Ethan Geier, PhD

Postdoctoral Fellow

+1 415 476-8101

Fields of Interest:

Ethan is a postdoctoral scholar at the Memory and Aging Center interested in understanding how genetic variation contributes to the development of neurodegenerative disease. He graduated from the University of California, Berkeley with a bachelor’s degree in molecular and cell biology and earned a PhD degree in 2013 from the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco in the laboratory of Dr. Kathleen M. Giacomini. His dissertation work focused on characterizing how membrane transporter proteins influence drug penetration across the blood-brain barrier. After graduate school, Ethan co-founded Apricity Therapeutics with Dr. Giacomini to create safer, more effective therapies for pediatric diseases using technology he helped develop during his dissertation work. Ethan loves traveling and BBQing with family and friends in his free time.

Publications:

Genetic pleiotropy and the shared pathological features of corticobasal degeneration and progressive supranuclear palsy: a case report and a review of the literature.

Neurocase

Rini J, Asken B, Geier E, Rankin K, Kramer J, Boxer A, Miller B, Yokoyama J, Spina S

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.

Nature communications

Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.

American journal of human genetics

Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS

Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.

Cold Spring Harbor molecular case studies

Cochran JN, McKinley EC, Cochran M, Amaral MD, Moyers BA, Lasseigne BN, Gray DE, Lawlor JMJ, Prokop JW, Geier EG, Holt JM, Thompson ML, Newberry JS, Yokoyama JS, Worthey EA, Geldmacher DS, Love MN, Cooper GM, Myers RM, Roberson ED

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.

Scientific reports

Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, Yokoyama JS

LOSS-OF-FUNCTION CODING AND NON-CODING VARIANTS IN TET2 ARE ASSOCIATED WITH NEURODEGENERATIVE DISEASES.

Alzheimer's & Dementia

J. Nicholas Cochran, Ethan G. Geier, Juliana Acosta-Uribe, Michelle L. Thompson, Michelle D. Amaral, J. Scott Newberry, James M.J. Lawlor, Brittany N. Lasseigne, Meagan E. Cochran, Luke W. Bonham, Anna M. Karydas, Erik D. Roberson, Francisco Lopera, Kenneth S. Kosik, Gregory M. Cooper, Gil D. Rabinovici, Bruce L. Miller, Richard M. Myers, Jennifer S. Yokoyama

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Acta neuropathologica

Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R

Recent advances in the genetics of frontotemporal dementia.

Current genetic medicine reports

Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.

Acta neuropathologica

Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS

Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.

Neurology. Genetics

Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS

Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer's Disease.

Frontiers in neuroscience

Carr JS, Bonham LW, Morgans AK, Ryan CJ, Yokoyama JS, Geier EG

Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice.

Frontiers in neuroscience

Bonham LW, Geier EG, Steele NZR, Holland D, Miller BL, Dale AM, Desikan RS, Yokoyama JS

ASSOCIATION OF ALZHEIMER’S DISEASE WITH ANDROGEN RECEPTOR VARIANTS AND PLASMA TESTOSTERONE LEVELS IMPLICATES DECREASED TESTOSTERONE SIGNALING IN NEURODEGENERATION.

Alzheimer's & Dementia

Jessie S. Carr, Luke W. Bonham, Charles J. Ryan, Jennifer S. Yokoyama, Ethan G. Geier, Alzheimer's Disease Neuroimaging Initiative

STOP-GAIN VARIANT IN MICROGLIA-EXPRESSED GENE GMIP IS ASSOCIATED WITH EARLY-ONSET ALZHEIMER’S DISEASE.

Alzheimer's & Dementia

Raiyan R. Khan, Andre Altmann, Valerio Napolioni, Yongha Kim, Rita Guerreiro, Jose T. Bras, Susana Carmona, Miguel Pereira, Isabel Santana, John Hardy, Simon Mead, Carlos Cruchaga, Maria Victoria Fernandez, Henne Holstege, Wiesje M. Van der Flier, Marc Hulsman, Sven J. Van der Lee, Yuning Chen, Joshua C. Bis, Lenore J. Launer, Cornelia M. van Duijn, Adam C. Naj, Gerard D. Schellenberg, Giovanni Coppola, Jason A. Chen, Sudha Seshadri, J. Nicholas Cochran, Richard Myers, Ethan G. Geier, Jennifer S. Yokoyama, Gil D. Rabinovici, Bruce L. Miller, Joel H. Kramer, Anna M. Karydas, Keeley J. Brookes, Tamar Guetta-Baranes, James Turton, Raja Chaudhury, Kevin Morgan, Summer Han, Michael D. Greicius, and CHARGE ADGC

CXCR4 involvement in neurodegenerative diseases.

Translational psychiatry

Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS

FINE-MAPPING OF THE HUMAN LEUKOCYTE ANTIGEN (HLA) LOCUS AS A RISK FACTOR FOR ALZHEIMER'S DISEASE.

Alzheimer's & Dementia

Jessie S. Carr,Natasha ZR. Steele,Luke W. Bonham,Ethan G. Geier,Vincent Damotte,Zachary A. Miller,Rahul S. Desikan,Kevin L. Boehme,Shubhabrata Mukherjee,Paul K. Crane,John Kauwe,Joel H. Kramer,Bruce L. Miller,Giovanni Coppola,Jill A. Hollenbach,Yadong Huang,Jennifer S. Yokoyama, ADNI

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.

PLoS medicine

Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Suhy AM, Webb A, Papp AC, Geier EG, Sadee W

Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.

Acta neuropathologica communications

Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS

Age-dependent effects of APOE e4 in preclinical Alzheimer's disease.

Annals of clinical and translational neurology

Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.

Molecular pharmacology

Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM

Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.

Drug metabolism and disposition: the biological fate of chemicals

Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N

Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses.

Biochemistry

Oda MN, Budamagunta MS, Geier EG, Chandradas SH, Shao B, Heinecke JW, Voss JC, Cavigiolio G

Profiling solute carrier transporters in the human blood-brain barrier.

Clinical pharmacology and therapeutics

Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.

Proceedings of the National Academy of Sciences of the United States of America

Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM

Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Molecular pharmaceutics

Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.

International journal of molecular imaging

Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK