The human immunodeficiency virus (HIV) causes chronic inflammation throughout the body and brain. Without treatment, over 50% of subjects will develop clinically relevant central nervous system (CNS) symptoms. While antiretroviral therapies that reduce inflammation have greatly decreased the frequency of dementia in HIV, milder forms of impairment remain frequent.
What is HIV-related cognitive impairment?
The Human Immunodeficiency Virus (HIV) can infect the brain and impair central nervous system (CNS) function. With the advent of antiretroviral therapies, the most severe forms of HIV-associated dementia significantly decreased in prevalence. The subtler forms of HIV-associated neurocognitive disorders, however, remain frequent.
The major focus of our research is the impact of HIV on the central nervous system and cognitive functioning. Cognitive impairment in HIV is categorized into three groups—