Chronic Inflammation in Healthy Aging and MCI

Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program. Participants who have memory concerns and want to volunteer for research on dementia should first join the Alzheimer’s Disease Research Center (ADRC). These programs involve a single visit every 15 months and will enable you to get involved in other related research projects, like this study, if you’re interested.


Purpose of the Study

This is a longitudinal study to investigate possible ways in which inflammation and measures of brain health interact in both healthy aging and populations affected by mild cognitive impairment.

Study Details

Inclusion Criteria:

  • Normal aging cohort: Volunteers between the ages 50–100 with minor or no memory problems involved in the Healthy Aging study.
  • MCI cohort: Volunteers between the ages 50–100 with a diagnosis of MCI involved in the ADRC.

Exclusion Criteria:

  • Major psychiatric disorder or substance abuse/dependence
  • Neurological conditions affecting cognition (e.g., a diagnosis of Alzheimer’s disease or Parkinson’s disease with an exception for a diagnosis of MCI within the MCI group)
  • Significant current illness, acute or chronic (e.g., cancer, renal failure, respiratory failure)
  • Factors that would preclude the subject from getting an MRI scan (pacemaker, ferromagnetic material in soft tissue)

What to Expect

Testing: Computer-based tests measuring attention and reaction time, paper and pencil cognitive testing, and brain MRI

The Frequency of Visits: One visit every 30 months longitudinally (3 hours of testing and 1-hour MRI scan)

Materials Needed Before Evaluation: None

Costs: No costs will be charged for any of the study procedures. Parking will be validated for the 1625 Owens Street Garage or 1630 Third Street Garage at the UCSF Mission Bay campus for all study visits. There is no monetary compensation for participation.

Contact Information

If you are interested in participating in this study or have any questions, please contact the study coordinator, Sophia Weiner-Light, at [email protected] or 415.502.7149.