Lorenzo Pasquini, PhD

Asst Professor in Residence
Fields of Interest: 

Dr. Lorenzo Pasquini joined the Seeley lab in November 2016 as a postdoctoral fellow. He graduated in Neuroscience and Public Health at the Ludwig-Maximilan University of Munich. He obtained a PhD degree from the Technical University of Munich, where he worked under the mentorship of Dr. Christian Sorg at the Neuroimaging Center, studying large-scale brain network dysfunctions in Alzheimer’s disease, with a specific focus on multimodal neuroimaging and intrinsic activity of the medial temporal lobes.

Among other projects, he has collaborated with the Psychiatry Department of King’s College London on a project investigating neurological determinants of dementia in low and middle income countries (10/66 Research Group), and with the Brain Institute in Natal on a fMRI project investigating the effects of the psychedelic substance Ayahuasca on brain activity. Lorenzo’s main interests are to investigate the link between neuropathology and neuroimaging, and to develop subject tailored neuroimaging biomarkers for frontotemporal dementia.

Publications: 

Functional network collapse in neurodegenerative disease.

bioRxiv : the preprint server for biology

Brown JA, Lee AJ, Fernhoff K, Pistone T, Pasquini L, Wise AB, Staffaroni AM, Mandelli ML, Lee SE, Boxer AL, Rankin KP, Rabinovici GD, Tempini MLG, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Alzheimer’s Disease Neuroimaging Initiative (ADNI)

FTLD targets brain regions expressing recently evolved genes.

medRxiv : the preprint server for health sciences

Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW

Network connectivity alterations across the MAPT mutation clinical spectrum.

Annals of neurology

Zhang L, Flagan TM, Häkkinen S, Chu SA, Brown JA, Lee AJ, Pasquini L, Mandelli ML, Gorno-Tempini ML, Sturm VE, Yokoyama JS, Appleby BS, Cobigo Y, Dickerson BC, Domoto-Reilly K, Geschwind DH, Ghoshal N, Graff-Radford NR, Grossman M, Hsiung GR, Huey ED, Kantarci K, Lario Lago A, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Ramos EM, Roberson ED, Tartaglia MC, Toga AW, Weintraub S, Wszolek ZK, Forsberg LK, Heuer HW, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Lee SE, ARTFL/LEFFTDS/ALLFTD Consortia

Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia.

JAMA neurology

Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Ill?n-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind DH, Spina S, Grinberg LT, Miller ZA, Kramer JH, Rosen H, Gorno-Tempini ML, Rabinovici G, Seeley WW, Miller BL

Dynamic autonomic nervous system states arise during emotions and manifest in basal physiology.

Psychophysiology

Pasquini L, Noohi F, Veziris CR, Kosik EL, Holley SR, Lee A, Brown JA, Roy ARK, Chow TE, Allen I, Rosen HJ, Kramer JH, Miller BL, Saggar M, Seeley WW, Sturm VE

Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Pasquini L, Fryer SL, Eisendrath SJ, Segal ZV, Lee AJ, Brown JA, Saggar M, Mathalon DH

A dynamic gradient architecture generates brain activity states.

NeuroImage

Brown JA, Lee AJ, Pasquini L, Seeley WW

Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta-analysis of 73 studies.

Alzheimer's & dementia (Amsterdam, Netherlands)

Kamalian A, Khodadadifar T, Saberi A, Masoudi M, Camilleri JA, Eickhoff CR, Zarei M, Pasquini L, Laird AR, Fox PT, Eickhoff SB, Tahmasian M

Local neurodegeneration and global connectivity adaptation across the FTD-AD spectrum.

Alzheimer's & Dementia

Jesse A. Brown, Alex Jihun Lee, Lorenzo Pasquini, Adit Friedberg, Gil D. Rabinovici, Joel H Kramer, Maria Luisa Gorno Tempini, Howard J. Rosen, Bruce L. Miller, William W. Seeley

A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP.

Brain pathology (Zurich, Switzerland)

Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, De Paula Franca Resende E, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT

Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia.

Cerebral cortex (New York, N.Y. : 1991)

Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW

Subacute effects of the psychedelic ayahuasca on the salience and default mode networks.

Journal of psychopharmacology (Oxford, England)

Pasquini L, Palhano-Fontes F, Araujo DB

Questions and controversies in the study of time-varying functional connectivity in resting fMRI.

Network neuroscience (Cambridge, Mass.)

Lurie DJ, Kessler D, Bassett DS, Betzel RF, Breakspear M, Kheilholz S, Kucyi A, Liégeois R, Lindquist MA, McIntosh AR, Poldrack RA, Shine JM, Thompson WH, Bielczyk NZ, Douw L, Kraft D, Miller RL, Muthuraman M, Pasquini L, Razi A, Vidaurre D, Xie H, Calhoun VD

State and trait characteristics of anterior insula time-varying functional connectivity.

NeuroImage

Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW

Human subsystems of medial temporal lobes extend locally to amygdala nuclei and globally to an allostatic-interoceptive system.

NeuroImage

Ruiz-Rizzo AL, Beissner F, Finke K, Müller HJ, Zimmer C, Pasquini L, Sorg C

Progress update from the hippocampal subfields group.

Alzheimer's & dementia (Amsterdam, Netherlands)

Olsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, Chakravarty MM, Chételat G, de Flores R, DeKraker J, Ding SL, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Lee Shing Y, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM

Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages.

Journal of Alzheimer's disease reports

Pasquini L, Rahmani F, Maleki-Balajoo S, La Joie R, Zarei M, Sorg C, Drzezga A, Tahmasian M

Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

NeuroImage. Clinical

Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study.

Human brain mapping

Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V

Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.

Acta neuropathologica

Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW

Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C

Decoupling of Local Metabolic Activity and Functional Connectivity Links to Amyloid in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Scherr M, Pasquini L, Benson G, Nuttall R, Gruber M, Neitzel J, Brandl F, Sorg C

Individual Correspondence of Amyloid-ß and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C

Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.

Alzheimer's & dementia (Amsterdam, Netherlands)

Nuttall R, Pasquini L, Scherr M, Sorg C

Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease.

Frontiers in neurology

Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H

AMYLOID PATHOLOGY DECOUPLES LOCAL MEAN SYNAPTIC ACTIVITY FROM ITS INTER-REGIONAL FUNCTIONAL CONNECTIVITY.

Alzheimer's & Dementia

Christian Sorg, Lorenzo Pasquini, Igor Yakushev, Timo Grimmer, Martin Scherr

GLOBAL AND LOCAL INTERACTIONS BETWEEN AMYLOID-B PATHOLOGY AND INTRINSIC CONNECTIVITY ALONG THE SPECTRUM OF ALZHEIMER’S DISEASE.

Alzheimer's & Dementia

Lorenzo Pasquini, Gloria Benson, Martin Scherr, Igor Yakushev, Timo Grimmer, Nicholas Myers, Michel J. Grothe, Christian Sorg, Alzheimer's Disease Neuroimaging Initiative

Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia.

Journal of Alzheimer's disease : JAD

Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C

The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease.

Neurology

Tahmasian M, Pasquini L, Scherr M, Meng C, Förster S, Mulej Bratec S, Shi K, Yakushev I, Schwaiger M, Grimmer T, Diehl-Schmid J, Riedl V, Sorg C, Drzezga A

Link between hippocampus' raised local and eased global intrinsic connectivity in AD.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C

Disrupted Intrinsic Networks Link Amyloid-ß Pathology and Impaired Cognition in Prodromal Alzheimer's Disease.

Cerebral cortex (New York, N.Y. : 1991)

Koch K, Myers NE, Göttler J, Pasquini L, Grimmer T, Förster S, Manoliu A, Neitzel J, Kurz A, Förstl H, Riedl V, Wohlschläger AM, Drzezga A, Sorg C

WITHIN-PATIENT CORRESPONDENCE OF AMYLOID-B AND INTRINSIC NETWORK CONNECTIVITY IN ALZHEIMER'S DISEASE.

Alzheimer's & Dementia

Christian Sorg, Afra M. Wohlschläger, Alexander Drzezga, Alexander Kurz, Hans Förstl, Lorenzo Pasquini, Nicholas Myers, Timo Grimmer, Valentin Riedl

Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons.

Brain connectivity

Pasquini L, Tonch A, Plant C, Zherdin A, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschäger A, Riedl V, Sorg C

Within-patient correspondence of amyloid-ß and intrinsic network connectivity in Alzheimer's disease.

Brain : a journal of neurology

Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C