Claire Clelland, MD, PhD

Assistant Adjunct Professor
Fields of Interest: 
Genetics
CRISPR
Basic Science Research

The Clelland laboratory aims to develop cures for dementia and related neurodegenerative diseases. She is focused on single-gene (monogenic) causes of frontotemporal dementia and amyotrophic lateral sclerosis, such as mutations in the C9orf72 gene. She and her team develop CRISPR gene editing approaches in relevant cell types derived from human iPSCs and are working to develop better cell model systems of disease.

Publications: 

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

Proceedings of the National Academy of Sciences of the United States of America

Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Proceedings of the National Academy of Sciences of the United States of America

Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD

Validated assays for the quantification of C9orf72 human pathology.

Scientific reports

Salomonsson SE, Maltos AM, Gill K, Aladesuyi Arogundade O, Brown KA, Sachdev A, Sckaff M, Lam KJK, Fisher IJ, Chouhan RS, Van Laar VS, Marley CB, McLaughlin I, Bankiewicz KS, Tsai YC, Conklin BR, Clelland CD

Novel avenues of tau research.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC

Functional characterization of Alzheimer's disease genetic variants in microglia.

Nature genetics

Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MY, Ren X, Cui X, Song M, Liu H, Chen C, Eng N, Ravichandran M, Sun Y, Lee D, Van Buren E, Jiang MZ, Chan CSY, Ye CJ, Perera RM, Gan L, Li Y, Shen Y

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.

Nature neuroscience

Dr?ger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M

Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro.

Biomaterials

Chun C, Smith AST, Kim H, Kamenz DS, Lee JH, Lee JB, Mack DL, Bothwell M, Clelland CD, Kim DH

Microglial microRNAs mediate sex-specific responses to tau pathology.

Nature neuroscience

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.

Proceedings of the National Academy of Sciences of the United States of America

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L

Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.

Neurobiology of Disease

Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA

Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache.

Cephalalgia : an international journal of headache

Clelland CD, Zheng Z, Kim W, Bari A, Pouratian N

Comprehensive review of stereotactic radiosurgery for medically and surgically refractory pituitary adenomas.

Surgical neurology international

Kim W, Clelland C, Yang I, Pouratian N

A functional role for adult hippocampal neurogenesis in spatial pattern separation.

Science (New York, N.Y.)

Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ

Cell therapy in Huntington disease.

Neurosurgical focus

Clelland CD, Barker RA, Watts C