related_research

UCSF Over 80 Clinic

The staff of the UCSF Over 80 Clinic seek to address the complex dementia care issues commonly seen when caring for the oldest old. This care often requires an in-depth understanding of co-existing non-dementia medical illnesses, medication interactions, and the integrated living environment encountered in care of elders.

The staff of the UCSF Over 80 Clinic seek to address the complex dementia care issues commonly seen when caring for the oldest old. This care often requires an in-depth understanding of co-existing non-dementia medical illnesses, medication interactions, and the integrated living environment encountered in care of elders. In contrast to the clinical priorities for younger patients with cognitive decline, diagnosis is often only a small factor in maximizing outcomes.

Make a Referral

Thank you for considering a referral to the UCSF Memory and Aging Center. We appreciate the opportunity to provide consultation services to you and your patients. The clinical services at the Memory and Aging Center are focused on providing a diagnostic evaluation and treatment recommendations for neurodegenerative diseases. This includes diagnoses such as Alzheimer’s disease, vascular dementia and dementia with Lewy bodies as well as less common disorders such as frontotemporal dementia, Huntington’s disease and Creutzfeldt-Jakob disease. We also have a specialty clinic for patients with cognitive complaints that may be associated with movement disorders or genetic conditions. If you have questions about the process or would like to speak with someone about a referral, please call 415-353-2057.

Thank you for considering a referral to the UCSF Memory and Aging Center. We appreciate the opportunity to provide consultation services to you and your patients. The clinical services at the Memory and Aging Center are focused on providing a diagnostic evaluation and treatment recommendations for neurodegenerative diseases.

Brain Donation

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Why donate?

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Examining the brain after death is currently the only way to obtain a definitive diagnosis of the underlying causes of dementia. A diagnosis of absolute certainty cannot be made by clinical evaluation alone.

Background

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

Executive functioning is defined as the ability to engage in goal-oriented behavior. The relevance of executive functioning for problem solving, social behavior, successful adaptation, and carrying out of instrumental activities of daily living cannot be underestimated. Executive deficits can have a more devastating effect than poor memory on patients’ level of functioning.

Mild Alzheimer's Disease Trial with BMS-241027

BMS-241027, also known as Epothilone D, is a microtubule stabilizing agent that also has effects on tau protein in animal models of Alzheimer’s disease. The purpose of this study is to evaluate whether BMS-241027 is safe and well-tolerated in subjects with Alzheimer’s disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Bristol-Myers Squibb, Inc.
  • Recruiting?: Yes
  • Official study title: Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease
  • ClinicalTrials.gov identifier: NCT01492374

Prion Research as a Model

Submitted by admin on September 6, 2012 - 6:05pm
Content Link: 
http://www.youtube.com/watch?v=oCBfHHV1Dk8&feature=BFa&list=EC8FCF7487A6825F26
Content Type: 
video

Dr. Michael Geschwind and Dr. Stanley Prusiner share their work on prion disease as a model to hopefully find cures for not only Creutzfeldt-Jakob disease but also Alzheimer's disease, frontotemporal dementia and Parkinson's disease.

CJD & Other Prion Disorders

Submitted by admin on September 6, 2012 - 4:27pm
CJD & Other Prion Disorders
Content Link: 
http://www.youtube.com/watch?feature=player_embedded&v=yzDQ8WgFB_U
Content Type: 
video

This clip describes the origins of prion disease and what prions are.

Prion Resource Sharing

The Memory and Aging Center encourages and facilitates research and publications by current and new investigators. We are eager to help generate successful proposals, secure funding and publish study results. Resources are provided solely for use in academic, not-for-profit research at recognized educational institutions.

Academic, not-for-profit investigators can request the following resources from the UCSF Memory and Aging Center (MAC):

  • Subjects for research studies
  • Archived data
  • Imaging data
  • Tissue specimens
  • Video clips of behaviors

For details, please see our Resource Sharing page.

Prion Research Meetings

Scientific and medical meetings provide a forum for new ideas in research or treatment to be presented to colleagues and discussed. There are several meetings focused on prion disease.

Lorne Conference on Protein Structure and Function

  • February 10–14, 2013
  • Lorne, Victoria, Australia

This meeting is held each year in February at Lorne, a scenic beach resort 150 km from Melbourne and attracts approximately 450 protein scientists. The goal of the meeting is to highlight leading edge protein science, irrespective of its focus. The meeting includes oral and poster presentation sessions, a young investigator session, trade workshops, social events and trade displays.

Recent Publications About Prion Disease

To read scientific abstracts and articles, please search PubMed, a service of the National Library of Medicine and the National Institutes of Health or browse our selected list of articles about prion disease.

PubMed is a service of the National Library of Medicine and the National Institutes of Health. It comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Selected Articles Related to Prion Disease

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