Molly Hodul, PhD

Postdoctoral Scholar
[email protected]
Fields of Interest: 
Basic Science Research

Molly studied Neuroscience and Psychology at the University of California, Los Angeles. She then completed her PhD degree with Professor Peter Juo at Tufts University, where she investigated the regulation of the AMPA-type glutamate receptor by its deubiquitinating enzyme USP-46 in C. elegans. She identified two novel mechanisms by which USP-46 is stabilized and activated by two WD40-repeat proteins, WDR-48 and WDR-20, to promote AMPAR abundance and recycling to the neuronal surface. In the Kao lab, Molly will continue her research in protein homeostasis and degradation in C. elegans. Her project focuses on the interaction between progranulin and prosaposin and their role in lysosomal function and neurodegeneration.

Publications: 

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Molecular neurodegeneration

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW

Mutations in a-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Molecular neurodegeneration

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW

The WD40-Repeat Protein WDR-20 and the Deubiquitinating Enzyme USP-46 Promote Cell Surface Levels of Glutamate Receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hodul M, Rennich BJ, Luth ES, Dahlberg CL, Juo P

VER/VEGF receptors regulate AMPA receptor surface levels and glutamatergic behavior.

PLoS genetics

Luth ES, Hodul M, Rennich BJ, Riccio C, Hofer J, Markoja K, Juo P