Courtney Lane-Donovan, MD, PhD

Assistant Professor

+1 415 353-2273

Courtney studied biological engineering and biology at the Massachusetts Institute of Technology. She then completed her MD/PhD at UT Southwestern. She trained with Dr. Joachim Herz studying ApoE receptor signaling in transgenic mouse models of Alzheimer's disease. She identified a role for reelin, a protein that is vital for brain development, in protecting older rodents against amyloid beta, one of the primary pathology proteins that accumulate in Alzheimer's disease. As a fourth-year neurology resident at the University of California, San Francisco, and then continuing as an R25 postdoctoral researcher, Courtney will be studying lysosomal health and function in models of aging.

Publications:

Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.

Neurology

Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD

Disentangling tau: One protein, many therapeutic approaches.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Lane-Donovan C, Boxer AL

Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.

The Journal of clinical investigation

Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL

Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature.

Open forum infectious diseases

Lane-Donovan C, Bainbridge E, Szumowski J, Kerkhoff AD, Peluso MJ

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.

eLife

Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J

Building a better blood-brain barrier.

eLife

Lane-Donovan C, Herz J

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.

Journal of lipid research

Lane-Donovan C, Herz J

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

Trends in endocrinology and metabolism: TEM

Lane-Donovan C, Herz J

NGP 555, a ?-Secretase Modulator, Lowers the Amyloid Biomarker, Aß42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.

Alzheimer's & dementia (New York, N. Y.)

Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J

Physiologic Reelin does not play a strong role in protection against acute stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Lane-Donovan C, Desai C, Pohlkamp T, Plautz EJ, Herz J, Stowe AM

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.

PloS one

Lane-Donovan C, Herz J

Reelin protects against amyloid ß toxicity in vivo.

Science signaling

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J