Paul Sampognaro, MD

HS Asst Clinical Professor

+1 415 353-2122

Fields of Interest:

Dr. Sampognaro majored in neurobiology as an undergrad at Georgetown University. There, he worked as a research assistant in the laboratory of Maria Donoghue, studying the molecular underpinnings of Eph/ephrin signaling and its role in cortical neuronal development. After college, he matriculated to the Johns Hopkins University School of Medicine, where he earned his MD and worked part-time in Charlotte Sumner’s laboratory, quantifying the degree of SMN1 insufficiency in humans with spinal muscular atrophy. As a fourth-year neurology resident at UCSF, Paul joined the Kao Lab for his Flexible Residency. Here, he has focused on TDP-43 mutations and their potential impact on lysosomal function in ALS motor neurons.

Publications:

Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.

Brain : a journal of neurology

Babu S, Nicholson KA, Rothstein JD, Swenson A, Sampognaro PJ, Pant P, Macklin EA, Spruill S, Paganoni S, Gendron TF, Prudencio M, Petrucelli L, Nix D, Landrette S, Nkrumah E, Fandrick K, Edwards J, Young PR

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Molecular neurodegeneration

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW

Mutations in a-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Molecular neurodegeneration

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

Molecular neurodegeneration

Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.

Frontiers in neuroscience

Gururaj S, Sampognaro PJ, Argouarch AR, Kao AW

Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention.

Acta neuropathologica

Sloan EA, Sampognaro PJ, Junn JC, Chin C, Jacques L, Ramachandran PS, DeRisi JL, Wilson MR, Kriegstein AR, Bollen AW, Solomon DA, Margeta M, Engstrom JW

C9orf72-specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregation.

Acta neuropathologica

Sampognaro PJ, Vatsavayai SC, Cosme CG, Hwang JL, Nolan A, Huang EJ, Seeley WW, De May MG

Acute Sensorimotor Deficit as a Lone Manifestation of Neurocysticercosis: An Important Differential Diagnosis in Emergency Departments of Developed Countries.

Journal of global infectious diseases

Deng H, Yue JK, Sampognaro PJ, Rosendale N

Paul Sampognaro, MD

Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Mutations in a-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.

Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention.

C9orf72-specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregation.

Acute Sensorimotor Deficit as a Lone Manifestation of Neurocysticercosis: An Important Differential Diagnosis in Emergency Departments of Developed Countries.

Bismuth Subgallate Toxicity in the Age of Online Supplement Use.

EphA7 signaling guides cortical dendritic development and spine maturation.

Medical student appraisal: electronic resources for inpatient pre-rounding.

Medical student appraisal: applications for bedside patient education.

Survival and recurrence for patients undergoing surgery of skull base intracranial metastases.

Medical student appraisal: searching on smartphones.

Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice.

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Paul Sampognaro, MD