The goal of this study is to identify the best methods of analysis for tracking PSP and CBD over time.
The goal of this study is to support the development of FTLD therapies through a multi-site research consortium headquartered at UCSF. The study aims to determine the clinical, genetic, and biomarker profiles of FTLD syndromes where there is a strong correlation between clinical syndrome and underlying pathology (FTD-ALS, PSP, and semantic variant PPA (svPPA)). The study also aims to determine the natural history of familial FTLD using novel clinical measures.
This study seeks to determine the best neuroimaging methods and biomarkers to track the progression of Alzheimer’s disease (AD). The goal of the study is to produce a roadmap of the disease that can aid clinical trials studies.
In this study, investigators use skin cells from people and transform them first into pluripotent stem cells and ultimately into neurons that are genetically identical to the affected neurons in the patient.
The primary goal of this study is to develop and test methods for differentiating Creutzfeldt-Jakob disease (CJD) from other diseases and to learn how to diagnose CJD as early as possible.
Approximately 5% of patients with Alzheimer’s disease develop symptoms before age 65, without a known genetic cause. In this study, we use comprehensive clinical evaluations, cerebrospinal fluid (optional) and genetic analyses, and MRI and PET imaging to improve our understanding and diagnosis of early onset and atypical Alzheimer’s disease.
The goal of this study is to learn how Parkinson’s disease affects social and emotional behavior. For example, we aim to assess how participants respond to different kinds of emotional stimuli and whether they can recognize emotions in other people. In addition, we study the emotional behavior of caregivers and their experience of caring for a loved one with Parkinson’s disease.
The purpose of this study is to help understand how eye movements are created in the brain. Understanding the changes in eye movements that occur with normal aging and neurological diseases may help in diagnosis and future treatment of these diseases.
The purpose of this study is to learn about the mechanisms of eye movement control and visual perception, as well as how these functions may change with different neurologic diseases.
The goal of this study is to identify rare genetic variants as risk factors for progressive supranuclear palsy (PSP). By studying patients with PSP and their relatives affected by related conditions, we hope to identify genes that are involved in PSP and related disorders.
In this study, the investigators are examining how brain activity relates to autonomic responses (i.e., heart rate, digestion, respiration rate, salivation, perspiration) in healthy subjects and patients with frontotemporal dementia (FTD), Alzheimer's disease (AD) and other closely related neurodegenerative diseases.
The purpose of this study is to help understand the clinical, emotional, genetic and imaging features of frontotemporal dementia (FTD) as well as the neuropathology of frontotemporal lobar degeneration (FTLD) and related disorders.
The purpose of this study is to learn more about how a healthy person ages and what changes in the brain occur with aging.
The purpose of this study is to determine if insulin resistance causes a unique pattern of cognitive impairment, study the effects of HIV on cognition in people over 60 years of age and study the corresponding neurological changes (via MRI imaging and volumetric analysis).
Enroll-HD is a coordinated worldwide effort by approximately 45 Huntington Study Group (HSG) research centers to collect ongoing information from individuals who are affected by HD and those who are part of an HD family.
The purpose of this study is to identify characteristic patterns of social and emotional cognition to improve both early diagnosis of different neurodegenerative diseases and our knowledge of normal function in healthy adults.
The goal of this study is to learn more about the levels of tau and amyloid proteins in brains of people who have Parkinson’s disease.
PREDICT-HD aims to refine the prediction of HD onset using longitudinal measures, find and validate tests clinicians can use when detecting early symptoms, and improve our knowledge of illness markers.
This study seeks to determine the best neuroimaging methods to diagnose and track the progression of frontotemporal dementia (FTD) and compare these results to other biomarkers of the disease. Objective outcome measures are essential to test possible therapeutics in clinical trials.
The purpose of this study is to collect information from various tests of brain function with the goal of improving early detection and clinical care for patients with dementia.
This is a longitudinal study which aims at identifying the cognitive mechanisms and neural structures that underlie the decline in executive functioning observed in normal aging. Participants who want to volunteer for research on healthy aging should first join the Healthy Aging Program.
The Memory and Aging Center is currently recruiting participants with Parkinson’s disease (PD) for involvement in several different research projects at UC San Francisco and UC Berkeley.
The purpose of this study is to determine how sleep is affected in both healthy aging and neurodegenerative processes. The study aims to determine whether sleep quality alters performance on cognitive tasks in older adults and whether this relationship changes with mild to moderate cognitive impairments.