Kamalini Ranasinghe, MBBS, PhD

Assistant Professor
[email protected]
+1 415 514-8847

Dr. Kamalini Ranasinghe received her medical degree from the University of Peradeniya, Sri Lanka and completed her internship training in general medicine and general surgery. She earned her doctorate degree in Cognition and Neuroscience from the University of Texas at Dallas, under the mentorship of Dr. Michael Kilgard.

Dr. Ranasinghe is an assistant professor at the Memory and Aging Center. Her research centers on the network dysfunction of neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration. Much of her work has been devoted to identifying the spatial and temporal characteristics network dysfunction using MEG-imaging of the brain.

Publications: 

Abnormal gamma phase-amplitude coupling in the parahippocampal cortex is associated with network hyperexcitability in Alzheimer’s disease.

Brain Communications

Pooja Prabhu, Hirofumi Morise, Kiwamu Kudo, Alexander Beagle, Danielle Mizuiri, Faatimah Syed, Karunakar A Kotegar, Anne Findlay, Bruce L Miller, Joel H Kramer, Katherine P Rankin, Paul A Garcia, Heidi E Kirsch, Keith Vossel, Srikantan S Nagarajan, Kamalini G Ranasinghe

Neurophysiological trajectories in Alzheimer’s disease progression.

eLife

Kiwamu Kudo, Kamalini G Ranasinghe, Hirofumi Morise, Faatimah Syed, Kensuke Sekihara, Katherine P Rankin, Bruce L Miller, Joel H Kramer, Gil D Rabinovici, Keith Vossel, Heidi E Kirsch, Srikantan S Nagarajan

Neuronal hyperexcitability in AD.

Alzheimer's & Dementia

Kamalini G Ranasinghe

Neurophysiological changes associated with plasma p-tau represent functional effects of amyloid accumulation and are modulated by APOE.

Alzheimer's & Dementia

Kamalini G Ranasinghe, Julio C. Rojas, Kaitlin B. Casaletto, Kiwamu Kudo, Faatimah Syed, Renaud La Joie, Brandon Chan, Argentina Lario Lago, Bruce L Miller, Keith Vossel, Joel H. Kramer, Adam L. Boxer, Katherine P Rankin, Gil D. Rabinovici, Srikantan S Nagarajan

Quantitative Amyloid-PET in Real-World Practice: Lessons from the Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study.

Alzheimer's & Dementia

Renaud La Joie, Nidhi S. Mundada, Ganna Blazhenets, Jhony Alejandro Mejía-Perez, Daniel R Schonhaut, Ehud Zeltzer, David N. Soleimani-Meigooni, Hanna Cho, Kamalini G Ranasinghe, Charles Windon, Golnaz Yadollahikhales, Leonardo Iaccarino, Robert Koeppe, Maria C. Carrillo, Lucy Hanna, Constantine Gatsonis, Andrew March, Barry A Siegel, Bruce E Hillner, Rachel A. Whitmer, Gil D. Rabinovici

Spectral graph modeling reveals global slowing of neurophysiological network transmission in Alzheimer’s disease.

Alzheimer's & Dementia

Parul Verma, Kamalini G Ranasinghe, Janani Prasad, Chang Cai, Xihe Xie, Hannah M Lerner, Danielle Mizuiri, Bruce L Miller, Katherine P Rankin, Keith Vossel, Srikantan S Nagarajan, Ashish Raj

Abnormal gamma frequency phase-amplitude coupling associated with network hyperexcitability in Alzheimer’s Disease.

Alzheimer's & Dementia

Pooja Prabhu, Kamalini G Ranasinghe, Hirofumi Morise, Kiwamu Kudo, Leighton B Hinkley, Hannah M Lerner, Danielle Mizuiri, Abigail Licata, Karunakar A Kotegar, Anne Findlay, Bruce L Miller, Marilu Gorno-Tempini, Joel H. Kramer, Katherine P Rankin, Paul Garcia, Heidi Kirsch, John F Houde, Keith Vossel, Srikantan S Nagarajan

Spectral signatures associated with cognitive aging, APOE4, amyloid-ß and measures of axonal integrity in cognitively unimpaired adults.

Alzheimer's & Dementia

Kamalini G Ranasinghe, Kaitlin B Casaletto, Kiwamu Kudo, Hannah M Lerner, Danielle Mizuiri, Renaud La Joie, Bruce L. Miller, Keith Vossel, Joel H. Kramer, William J. Jagust, Katherine P Rankin, Gil D. Rabinovici, Srikantan S Nagarajan

Sleep patterns differ across Alzheimer’s disease phenotypes: Implications for selective vulnerability and customized treatment.

Alzheimer's & Dementia

Neus Falgàs Martínez, Leslie Ruoff, Youssef M Essanaa, Michael M Le, Michelle You, Joel H Kramer, Keith A Vossel, Thomas Neylan, Christine M Walsh, Kamalini G Ranasinghe, Lea T. Grinberg

Abnormal neural oscillations depicting excitatory-inhibitory imbalance are distinctly associated with amyloid and tau depositions in Alzheimer's disease.

Alzheimer's & Dementia

Kamalini G. Ranasinghe, Parul Verma, Chang Cai, Xihe Xie, Kiwamu Kudo, Xiao Gao, Hannah M. Lerner, Danielle Mizuiri, Amelia Strom, Leonardo Iaccarino, Renaud La Joie, Bruce L. Miller, Maria Luisa Gorno Tempini, Katherine P. Rankin, William J. Jagust, Keith A. Vossel, Gil D. Rabinovici, Ashish Raj, Srikantan S. Nagarajan

073 Whole-brain network analysis of neural oscillations during light sleep.

Sleep

Joline Fan, Kiwamu Kudo, Kamalini Ranasinghe, Hirofumi Morise, Anne Findlay, Heidi Kirsch, Andrew Krystal, Srikantan Nagarajan

Alpha-frequency synchronization deficits during life predict postmortem neurofibrillary tangle burden in Alzheimer’s disease.

Alzheimer's & Dementia

Kamalini G Ranasinghe, Cathrine Petersen, Kiwamu Kudo, Srivatsan Srivatsan, Alexander J Beagle, Danielle Mizuiri, Anne Findlay, John F Houde, Katherine Rankin, Gil D Rabinovici, William W. Seeley, Salvatore Spina, Marilu Gorno-Tempini, Joel H Kramer, Bruce L Miller, Keith A Vossel, Lea Tenenholz Grinberg, Srikantan S Nagarajan

Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-ß accumulation, and cognitive decline.

Science translational medicine

Ranasinghe KG, Cha J, Iaccarino L, Hinkley LB, Beagle AJ, Pham J, Jagust WJ, Miller BL, Rankin KP, Rabinovici GD, Vossel KA, Nagarajan SS

NEURAL ACTIVITY PATTERNS UNDERLYING ABNORMAL PHONOLOGICAL PROCESSING IN PATIENTS WITH LOGOPENIC VARIANT PRIMARY PROGRESSIVE APHASIA.

Alzheimer's & Dementia

Kamalini G. Ranasinghe, Alexander J. Beagle, Danielle Mizuiri, Susanne Honma, Ariane E. Welch, Maria Luisa Gorno Tempini, Keith A. Vossel, John F. Houde, Srikantan S. Nagarajan

Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.

Scientific reports

Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS

DISTINCT NEURAL OSCILLATION ABNORMALITIES ASSOCIATED WITH AMYLOID-BETA AND TAU IN ALZHEIMER’S DISEASE.

Alzheimer's & Dementia

Kamalini G. Ranasinghe, Jungho Cha, Leighton B. Hinkley, Alexander J. Beagle, Danielle Mizuiri, Susanne Honma, Viktoriya Bourakova, William J. Jagust, Bruce L. Miller, Gil D. Rabinovici, Srikantan S. Nagarajan, Keith A. Vossel

Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease.

Neurobiology of aging

Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Nagarajan SS, Houde JF

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.

JAMA neurology

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL

Clinical Characteristics of bvFTD Across CDR Stages (P3.201).

Neurology

Kamalini Ranasinghe, Peter Pressman, David Perry, Katherine Rankin, Bruce Miller

Region Specific Alpha-Band Resting-State Functional Connectivity Predicts Focal Cognitive Deficits In Alzheimer’s Disease Spectrum (P6.318).

Neurology

Kamalini Ranasinghe, Leighton Hinkley, Alexander Beagle, Danielle Mizuiri, Anne Dowling, Susanne Honma, Mariel Finucane, Carole Scherling, Bruce Miller, Srikatan Nagarajan, Keith Vossel

Neural mechanisms supporting robust discrimination of spectrally and temporally degraded speech.

Journal of the Association for Research in Otolaryngology : JARO

Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP

Speech discrimination after early exposure to pulsed-noise or speech.

Hearing research

Ranasinghe KG, Carraway RS, Borland MS, Moreno NA, Hanacik EA, Miller RS, Kilgard MP

Weight loss via diet and exercise improves exercise breathing mechanics in obese men.

Chest

Babb TG, Wyrick BL, Chase PJ, DeLorey DS, Rodder SG, Feng MY, Ranasinghe KG

Discrimination of brief speech sounds is impaired in rats with auditory cortex lesions.

Behavioural brain research

Porter BA, Rosenthal TR, Ranasinghe KG, Kilgard MP

Dyspnea on exertion in obese women: association with an increased oxygen cost of breathing.

American journal of respiratory and critical care medicine

Babb TG, Ranasinghe KG, Comeau LA, Semon TL, Schwartz B

Short-term modulation of the exercise ventilatory response is not diminished in older men.

The FASEB Journal

Helen E. Wood, C J Rowell, C D Storms, M N Klocko, K Ranasinghe, G S Mitchell, T G Babb

Short-term modulation of the exercise ventilatory response in humans.

The FASEB Journal

H E Wood, M N Klocko, K G Ranasinghe, G S Mitchell, T G Babb

The exercise ventilatory response does not differ between obese women with and without dyspnea on exertion.

The FASEB Journal

H E Wood, T L Semon, L A Comeau, B Schwartz, R M MacDougall, M N Klocko, K G Ranasinghe, T G Babb