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PET Imaging in Aging Population

The aim of this study is to identify the relationship between amyloid aggregation in the brain and brain structure and function. Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program.

Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program. Joining this program involves a single visit every 15 months and will enable you to get involved in other related research projects, like this study, if you’re interested.

Summary

Alzheimer's Disease Trial with Crenezumab - Phase 3

The purpose of this study is to evaluate the efficacy and safety of crenezumab in patients with prodromal to mild Alzheimer’s disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: F. Hoffmann-La Roche Ltd.
  • Recruiting?: Yes
  • Official study title: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Crenezumab in Patients with Prodromal to Mild Alzheimer’s Disease

Progressive Supranuclear Palsy Trial of ABBV-8E12

The purpose of this study is to evaluate the efficacy and safety of ABBV-8E12 in patients with progressive supranuclear palsy.

Summary

  • Study director: Richard Tsai, MD
  • Sponsor: AbbVie
  • Recruiting?: Yes
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Progressive Supranuclear Palsy
  • ClinicalTrials.gov identifier: NCT02985879

4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

This is the second cycle of a study that aims to identify the best methods of analysis for tracking PSP and CBD over time.

Summary

  • Study director: Adam Boxer, MD PhD
  • Sponsor: National Institutes of Health (NIH)
  • Recruiting?: Yes
  • Official study title: 4 Repeat Tauopathy Neuroimaging Initiative – Cycle 2 (4RTNI-2)

Volunteer

The combination of clinical and research projects available at the UCSF Memory and Aging Center can provide meaningful experiences for volunteers.

Our vibrant combination of clinical and research projects can provide meaningful experiences for volunteers. As a volunteer, you will have the opportunity to work on a wide range of activities and programs while learning more about the neurological functioning of both healthy and ailing people. In addition, students have the opportunity to attend weekly seminars, grand rounds presentations, clinicopathological case conferences, and other research activities.

To Apply

HIV Elder Study

The goal of this study is to determine the efficacy of mindfulness based stress reduction (MBSR) to alleviate stress, anxiety and depressive symptoms and improve attention among patients aged 60 or older who suffer from HIV-associated neurocognitive disorders (HAND) and have maximized treatment options.

Summary

Family Advisory Council

To promote ideal family and patient-centered care in dementia, the UCSF Memory and Aging Center has created a Family Advisory Council that provides family caregiver input regarding the delivery of clinical care services.

To promote ideal family and patient-centered care in dementia, the UCSF Memory and Aging Center has created a Family Advisory Council that provides family caregiver input regarding the delivery of clinical care services. Topics may include feedback regarding the existing services as well as ideas regarding new innovative programs under development or raising awareness regarding the priorities or unmet needs of families and patients at the MAC. The council is comprised of family caregivers who care, or have cared, for persons with dementia.

Alzheimer’s Disease Trial with Aducanumab

The primary purpose of this study is to find out whether aducanumab has the potential to be a helpful treatment that slows down disease progression in subjects with early Alzheimer’s disease (AD) by comparing it to placebo and to evaluate its safety (side effects), and to find out more about aducanumab.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Biogen
  • Recruiting?: Yes
  • Official study title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease

Progressive Supranuclear Palsy Trial with C2N-8E12

The primary purpose of this study is to determine the safety, tolerability, and maximally tolerated dosage of C2N-8E12, and anti-tau monoclonal antibody. C2N-8E12 is an immunotherapy (antibody) drug designed to bind to and to remove tau protein. The tau protein is believed to build up to abnormally high levels in the brains of individuals with PSP. This abnormal accumulation is associated with clinical progression of the disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: C2N Diagnostics
  • Recruiting?: No
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects with Progressive Supranuclear Palsy

Progressive Supranuclear Palsy Trial with BMS-986168

The primary purpose of this study is to see how safe and well tolerated the study drug BMS-986168 is at different drug amounts in patients with PSP and to measure the amount of study drug in subject’s blood and cerebrospinal fluid (CSF) after taking the drug.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Bristol-Myers Squibb Company (BMS)
  • Recruiting?: No
  • Official study title: A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of Intravenously Administered BMS-986168 in Patients with Progressive Supranuclear Palsy (PSP)
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