related_research

PET Imaging in Aging Population

The aim of this study is to identify the relationship between amyloid aggregation in the brain and brain structure and function. Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program.

Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program. Joining this program involves a single visit every 15 months and will enable you to get involved in other related research projects, like this study, if you’re interested.

Summary

Alzheimer's Disease Trial with Crenezumab - Phase 3

The purpose of this study is to evaluate the efficacy and safety of crenezumab in patients with prodromal to mild Alzheimer’s disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: F. Hoffmann-La Roche Ltd.
  • Recruiting?: Yes
  • Official study title: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Crenezumab in Patients with Prodromal to Mild Alzheimer’s Disease

Progressive Supranuclear Palsy Trial of ABBV-8E12

The purpose of this study is to evaluate the efficacy and safety of ABBV-8E12 in patients with progressive supranuclear palsy.

Summary

  • Study director: Richard Tsai, MD
  • Sponsor: AbbVie
  • Recruiting?: Yes
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Progressive Supranuclear Palsy
  • ClinicalTrials.gov identifier: NCT02985879

4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

This is the second cycle of a study that aims to identify the best methods of analysis for tracking PSP and CBD over time.

Summary

  • Study director: Adam Boxer, MD PhD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: 4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

HIV Elder Study

The goal of this study is to determine the efficacy of mindfulness based stress reduction (MBSR) to alleviate stress, anxiety and depressive symptoms and improve attention among patients aged 60 or older who suffer from HIV-associated neurocognitive disorders (HAND) and have maximized treatment options.

Summary

Alzheimer’s Disease Trial with Aducanumab

The primary purpose of this study is to find out whether aducanumab has the potential to be a helpful treatment that slows down disease progression in subjects with early Alzheimer’s disease (AD) by comparing it to placebo and to evaluate its safety (side effects), and to find out more about aducanumab.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Biogen
  • Recruiting?: Yes
  • Official study title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease

Progressive Supranuclear Palsy Trial with C2N-8E12

The primary purpose of this study is to determine the safety, tolerability, and maximally tolerated dosage of C2N-8E12, and anti-tau monoclonal antibody. C2N-8E12 is an immunotherapy (antibody) drug designed to bind to and to remove tau protein. The tau protein is believed to build up to abnormally high levels in the brains of individuals with PSP. This abnormal accumulation is associated with clinical progression of the disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: C2N Diagnostics
  • Recruiting?: No
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects with Progressive Supranuclear Palsy

Progressive Supranuclear Palsy Trial with BMS-986168

The primary purpose of this study is to see how safe and well tolerated the study drug BMS-986168 is at different drug amounts in patients with PSP and to measure the amount of study drug in subject’s blood and cerebrospinal fluid (CSF) after taking the drug.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Bristol-Myers Squibb Company (BMS)
  • Recruiting?: No
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of Intravenously Administered BMS-986168 in Patients with Progressive Supranuclear Palsy (PSP)

Sleep and Cognition in Older Adults

The purpose of this study is to determine how sleep is affected in both healthy aging and neurodegenerative processes. The study aims to determine whether sleep quality alters performance on cognitive tasks in older adults and whether this relationship changes with mild to moderate cognitive impairments.

Summary

  • Study director: Christine Walsh, PhD
  • Sponsor: National Institute of Health (NIH) and the Tau Research Consortium
  • Recruiting?: Yes
  • Official study title: The Relationship Between Sleep and Cognition in Older Adults

Join a Supportive Care Trial

Quality of Life Trials or Supportive Care Trials are research studies to evaluate improving the health, care or quality of life for people, typically without using study drugs or devices. UCSF's Memory and Aging Center (MAC) runs selected supportive trials for people with neurodegenerative disease. Your participation helps us evaluate these interventions. If one of our trials looks interesting to you, please talk with your doctor or contact the study team to see if it is appropriate for you.

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