The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation. Hodul M, Ganji R, Dahlberg CL, Raman M, Juo P The Journal of biological chemistry
A synthetic heparinoid blocks Tau aggregate cell uptake and amplification. Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI The Journal of biological chemistry
Parkinson's disease and multiple system atrophy have distinct a-synuclein seed characteristics. Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI The Journal of biological chemistry
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus a-synuclein and ß-amyloid aggregates. Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI The Journal of biological chemistry
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI The Journal of biological chemistry
Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. Holmes BB, Diamond MI The Journal of biological chemistry
An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI The Journal of biological chemistry
Trans-cellular propagation of Tau aggregation by fibrillar species. Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI The Journal of biological chemistry
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J The Journal of biological chemistry
Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. Van Itallie CM, Mitic LL, Anderson JM The Journal of biological chemistry
