Courtney Lane-Donovan, MD, PhD

Assistant Professor
+1 415 353-2273

Courtney studied biological engineering and biology at the Massachusetts Institute of Technology. She then completed her MD/PhD at UT Southwestern. She trained with Dr. Joachim Herz studying ApoE receptor signaling in transgenic mouse models of Alzheimer's disease. She identified a role for reelin, a protein that is vital for brain development, in protecting older rodents against amyloid beta, one of the primary pathology proteins that accumulate in Alzheimer's disease. As a fourth-year neurology resident at the University of California, San Francisco, and then continuing as an R25 postdoctoral researcher, Courtney will be studying lysosomal health and function in models of aging.


Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.


Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J

Building a better blood-brain barrier.


Lane-Donovan C, Herz J

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

Trends in endocrinology and metabolism: TEM

Lane-Donovan C, Herz J

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J

Physiologic Reelin does not play a strong role in protection against acute stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Lane-Donovan C, Desai C, Pohlkamp T, Plautz EJ, Herz J, Stowe AM

Reelin protects against amyloid ß toxicity in vivo.

Science signaling

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J

Science Signaling Podcast: 7 July 2015.

Science signaling

Courtney Lane-Donovan, Joachim Herz, Annalisa M. VanHook

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.

PloS one

Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.

Science signaling

Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J