hiv

HIV

Edgar Busovaca

Imaging Core Associate

Edgar Busovaca works with the acquisition, archiving and analysis of MRI data within the MAC. His primary projects are Dr. Victor Valcour's investigations in local individuals aging with HIV and neuroAIDS research in Thailand.

Prior to becoming a part of the MAC, Edgar acquired a BA degree in 2009 from the University of California, Berkeley in cognitive science. As a student, Edgar studied both computer science and neuroscience and also assisted research in numerical reasoning, and later, the neurodevelopment of reasoning ability. He hopes to carry his research experiences forward into a graduate program in cognitive neuroscience.

In his spare time, Edgar is an avid cyclist and music enthusiast.

Anna M. Karydas

Genetics and Specimens Project Manager

Anna Karydas joined the Memory and Aging Center in 2005 to support research activities investigating genetic causes of neurodegenerative diseases. She manages our laboratory specimens, genetic samples and genetic collaborations.

Brianne Bettcher, PhD

Assistant Professor

Brianne Bettcher completed her PhD degree in clinical psychology, with a concentration in neuroscience, from Temple University in 2010. During her time at Temple, she developed her research on error monitoring processes in individuals diagnosed with a dementia. Her research addressed how deficits in error monitoring affect an individual's capacity to carry out activities of daily living and function autonomously. She also developed an intervention strategy to train everyday task knowledge and demonstrated its efficacy for improving error detection. She completed her internship in clinical neuropsychology at the Palo Alto VA Hospital.

Currently, Dr. Bettcher is an Assistant Professor in Neurology and works as a neuropsychologist at the Memory and Aging Center. Her research focuses on the role of inflammation in cognitive aging and utilizes cognitive neuroscience techniques to understand how vascular and inflammatory risk factors may impact brain structure. Her research is funded by an NIH/NIA K23 Career Development Award to study the relationship between peripheral inflammation, cognitive functions and white matter microstructure in healthy, community dwelling older adults.

Lauren Wendelken

Project Analyst

Lauren Wendelken graduated from Boston University in 2001 with a BA degree in neuropsychology. She completed her undergraduate thesis work under the guidance of Dr. Howard Eichenbaum, and her work in his lab focused on the neurobiology of memory in animal behavioral models. She went on to graduate school at Albert Einstein College of Medicine in New York, where she joined Dr. Peter Davies' lab and earned an MS degree from the neuroscience department. Her research at Einstein focused on Alzheimer’s disease, and specifically the role of phosphorylated tau protein in neuronal pathology. After completing her master’s degree, Lauren took a hiatus from research and went to work running the New York office of an international literary agency. During her three year stint in publishing, Lauren revived her dormant French language skills and became familiar with reading habits around the world.

Lauren joined the Memory and Aging Center at UCSF in October of 2010. She works in Dr. Victor Valcour’s lab where she helps to coordinate local research into HIV dementia and aging with HIV as well as ongoing collaborations with the Thai Red Cross and the U.S. Army conducting neuroAIDS research in Thailand.

HIV and Aging

The purpose of this study is to determine if insulin resistance causes a unique pattern of cognitive impairment, study the effects of HIV on cognition in people over 60 years of age and study the corresponding neurological changes (via MRI imaging and volumetric analysis).

Summary

  • Study director: Victor Valcour, MD
  • Sponsors: The HIV Over 60 Cohort Study at the Memory and Aging Center is supported by an UCSF REAC Award and a NIH K24 Award
  • Recruiting?: Yes, we are actively recruiting patients from the greater San Francisco Bay Area
    • Main Places of Recruitment:
      • Physician Referrals
      • AIDS/HIV foundations
      • Infectious Disease Medical Offices
      • Hospitals

Frequently Asked Questions (FAQ)

Before you or your loved one join a research trial or study, your doctor should talk to you about what it's like to be in a trial and describe the pros and cons of participating. If you are interested, someone from the clinical trial staff will explain the details of the study, risks and benefits, and your rights as a participant, including your right to withdraw from the study at any point. Once all your questions have been answered, they will ask you to sign an informed consent to participate.

Choosing to participate in a clinical trial or research study is an important personal decision. The following frequently asked questions (FAQ) provide detailed information about clinical trials and were modified from the NIH Clinical Trials website, the UCSF Human Subjects Protection Program Website and the National Institute on Aging Alzheimer’s Disease website.

HIV-Related Cognitive Impairment

The human immunodeficiency virus (HIV) causes chronic inflammation throughout the body and brain. Without treatment, over 50% of subjects will develop clinically relevant central nervous system (CNS) symptoms. While antiretroviral therapies that reduce inflammation have greatly decreased the frequency of dementia in HIV, milder forms of impairment remain frequent.

What is HIV-related cognitive impairment?

The Human Immunodeficiency Virus (HIV) can infect the brain and impair central nervous system (CNS) function. With the advent of antiretroviral therapies, the most severe forms of HIV-associated dementia significantly decreased in prevalence. The subtler forms of HIV-associated neurocognitive disorders, however, remain frequent.

The major focus of our research is the impact of HIV on the central nervous system and cognitive functioning. Cognitive impairment in HIV is categorized into three groups—

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