Alexander Ehrenberg, PhD

Alexander Ehrenberg, PhD
Assistant Researcher
Fields of Interest

Dr. Ehrenberg is an investigator specializing in neurodegenerative disease biology and therapeutic development. His background spans neuropathology, genetics, and cell biology with a particular focus on the mechanisms underlying selective vulnerability – why certain cells are vulnerable to neurodegenerative diseases and others are not. His team combines neuropathology, functional genomics, and advanced histology/optical techniques such as spatial transcriptomics to discover novel disease mechanisms. They then leverage those mechanisms as targets for CRISPR-based therapeutic development. He and his team span the UCSF Edward and Perl Fein Memory and Aging Center and the Innovative Genomics Institute at UC Berkeley.

Publications

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.

Rae RJ, Alberhasky JMH, Baillet M, Bangasser DA, Belloy ME, Berry AS, Berteotti C, Bow H, Buckley R, Caldwell JZK, Carpi M, Clark BJ, Ciampa CJ, Conley AC, Dahl MJ, Donaldson ZR, Ehrenberg AJ, Einstein G, Falgàs N, Fenlon HA, Fitzhugh MC, Froemke RC, Gallay C, Grinberg LT, Hamilton DA, Hasan Z, Huarte OU, Jabeen S, Jacobs HIL, Kolling LJ, Koops EA, Lenzoni S, Liguori C, Manca R, Marcinkiewcz CA, Omoluabi T, Oria R, Orsini CA, Ortega NE, Pa J, Pentkowski NS, Pereira JB, Ramos R, Sargin D, Satpati A, Selles MC, Seto M, Shaik SM, Sindi S, Son G, Ucheagwu V, Van Egroo M, Yuan Q, Kelberman MA

Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery.

Manohar BD, Travis M, Munjal V, Baehr CM, Rahnama LMA, Kang MH, Haddad RF, Asija K, Noel EA, Peddireddy N, Chouhan RS, Sharma R, Wyman SK, Krishnappa N, Killebrew DA, Li SH, Snow KJ, Byrne AK, Boosani CS, Otero PA, Bringas J, O'Brien AA, Rocco MT, Zimmerly MP, Gray I, Sran GK, Patel MI, Seidensticker EF, Saville E, Gaitan Y, Schmelzle AL, Subramanyam PNB, Samaranch L, Green JA, Wells KD, Ehrenberg AJ, Murray SA, Clelland CD, Murthy N, Lonser RR, Hadaczek P, Van Laar VS, Bankiewicz KS, Wilson RC

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease.

Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T

Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi.

Richardson TE, Orr ME, Orr TC, Rohde SK, Ehrenberg AJ, Thorn EL, Christie TD, Flores-Almazan V, Afzal R, De Sanctis C, Maldonado-Díaz C, Hiya S, Canbeldek L, Kulumani Mahadevan LS, Slocum C, Samanamud J, Clare K, Scibetta N, Yokoda RT, Koenigsberg D, Marx GA, Kauffman J, Goldstein A, Selmanovic E, Drummond E, Wisniewski T, White CL, Goate AM, Crary JF, Farrell K, Alosco ML, Mez J, McKee AC, Stein TD, Bieniek KF, Kautz TF, Daoud EV, Walker JM

Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.

Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT

Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus.

Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, Pestal K, Frankino PA, Murley A, Nandakumar D, Stahl EC, Tsuchida CA, Gildea HK, Murdock AG, Hochstrasser ML, O'Brien E, Ciling A, Tsitsiklis A, Worden K, Dugast-Darzacq C, Hays SG, Barber CC, McGarrigle R, Lam EK, Ensminger DC, Bardet L, Sherry C, Harte A, Nicolette G, Giannikopoulos P, Hockemeyer D, Petersen M, Urnov FD, Ringeisen BR, Boots M, Doudna JA, IGI SARS-CoV-2 Testing Consortium

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery.

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT