaging Dementia – Evidence for Amyloid Scanning

The IDEAS study will investigate how a specific type of brain scan – known as an amyloid PET scan – helps guide doctors in treating mild cognitive impairment or dementia, and whether these changes in treatment lead to better medical outcomes for patients.

Summary

  • Study director: Gil Rabinovici, MD
  • Sponsor: Alzheimer’s Association
  • Recruiting?: Yes
  • Official study title: IDEAS: Imaging Dementia – Evidence for Amyloid Scanning

PET Imaging in Aging Population

The aim of this study is to identify the relationship between amyloid aggregation in the brain and brain structure and function. Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program.

Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program. Joining this program involves a single visit every 15 months and will enable you to get involved in other related research projects, like this study, if you’re interested.

Summary

4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

This is the second cycle of a study that aims to identify the best methods of analysis for tracking PSP and CBD over time.

Summary

  • Study director: Adam Boxer, MD PhD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: 4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

HIV Elder Study

The goal of this study is to determine the efficacy of mindfulness based stress reduction (MBSR) to alleviate stress, anxiety and depressive symptoms and improve attention among patients aged 60 or older who suffer from HIV-associated neurocognitive disorders (HAND) and have maximized treatment options.

Summary

Sleep and Cognition in Older Adults

The purpose of this study is to determine how sleep is affected in both healthy aging and neurodegenerative processes. The study aims to determine whether sleep quality alters performance on cognitive tasks in older adults and whether this relationship changes with mild to moderate cognitive impairments.

Summary

  • Study director: Christine Walsh, PhD
  • Sponsor: National Institute of Health (NIH) and the Tau Research Consortium
  • Recruiting?: Yes
  • Official study title: The Relationship Between Sleep and Cognition in Older Adults

Parkinson’s Disease Eligibility & Screening Visit

The Memory and Aging Center is currently recruiting participants with Parkinson’s disease (PD) for involvement in several different research projects at UC San Francisco and UC Berkeley.

Summary

  • Study director: Joel Kramer, PsyD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: Parkinson’s Disease Eligibility and Screening
  • Conditions studied: Parkinson's disease (PD)

Purpose of Study

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

The goal of this study is to support the development of FTLD therapies through a multi-site research consortium headquartered at UCSF. The study aims to determine the clinical, genetic, and biomarker profiles of FTLD syndromes where there is a strong correlation between clinical syndrome and underlying pathology (FTD-ALS, PSP, and semantic variant PPA (svPPA)). The study also aims to determine the natural history of familial FTLD using novel clinical measures.

Summary

  • Study directors: Adam Boxer, MD, PhD and Howard Rosen, MD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Familial Progressive Supranuclear Palsy (FamPSP)

The goal of this study is to identify rare genetic variants as risk factors for progressive supranuclear palsy (PSP). By studying patients with PSP and their relatives affected by related conditions, we hope to identify genes that are involved in PSP and related disorders.

Summary

Purpose of Study

Early Onset and Atypical Alzheimer’s Disease

Approximately 5% of patients with Alzheimer’s disease develop symptoms before age 65, without a known genetic cause. In this study, we use comprehensive clinical evaluations, cerebrospinal fluid (optional) and genetic analyses, and MRI and PET imaging to improve our understanding and diagnosis of early onset and atypical Alzheimer’s disease.

Summary

  • Study director: Gil Rabinovici, MD
  • Sponsor: National Institute on Aging
  • Official study title: Early Age-of-Onset AD: Clinical Heterogeneity and Network Degeneration
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