Huntington disease (HD) is a progressive, neurodegenerative disorder typically characterized by involuntary movements (chorea), behavioral and personality changes and cognitive decline (dementia). It is caused by a dominantly inherited gene mutation that can be passed down from generation to generation. HD is an illness with profound neurological and psychiatric features.
What is Huntington disease (HD)?
Huntington disease (HD) results from degeneration of neurons of structures deep within the brain, the basal ganglia, which are responsible for movement and coordination. Structures and circuitry responsible for thought, perception, emotions and memory are also affected, likely due to connections from the basal ganglia to the frontal lobes. Subsequently, there is great variability in the expression of HD, even within the same family.