Michael Geschwind, MD, PhD

Professor
+1 415 476-2900

Michael Geschwind, MD, PhD, is a professor of neurology at the UCSF Weill Institute for Neurosciences and a clinician-researcher at the UCSF Edward and Pearl Fein Memory and Aging Center. Dr. Geschwind specializes in the evaluation, management, and treatment of rapidly progressive dementias, movement disorders, and neurogenetic conditions.

Dr. Geschwind earned his MD and PhD in neuroscience through the NIH-sponsored Medical Scientist Training Program at Albert Einstein College of Medicine in New York. He completed his internship in internal medicine at UCLA Medical Center, followed by a residency in neurology at Johns Hopkins University School of Medicine. He then pursued a fellowship in behavioral neurology at UCSF, where he has remained a vital part of the Fein Memory and Aging Center team.

Dr. Geschwind is widely recognized for his expertise in rapidly progressive dementias, including prion diseases such as Creutzfeldt-Jakob disease (CJD) and antibody-mediated encephalopathies. He helped establish the first U.S. program dedicated to assessing rapidly progressive dementias at UCSF and led the country’s first treatment study for CJD. He also has active research and clinical interests in movement disorders, such as Huntington’s disease, spinocerebellar ataxia (SCA), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA), as well as neurogenetic disorders like CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).

Dr. Geschwind co-directs the UCSF Huntington’s Disease (HD) Center, designated as a Huntington’s Disease Society of America Center of Excellence, and serves as an investigator for studies on Huntington’s disease, SCA, and MSA. He also co-directs the UCSF Autoimmune Encephalopathy Clinic, where patients with antibody-mediated encephalopathies are assessed and treated.

An accomplished teacher and mentor, Dr. Geschwind is deeply involved in the training of medical students, residents, and fellows at UCSF. He lectures nationally and internationally on dementia and movement disorders, making significant contributions to the field through his teaching, research, and clinical care.

Publications

Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes.

Küçükali F, Hill E, Watzeels T, Hummerich H, Campbell T, Darwent L, Collins S, Stehmann C, Kovacs GG, Geschwind MD, Frontzek K, Budka H, Gelpi E, Aguzzi A, van der Lee SJ, van Duijn CM, Liberski PP, Calero M, Sanchez-Juan P, Bouaziz-Amar E, Laplanche JL, Haïk S, Brandel JP, Mammana A, Capellari S, Poleggi A, Ladogana A, Tiple D, Zafar S, Booth S, Jansen GH, Areškeviciute A, Lund EL, Glisic K, Parchi P, Hermann P, Zerr I, Safar J, Gambetti P, Appleby BS, Collinge J, Sleegers K, Mead S

The Natural History Study and Biomarker Collection of the Clinical Research Consortium for the Study of Cerebellar Ataxia (CRC-SCA).

Lin Y, Amokrane N, Worley S, Moore LR, Rosen A, Crespo LP, Trace K, Ashizawa T, Billnitzer A, Perlman S, Fisher A, Bushara K, Geschwind MD, Dietiker C, Gomez CM, Padmanaban M, Opal P, Akhtar RS, Paulson H, Srinivasan S, Ferng A, Ferrari F, Onyike CU, Fishman A, Ying S, Paul A, Schmahmann JD, Stephen CD, Gupta A, Lin CC, Subramony SH, Burns M, Wilmot G, Duquette A, Zesiewicz T, Davis MY, Hamedani AG, Vizcarra JA, Pulst SM, Primeaux S, Öz G, Shakkottai VG, Rosenthal LS, Kuo SH, CRC-SCA Consortium

Genome wide association study of clinical duration and age at onset of sporadic CJD.

Hummerich H, Speedy H, Campbell T, Darwent L, Hill E, Collins S, Stehmann C, Kovacs GG, Geschwind MD, Frontzek K, Budka H, Gelpi E, Aguzzi A, van der Lee SJ, van Duijn CM, Liberski PP, Calero M, Sanchez-Juan P, Bouaziz-Amar E, Laplanche JL, Haïk S, Brandel JP, Mammana A, Capellari S, Poleggi A, Ladogana A, Pocchiari M, Zafar S, Booth S, Jansen GH, Areškeviciute A, Løbner Lund E, Glisic K, Parchi P, Hermann P, Zerr I, Appleby BS, Safar J, Gambetti P, Collinge J, Mead S

Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies.

Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.

Jones E, Hummerich H, Viré E, Uphill J, Dimitriadis A, Speedy H, Campbell T, Norsworthy P, Quinn L, Whitfield J, Linehan J, Jaunmuktane Z, Brandner S, Jat P, Nihat A, How Mok T, Ahmed P, Collins S, Stehmann C, Sarros S, Kovacs GG, Geschwind MD, Golubjatnikov A, Frontzek K, Budka H, Aguzzi A, Karamujic-Comic H, van der Lee SJ, Ibrahim-Verbaas CA, van Duijn CM, Sikorska B, Golanska E, Liberski PP, Calero M, Calero O, Sanchez-Juan P, Salas A, Martinón-Torres F, Bouaziz-Amar E, Haïk S, Laplanche JL, Brandel JP, Amouyel P, Lambert JC, Parchi P, Bartoletti-Stella A, Capellari S, Poleggi A, Ladogana A, Pocchiari M, Aneli S, Matullo G, Knight R, Zafar S, Zerr I, Booth S, Coulthart MB, Jansen GH, Glisic K, Blevins J, Gambetti P, Safar J, Appleby B, Collinge J, Mead S

HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD).

Carlozzi NE, Schilling SG, Lai JS, Paulsen JS, Hahn EA, Perlmutter JS, Ross CA, Downing NR, Kratz AL, McCormack MK, Nance MA, Quaid KA, Stout JC, Gershon RC, Ready RE, Miner JA, Barton SK, Perlman SL, Rao SM, Frank S, Shoulson I, Marin H, Geschwind MD, Dayalu P, Goodnight SM, Cella D

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA