Jesse Brown, PhD

Assistant Professor
+1 415 502-7187
Fields of Interest: 

Dr. Jesse Brown is an assistant professor and works closely with the Seeley Selective Vulnerability Research Lab. His research is focused on:

  1. unraveling functional and anatomical brain connectivity
  2. diagnosing, tracking and ultimately curing neurodegenerative disease
  3. advancing neuroimaging data sharing and visualization
Publications: 

State and trait characteristics of anterior insula time-varying functional connectivity.

NeuroImage

Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial.

JAMA neurology

Tsai RM, Miller Z, Koestler M, Rojas JC, Ljubenkov PA, Rosen HJ, Rabinovici GD, Fagan AM, Cobigo Y, Brown JA, Jung JI, Hare E, Geldmacher DS, Natelson-Love M, McKinley EC, Luong PN, Chuu EL, Powers R, Mumford P, Wolf A, Wang P, Shamloo M, Miller BL, Roberson ED, Boxer AL

State-based network similarity visualization.

Information Visualization

Sugeerth Murugesan, Kristofer Bouchard, Jesse Brown, Mariam Kiran, Dan Lurie, Bernd Hamann, Gunther H Weber

Evidence of corticofugal tau spreading in patients with frontotemporal dementia.

Acta neuropathologica

Kim EJ, Hwang JL, Gaus SE, Nana AL, Deng J, Brown JA, Spina S, Lee MJ, Ramos EM, Grinberg LT, Kramer JH, Boxer AL, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW

Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy.

Neuron

Brown JA, Deng J, Neuhaus J, Sible IJ, Sias AC, Lee SE, Kornak J, Marx GA, Karydas AM, Spina S, Grinberg LT, Coppola G, Geschwind DH, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW

HEMISPHERIC ASYMMETRY IN NEURODEGENERATIVE DISEASES.

Alzheimer's & Dementia

Eun-Joo Kim, Jersey Deng, Jesse Brown, Salvatore Spina, Bruce L. Miller, William W. Seeley

Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.

Brain : a journal of neurology

Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.

NeuroImage. Clinical

Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD

Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease.

NeuroImage. Clinical

Kim JP, Kim J, Park YH, Park SB, Lee JS, Yoo S, Kim EJ, Kim HJ, Na DL, Brown JA, Lockhart SN, Seo SW, Seong JK

Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.

NeuroImage. Clinical

Lee SE, Sias AC, Kosik EL, Flagan TM, Deng J, Chu SA, Brown JA, Vidovszky AA, Ramos EM, Gorno-Tempini ML, Karydas AM, Coppola G, Geschwind DH, Rademakers R, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Seeley WW

Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.

NeuroImage. Clinical

Toller G, Yang WFZ, Brown JA, Ranasinghe KG, Shdo SM, Kramer JH, Seeley WW, Miller BL, Rankin KP

Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?

NeuroImage. Clinical

Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW

Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series.

Journal of neurology

Kim EJ, Brown JA, Deng J, Hwang JL, Spina S, Miller ZA, DeMay MG, Valcour V, Karydas A, Ramos EM, Coppola G, Miller BL, Rosen HJ, Seeley WW, Grinberg LT

Network architecture underlying basal autonomic outflow: Evidence from frontotemporal dementia.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sturm VE, Brown JA, Hua AY, Lwi SJ, Zhou J, Kurth F, Eickhoff SB, Rosen HJ, Kramer JH, Miller BL, Levenson RW, Seeley WW

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML

Early affective changes and increased connectivity in preclinical Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW

PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMER’S DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED SPREAD.

Alzheimer's & Dementia

Jesse Brown, Renaud La Joie, Adrienne Visani, Howard J. Rosen, Bruce L. Miller, William J. Jagust, William W. Seeley, Gil D. Rabinovici

PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMER’S DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED SPREAD.

Alzheimer's & Dementia

Jesse Brown, Renaud La Joie, Adrienne Visani, Howard J. Rosen, Bruce L. Miller, William J. Jagust, William W. Seeley, Gil D. Rabinovici

Individual differences in socioemotional sensitivity are an index of salience network function.

Cortex; a journal devoted to the study of the nervous system and behavior

Toller G, Brown J, Sollberger M, Shdo SM, Bouvet L, Sukhanov P, Seeley WW, Miller BL, Rankin KP

Minimum spanning tree analysis of the human connectome.

Human brain mapping

van Dellen E, Sommer IE, Bohlken MM, Tewarie P, Draaisma L, Zalesky A, Di Biase M, Brown JA, Douw L, Otte WM, Mandl RCW, Stam CJ

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Advancing functional dysconnectivity and atrophy in progressive supranuclear palsy.

NeuroImage. Clinical

Brown JA, Hua AY, Trujllo A, Attygalle S, Binney RJ, Spina S, Lee SE, Kramer JH, Miller BL, Rosen HJ, Boxer AL, Seeley WW

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.

Alzheimer's & dementia (New York, N. Y.)

Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL

INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?.

Alzheimer's & Dementia

Carolyn A. Fredericks, Jesse Brown, Jersey Deng, Rik Ossenkoppele, Katherine Rankin, Joel H. Kramer, Bruce L. Miller, Gil D. Rabinovici, William W. Seeley

INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?.

Alzheimer's & Dementia

Carolyn A. Fredericks, Jesse Brown, Jersey Deng, Rik Ossenkoppele, Katherine Rankin, Joel H. Kramer, Bruce L. Miller, Gil D. Rabinovici, William W. Seeley

Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.

Brain imaging and behavior

Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers.

NeuroImage. Clinical

Lee SE, Sias AC, Mandelli ML, Brown JA, Brown AB, Khazenzon AM, Vidovszky AA, Zanto TP, Karydas AM, Pribadi M, Dokuru D, Coppola G, Geschwind DH, Rademakers R, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW

Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia.

Brain : a journal of neurology

Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, Santos-Santos MA, Miller ZA, Pakvasa M, Henry ML, Rosen HJ, Henry RG, Rabinovici GD, Miller BL, Seeley WW, Gorno-Tempini ML

Progressive Supranuclear Palsy and Related Parkinsonian Disorders

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Jesse A. Brown, William W. Seeley

TAU COVARIANCE PATTERNS IN AD PATIENTS RESEMBLE INTRINSIC CONNECTIVITY NETWORKS IN YOUNG ADULTS.

Alzheimer's & Dementia

Rik Ossenkoppele, Daniel R. Schonhaut, Jesse Brown, James P. O'Neil, Mustafa Janabi, Suzanne L. Baker, Michael Schöll, Joel Kramer, Marie-Luisa Gorno Tempini, Bruce Miller, William W. Seeley, William J. Jagust, Gil D. Rabinovici

TAU COVARIANCE PATTERNS IN ALZHEIMER'S DISEASE PATIENTS RESEMBLE INTRINSIC CONNECTIVITY NETWORKS IN YOUNG ADULTS.

Alzheimer's & Dementia

Rik Ossenkoppele, Daniel R. Schonhaut, Jesse Brown, James P. O'Neil, Mustafa Janabi, Suzanne L. Baker, Michael Schöll, Joel Kramer, Marie-Luisa Gorno Tempini, Bruce Miller, William W. Seeley, William J. Jagust, Gil D. Rabinovici

Brain Modulyzer: Interactive Visual Analysis of Functional Brain Connectivity.

IEEE/ACM transactions on computational biology and bioinformatics

Murugesan S, Bouchard K, Brown JA, Hamann B, Seeley WW, Trujillo A, Weber GH

Chapter 18 Progressive Supranuclear Palsy and Related Parkinsonian Disorders.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Jesse A. Brown, William W. Seeley

Disconnection and hyper-connectivity underlie reorganization after TBI: A rodent functional connectomic analysis.

Experimental neurology

Harris NG, Verley DR, Gutman BA, Thompson PM, Yeh HJ, Brown JA

Brain connectivity and prediction of relapse after cognitive-behavioral therapy in obsessive-compulsive disorder.

Frontiers in psychiatry

Feusner JD, Moody T, Lai TM, Sheen C, Khalsa S, Brown J, Levitt J, Alger J, O'Neill J

Intrinsic functional brain architecture derived from graph theoretical analysis in the human fetus.

PloS one

Thomason ME, Brown JA, Dassanayake MT, Shastri R, Marusak HA, Hernandez-Andrade E, Yeo L, Mody S, Berman S, Hassan SS, Romero R

Non-negative matrix factorization of multimodal MRI, fMRI and phenotypic data reveals differential changes in default mode subnetworks in ADHD.

NeuroImage

Anderson A, Douglas PK, Kerr WT, Haynes VS, Yuille AL, Xie J, Wu YN, Brown JA, Cohen MS

Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints.

Evidence-based complementary and alternative medicine : eCAM

Bookheimer SY, Renner BA, Ekstrom A, Li Z, Henning SM, Brown JA, Jones M, Moody T, Small GW

Abnormal brain network organization in body dysmorphic disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Arienzo D, Leow A, Brown JA, Zhan L, Gadelkarim J, Hovav S, Feusner JD

The UCLA multimodal connectivity database: a web-based platform for brain connectivity matrix sharing and analysis.

Frontiers in neuroinformatics

Brown JA, Rudie JD, Bandrowski A, Van Horn JD, Bookheimer SY

Altered functional and structural brain network organization in autism.

NeuroImage. Clinical

Rudie JD, Brown JA, Beck-Pancer D, Hernandez LM, Dennis EL, Thompson PM, Bookheimer SY, Dapretto M

Autism-associated promoter variant in MET impacts functional and structural brain networks.

Neuron

Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto M

Insights into multimodal imaging classification of ADHD.

Frontiers in systems neuroscience

Colby JB, Rudie JD, Brown JA, Douglas PK, Cohen MS, Shehzad Z

Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Donix M, Ercoli LM, Siddarth P, Brown JA, Martin-Harris L, Burggren AC, Miller KJ, Small GW, Bookheimer SY

Brain network local interconnectivity loss in aging APOE-4 allele carriers.

Proceedings of the National Academy of Sciences of the United States of America

Brown JA, Terashima KH, Burggren AC, Ercoli LM, Miller KJ, Small GW, Bookheimer SY

Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2.

Brain connectivity

Dennis EL, Jahanshad N, Rudie JD, Brown JA, Johnson K, McMahon KL, de Zubicaray GI, Montgomery G, Martin NG, Wright MJ, Bookheimer SY, Dapretto M, Toga AW, Thompson PM

Conserved and variable architecture of human white matter connectivity.

NeuroImage

Bassett DS, Brown JA, Deshpande V, Carlson JM, Grafton ST

Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.

PLoS biology

Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA

Head module control of mediator interactions.

Molecular cell

Takagi Y, Calero G, Komori H, Brown JA, Ehrensberger AH, Hudmon A, Asturias F, Kornberg RD