Emily Paolillo

Emily Paolillo, PhD

Assistant Adjunct Professor
[email protected]
Fields of Interest: 
Neuropsychology

Emily Paolillo, PhD, is an Assistant Professor and neuropsychologist at the UCSF Memory and Aging Center. She obtained her PhD degree in Clinical Psychology (emphasis in Neuropsychology) from the SDSU/UCSD Joint Doctoral Program in 2021, which included a predoctoral clinical internship at VA Palo Alto Health Care System. Her program of research focuses on advancing real-world assessment of cognitive and everyday functioning in older adults in naturalistic settings, with the goal of improving early and sensitive detection of change in Alzheimer's disease and related dementias. This work often involves the development and validation of digital health tools.

Publications: 

Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.

Brain Communications

Casaletto KB, Saloner R, Kornak J, Staffaroni AM, Villeda S, Paolillo E, VandeBunte AM, Cadwallader CJ, Lario Lago A, Webb J, Chen C, Rascovsky K, Miyagawa T, Ramos EM, Masdeu JC, Pantelyat A, Tartaglia MC, Bozoki A, Pressman PS, Rademakers R, Kremers W, Darby R, Younes K, Pascual B, Ghoshal N, Lapid M, Mackenzie IRA, Li J, Hsiung GR, Hall JN, Yutsis MV, Litvan I, Henderson VW, Sivasankaran R, Worringer K, Domoto-Reilly K, Synder A, Loureiro J, Kramer JH, Heuer H, Forsberg LK, Rosen HJ, Boeve B, Rojas JC, Boxer AL

Feasibility and psychometric quality of smartphone administered cognitive ecological momentary assessments in women with metastatic breast cancer.

Digital health

Henneghan AM, Paolillo EW, Van Dyk KM, Franco-Rocha OY, Bang S, Tasker R, Kaufmann T, Haywood D, Hart NH, Moore RC

Characterizing cancer-related cognitive impairments and impact on quality of life in women with metastatic breast cancer.

Breast cancer research and treatment

Henneghan AM, Van Dyk KM, Haywood D, Patel M, Franco-Rocha OY, Bang S, Longley T, Tasker R, Kaufmann T, Paolillo EW, Moore RC, Hart NH

Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.

Alzheimer's & dementia : the journal of the Alzheimer's Association

VandeBunte AM, Lee H, Paolillo EW, Hsiung GR, Staffaroni AM, Saloner R, Tartaglia C, Yaffe K, Knopman DS, Ramos EM, Rascovsky K, Bozoki AC, Wong B, Domoto-Reilly K, Snyder A, Pressman P, Mendez MF, Litvan I, Fields JA, Galasko DR, Darby R, Masdeu JC, Pasqual MB, Honig LS, Ghoshal N, Appleby BS, Mackenzie IR, Heuer HW, Kramer JH, Boxer AL, Forsberg LK, Boeve B, Rosen HJ, Casaletto KB, ALLFTD Consortium

Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults.

Neurobiology of aging

You M, Lindbergh CA, La Joie R, Paolillo EW, Saloner R, Diaz V, Cotter DL, Walters S, Altendahl M, Staffaroni AM, Kramer JH, Gaynor LS, Casaletto KB

Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.

JMIR aging

Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, Darby RR, Day GS, Dickerson BC, Domoto-Reilly K, Elahi F, Fields JA, Ghoshal N, Graff-Radford N, G H Hall M, Honig LS, Huey ED, Lapid MI, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Mester C, Miyagawa T, Naasan G, Pascual B, Pressman P, Ramos EM, Rankin KP, Rexach J, Rojas JC, VandeVrede L, Wong B, Wszolek ZK, Boeve BF, Rosen HJ, Boxer AL, Staffaroni AM, ALLFTD Consortium

Associations of cerebrovascular disease and Alzheimer's disease pathology with cognitive decline: Analysis of the National Alzheimer's Coordinating Center Uniform Data Set.

Neurobiology of aging

Chatterjee A, Lee S, Diaz V, Saloner R, Sanderson-Cimino M, deCarli C, Maillard P, Hinman J, Vossel K, Casaletto KB, Staffaroni AM, Paolillo EW, Kramer JH

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.

Research square

Saloner R, Staffaroni A, Dammer E, Johnson ECB, Paolillo E, Wise A, Heuer H, Forsberg L, Lago AL, Webb J, Vogel J, Santillo A, Hansson O, Kramer J, Miller B, Li J, Loureiro J, Sivasankaran R, Worringer K, Seyfried N, Yokoyama J, Seeley W, Spina S, Grinberg L, VandeVrede L, Ljubenkov P, Bayram E, Bozoki A, Brushaber D, Considine C, Day G, Dickerson B, Domoto-Reilly K, Faber K, Galasko D, Geschwind D, Ghoshal N, Graff-Radford N, Hales C, Honig L, Hsiung GY, Huey E, Kornak J, Kremers W, Lapid M, Lee S, Litvan I, McMillan C, Mendez M, Miyagawa T, Pantelyat A, Pascual B, Paulson H, Petrucelli L, Pressman P, Ramos E, Rascovsky K, Roberson E, Savica R, Snyder A, Sullivan AC, Tartaglia C, Vandebergh M, Boeve B, Rosen H, Rojas J, Boxer A, Casaletto K

Neuropsychiatric profiles and cerebral amyloid burden in adults without dementia.

Dementia and geriatric cognitive disorders

Gontrum EQ, Paolillo EW, Lee S, Diaz V, Ehrenberg A, Saloner R, Mundada NS, La Joie R, Rabinovici G, Kramer JH, Casaletto K

Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden.

Alzheimer's research & therapy

Paolillo EW, Saloner R, VandeBunte A, Lee S, Bennett DA, Casaletto KB

The clinical utility of three frailty measures in identifying HIV-associated neurocognitive disorders.

AIDS (London, England)

Moore DJ, Sun-Suslow N, Nichol AA, Paolillo EW, Saloner R, Letendre SL, Iudicello J, Morgan EE

Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH

Moderating role of physical activity on hippocampal iron deposition and memory outcomes in typically aging older adults.

Neurobiology of aging

Lee SY, Paolillo EW, Saloner R, Cobigo Y, Diaz VE, Gontrum EQ, VandeBunte A, Chatterjee A, Tucker M, Kramer JH, Casaletto KB

Data-driven physical actigraphy patterns relate to cognitive and vascular health in older adults.

Experimental gerontology

Paolillo EW, Lee SY, VandeBunte A, Saloner R, Gaynor LS, Djukic N, Tsuei T, Cobigo Y, Kramer JH, Casaletto KB

Neuropsychiatric predictors of cognitive functioning over a one-year follow-up period in HIV.

Journal of affective disorders

Sundermann EE, Tang B, Kim M, Paolillo EW, Heaton RK, Moore RC

A longitudinal study of cannabis use and risk for cognitive and functional decline among older adults with HIV.

AIDS and behavior

Watson CW, Sundermann E, Helm J, Paolillo EW, Hong S, Ellis RJ, Letendre S, Marcotte TD, Heaton RK, Morgan EE, Grant I

Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB

Regional Vulnerability of the Corpus Callosum in the Context of Cardiovascular Risk.

Journal of geriatric psychiatry and neurology

VandeBunte AM, Fonseca C, Paolillo EW, Gontrum E, Lee SY, Kramer JH, Casaletto KB

Impact of PTSD and Obstructive Sleep Apnea on Cognition in Older Adult Veterans.

Journal of geriatric psychiatry and neurology

Noland MDW, Paolillo EW, Noda A, Lazzeroni LC, Holty JC, Kuschner WG, Yesavage J, Kinoshita LM

Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers.

JAMA neurology

Casaletto KB, Kornack J, Paolillo EW, Rojas JC, VandeBunte A, Staffaroni AS, Lee S, Heuer H, Forsberg L, Ramos EM, Miller BL, Kramer JH, Yaffe K, Petrucelli L, Boxer A, Boeve B, Gendron TF, Rosen H, ALLFTD Consortium

Sex Differences in the Relationship between Perceived Stress and Cognitive Trajectories.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Paolillo EW, You M, Gontrum E, Saloner R, Gaynor LS, Kramer JH, Casaletto KB

Combined Effects of Synaptic and Axonal Integrity on Longitudinal Gray Matter Atrophy in Cognitively Unimpaired Adults.

Neurology

Saloner R, Fonseca C, Paolillo EW, Asken BM, Djukic NA, Lee S, Nilsson J, Brinkmalm A, Blennow K, Zetterberg H, Kramer JH, Casaletto KB

Cognitive and Physiologic Reserve Independently Relate to Superior Neurocognitive Abilities in Adults Aging With HIV.

Journal of acquired immune deficiency syndromes (1999)

Saloner R, Lobo JD, Paolillo EW, Campbell LM, Letendre SL, Cherner M, Grant I, Heaton RK, Ellis RJ, Moore DJ, CHARTER Study Group

Initial Psychometric Properties of 7 NeuroUX Remote Ecological Momentary Cognitive Tests Among People With Bipolar Disorder: Validation Study.

Journal of medical Internet research

Moore RC, Parrish EM, Van Patten R, Paolillo E, Filip TF, Bomyea J, Lomas D, Twamley EW, Eyler LT, Depp CA

Wearable Use in an Observational Study Among Older Adults: Adherence, Feasibility, and Effects of Clinicodemographic Factors.

Frontiers in digital health

Paolillo EW, Lee SY, VandeBunte A, Djukic N, Fonseca C, Kramer JH, Casaletto KB

Higher Comorbidity Burden Predicts Worsening Neurocognitive Trajectories in People with Human Immunodeficiency Virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Ellis RJ, Paolillo E, Saloner R, Heaton RK

Social Contact Frequency and Pain among Older Adults with HIV: An Ecological Momentary Assessment Study.

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

Herbert MS, Wooldridge JS, Paolillo EW, Depp CA, Moore RC

Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.

AIDS and behavior

Saloner R, Lobo JD, Paolillo EW, Campbell LM, Letendre SL, Cherner M, Grant I, Heaton RK, Ellis RJ, Roesch SC, Moore DJ, CHARTER Study Group

Relationships between daily mood states and real-time cognitive performance in individuals with bipolar disorder and healthy comparators: A remote ambulatory assessment study.

Journal of clinical and experimental neuropsychology

Bomyea JA, Parrish EM, Paolillo EW, Filip TF, Eyler LT, Depp CA, Moore RC

Use of digital health technologies to examine subjective and objective sleep with next-day cognition and daily indicators of health in persons with and without HIV.

Journal of behavioral medicine

Sun-Suslow N, Campbell LM, Tang B, Fisher AC, Lee E, Paolillo EW, Heaton A, Moore RC

Binge Drinking Relates to Worse Neurocognitive Functioning Among Adults Aging with HIV.

Journal of the International Neuropsychological Society : JINS

Paolillo EW, Saloner R, Kohli M, Watson CW, Moore RC, Heaton RK, Moore DJ

Chronically elevated depressive symptoms interact with acute increases in inflammation to predict worse neurocognition among people with HIV.

Journal of neurovirology

Saloner R, Paolillo EW, Heaton RK, Grelotti DJ, Stein MB, Miller AH, Atkinson JH, Letendre SL, Ellis RJ, Grant I, Iudicello JE, Moore DJ

Increased Social Interactions Reduce the Association Between Constricted Life-Space and Lower Daily Happiness in Older Adults With and Without HIV: A GPS and Ecological Momentary Assessment Study.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Kamalyan L, Yang JA, Pope CN, Paolillo EW, Campbell LM, Tang B, Marquine MJ, Depp CA, Moore RC

Validation of the mobile verbal learning test: Illustration of its use for age and disease-related cognitive deficits.

International journal of methods in psychiatric research

Moore RC, Paolillo EW, Sundermann EE, Campbell LM, Delgadillo J, Heaton A, Swendsen J, Depp CA

Daily Activities Related to Mobile Cognitive Performance in Middle-Aged and Older Adults: An Ecological Momentary Cognitive Assessment Study.

JMIR mHealth and uHealth

Campbell LM, Paolillo EW, Heaton A, Tang B, Depp CA, Granholm E, Heaton RK, Swendsen J, Moore DJ, Moore RC

Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease.

Brain, behavior, and immunity

Saloner R, Cherner M, Grelotti DJ, Paolillo EW, Moore DJ, Heaton RK, Letendre SL, Kumar A, Grant I, Ellis RJ

Brief Report: Frailty and HIV Disease Severity Synergistically Increase Risk of HIV-Associated Neurocognitive Disorders.

Journal of acquired immune deficiency syndromes (1999)

Sun-Suslow N, Paolillo EW, Morgan EE, Letendre S, Iudicello J, Moore DJ

Cumulative Burden of Depression and Neurocognitive Decline Among Persons With HIV: A Longitudinal Study.

Journal of acquired immune deficiency syndromes (1999)

Paolillo EW, Pasipanodya EC, Moore RC, Pence BW, Atkinson JH, Grelotti DJ, Grant I, Heaton RK, Moore DJ

Informing Informed Consent for HIV Research.

Journal of empirical research on human research ethics : JERHRE

Campbell LM, Paolillo EW, Bryan R, Marquie-Beck J, Moore DJ, Nebeker C, Moore RC

The Effects of Low-Risk Drinking on Neurocognition Among Older Persons Living With HIV as Compared to Those Without HIV.

Alcoholism, clinical and experimental research

Kohli M, Paolillo EW, Saloner R, Umlauf A, Ellis R, Moore DJ

Smartphone-Based Measurement of Executive Function in Older Adults with and without HIV.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Moore RC, Campbell LM, Delgadillo JD, Paolillo EW, Sundermann EE, Holden J, Schweitzer P, Heaton RK, Swendsen J

Cannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV.

Journal of acquired immune deficiency syndromes (1999)

Watson CW, Paolillo EW, Morgan EE, Umlauf A, Sundermann EE, Ellis RJ, Letendre S, Marcotte TD, Heaton RK, Grant I

Pre-frailty predicts cognitive decline at 2-year follow-up in persons living with HIV.

Journal of neurovirology

Paolillo EW, Sun-Suslow N, Pasipanodya EC, Morgan EE, Ellis RJ, Jeste DV, Moore DJ

Frailty in Comorbid HIV and Lifetime Methamphetamine Use Disorder: Associations with Neurocognitive and Everyday Functioning.

AIDS research and human retroviruses

Paolillo EW, Saloner R, Montoya JL, Campbell LM, Pasipanodya EC, Iudicello JE, Moore RC, Letendre SL, Jeste DV, Moore DJ

Conditional Effects of Lifetime Alcohol Consumption on Methamphetamine-Associated Neurocognitive Performance.

Journal of the International Neuropsychological Society : JINS

Saloner R, Paolillo EW, Umlauf A, Moore DJ, Heaton RK, Grant I, Cherner M, TMARC Group

Neurocognitive SuperAging in Older Adults Living With HIV: Demographic, Neuromedical and Everyday Functioning Correlates.

Journal of the International Neuropsychological Society : JINS

Saloner R, Campbell LM, Serrano V, Montoya JL, Pasipanodya E, Paolillo EW, Franklin D, Ellis RJ, Letendre SL, Collier AC, Clifford DB, Gelman BB, Marra CM, McCutchan JA, Morgello S, Sacktor N, Jeste DV, Grant I, Heaton RK, Moore DJ, CHARTER and HNRP Groups

Depression and aging with HIV: Associations with health-related quality of life and positive psychological factors.

Journal of affective disorders

Rooney AS, Moore RC, Paolillo EW, Gouaux B, Umlauf A, Letendre SL, Jeste DV, Moore DJ, HIV Neurobehavioral Research Program

Age of Last Alcohol Use Disorder Relates to Processing Speed Among Older Adults Living with HIV.

Alcohol and alcoholism (Oxford, Oxfordshire)

Paolillo EW, Inkelis SM, Heaton A, Saloner R, Moore RC, Moore DJ

Inflammation Relates to Poorer Complex Motor Performance Among Adults Living With HIV on Suppressive Antiretroviral Therapy.

Journal of acquired immune deficiency syndromes (1999)

Montoya JL, Campbell LM, Paolillo EW, Ellis RJ, Letendre SL, Jeste DV, Moore DJ

Sex differences in HIV-associated cognitive impairment.

AIDS (London, England)

Sundermann EE, Heaton RK, Pasipanodya E, Moore RC, Paolillo EW, Rubin LH, Ellis R, Moore DJ, HNRP Group

Neurocognitive functioning predicts frailty index in HIV.

Neurology

Oppenheim H, Paolillo EW, Moore RC, Ellis RJ, Letendre SL, Jeste DV, Grant I, Moore DJ, HIV Neurobehavioral Research Program (HNRP)

Temporal Associations Between Social Activity and Mood, Fatigue, and Pain in Older Adults With HIV: An Ecological Momentary Assessment Study.

JMIR mental health

Paolillo EW, Tang B, Depp CA, Rooney AS, Vaida F, Kaufmann CN, Mausbach BT, Moore DJ, Moore RC

NIH Toolbox® Emotion Batteries for Children: Factor-Based Composites and Norms.

Assessment

Paolillo EW, McKenna BS, Nowinski CJ, Thomas ML, Malcarne VL, Heaton RK

Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection.

Addictive behaviors

Paolillo EW, Obermeit LC, Tang B, Depp CA, Vaida F, Moore DJ, Moore RC

At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS.

Alcoholism, clinical and experimental research

Paolillo EW, Gongvatana A, Umlauf A, Letendre SL, Moore DJ

Stability in Test-Usage Practices of Clinical Neuropsychologists in the United States and Canada Over a 10-Year Period: A Follow-Up Survey of INS and NAN Members.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Rabin LA, Paolillo E, Barr WB

Human cystic echinococcosis in a Uruguayan community: a sonographic, serologic, and epidemiologic study.

The American journal of tropical medicine and hygiene

Cohen H, Paolillo E, Bonifacino R, Botta B, Parada L, Cabrera P, Snowden K, Gasser R, Tessier R, Dibarboure L, Wen H, Allan JC, Soto de Alfaro H, Rogan MT, Craig PS