Panos Theofilas, PhD

Assistant Professor
+1 415 502-7174
Fields of Interest: 

Dr. Theofilas is Assistant Professor at the Memory and Aging Center, UCSF. He obtained his bachelor and masters’ degrees in Neuroscience at the University of Edinburgh, UK, and his doctorate at the University of Bonn, Germany, studying apoptosis signaling pathways, mitochondria dysfunction and excitotoxicity in animal models of epilepsy.

In 2012, Dr. Theofilas joined Lea Grinberg’s lab at UCSF to study a network of subcortical nuclei of the isodentritic core in the human brainstem that shows the earliest neurofibrillary changes in individuals with Alzheimer’s disease. He conducted integrative analyses of neuronal loss and tangle accumulation in the locus coeruleus and dorsal raphe nucleus using unbiased stereology with immunohistochemistry and advanced graphics computing for three-dimensional brainstem volume reconstructions.

Dr. Theofilas is currently a principal investigator in a study focusing on cell death pathways and their relationship to tau pathology in patients with AD and iPSC culture models. He is particularly interested in proteasome and apoptosis/caspase-related pathways and how these correlate to tau post-translational modifications, tau aggregation, and neurotoxicity in AD.

Publications: 

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

Stem cell reports

Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S

Profound degeneration of wake-promoting neurons in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.

Nature chemical biology

Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Journal of neuropathology and experimental neurology

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Neurobiology of aging

Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.

Neuropathology and applied neurobiology

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT

Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding.

Journal of neuroscience methods

Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT

Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis.

Journal of Alzheimer's disease : JAD

Theofilas P, Dunlop S, Heinsen H, Grinberg LT

A novel approach for integrative studies on neurodegenerative diseases in human brains.

Journal of neuroscience methods

Theofilas P, Polichiso L, Wang X, Lima LC, Alho AT, Leite RE, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.

Acta neuropathologica

Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

Cerebral cortex (New York, N.Y. : 1991)

Diógenes MJ, Neves-Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, Lopatár J, Ribeiro JA, Maggi L, Frenguelli BG, Limatola C, Boison D, Sebastião AM

Effect of (S)-3,5-DHPG on microRNA expression in mouse brain.

Experimental neurology

Lusardi TA, Thompson SJ, MacDonald IC, Lan JQ, Theofilas P, Saugstad JA

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors.

The Journal of clinical investigation

Masino SA, Li T, Theofilas P, Sandau US, Ruskin DN, Fredholm BB, Geiger JD, Aronica E, Boison D

Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.

Epilepsia

Theofilas P, Brar S, Stewart KA, Shen HY, Sandau US, Poulsen D, Boison D

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.

Seizure

Van Dycke A, Raedt R, Verstraete A, Theofilas P, Wadman W, Vonck K, Boison D, Boon P

The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death.

Journal of neuropathology and experimental neurology

Theofilas P, Bedner P, Hüttmann K, Theis M, Steinhäuser C, Frank S

The role of the hippocampus in object recognition in rats: examination of the influence of task parameters and lesion size.

Behavioural brain research

Ainge JA, Heron-Maxwell C, Theofilas P, Wright P, de Hoz L, Wood ER