Jessica de Leon, MD

Assistant Professor

Fields of Interest:

Dr. Jessica de Leon received her undergraduate degrees in neuroscience and Spanish at the Johns Hopkins University and an MD with thesis degree at UCSF. She then completed a medicine internship and neurology residency at UCSF, where she served as chief resident. She is currently an assistant professor at the UCSF Memory and Aging Center (MAC), where she focuses on care of patients with cognitive decline and dementia, including primary progressive aphasia, frontotemporal dementia and Alzheimer's dementia. She also evaluates participants through the UCSF Dyslexia Center and sees patients at the Geriatrics Neurology Center at Zuckerberg San Francisco General Hospital. Dr. de Leon is a member of the ALBA Language Neurobiology Lab. She studies how bilingualism, language background and genetics affect the symptoms of language disorders, using primary progressive aphasia (PPA) and dyslexia as models. She also has an interest in the socioeconomic factors that influence dementia care.

Publications:

Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.

Cortex; a journal devoted to the study of the nervous system and behavior

Lukic S, Fan Z, García AM, Welch AE, Ratnasiri BM, Wilson SM, Henry ML, Vonk J, Deleon J, Miller BL, Miller Z, Mandelli ML, Gorno-Tempini ML

Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.

Cortex; a journal devoted to the study of the nervous system and behavior

Gajardo-Vidal A, Montembeault M, Lorca-Puls DL, Licata AE, Bogley R, Erlhoff S, Ratnasiri B, Ezzes Z, Battistella G, Tsoy E, Pereira CW, DeLeon J, Tee BL, Henry ML, Miller ZA, Rankin KP, Mandelli ML, Possin KL, Gorno-Tempini ML

Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology.

Neurocase

Palser ER, Miller ZA, Licata AE, Yabut NA, Sudarsan SP, Tee BL, Deleon JA, Mandelli ML, Caverzasi E, Sturm VE, Hendren R, Possin KL, Miller BL, Gorno Tempini ML, Watson Pereira C

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Non-fluent/agrammatic Variant Primary Progressive Aphasia.

Neurology

García AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia.

Neurology

Garc?a AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca-Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML

Frontotemporal dementia: A unique window on the functional role of the temporal lobes.

Handbook of clinical neurology

Borghesani V, DeLeon J, Gorno-Tempini ML

Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task.

Biological Psychology

Palser ER, Morris NA, Roy ARK, Holley SR, Veziris CR, Watson C, Deleon J, Miller ZA, Miller BL, Gorno-Tempini ML, Sturm VE

Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia.

Neurocase

Tee BL, Deleon J, Chen Li Ying LK, Miller BL, Y Lo R, Europa E, Sudarsan S, Grasso S, Gorno-Tempini ML

Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Borghesani V, Wang C, Watson C, Bouhali F, Caverzasi E, Battistella G, Bogley R, Yabut NA, Deleon J, Miller ZA, Hoeft F, Mandelli ML, Gorno-Tempini ML

Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases.

Cortex; a journal devoted to the study of the nervous system and behavior

Lukic S, Borghesani V, Weis E, Welch A, Bogley R, Neuhaus J, Deleon J, Miller ZA, Kramer JH, Miller BL, Dronkers NF, Gorno-Tempini ML

Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Roy ARK, Datta S, Wang C, Sible IJ, Holley SR, Watson C, Palser ER, Morris NA, Battistella G, Rah E, Meyer M, Pakvasa M, Mandelli ML, Deleon J, Hoeft F, Caverzasi E, Miller ZA, Shapiro KA, Hendren R, Miller BL, Gorno-Tempini ML

Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.

Alzheimer's & dementia : the journal of the Alzheimer's Association

de Leon J, Grasso SM, Welch A, Miller Z, Shwe W, Rabinovici GD, Miller BL, Henry ML, Gorno-Tempini ML

Speech production differences in English and Italian speakers with nonfluent variant PPA.

Neurology

Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, Mandelli ML, Hubbard HI, Moro A, Magnani G, Cappa SF, Miller BL, Filippi M, Gorno-Tempini ML

Task-Free Functional Language Networks: Reproducibility and Clinical Application.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Mandelli ML, Gorno-Tempini ML

Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration.

Aphasiology

Vonk JMJ, Borghesani V, Battistella G, Younes K, DeLeon J, Welch A, Hubbard HI, Miller ZA, Miller BL, Gorno-Tempini ML

Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.

Neurocase

De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML

Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

NeuroImage. Clinical

Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML

Frontotemporal dementia.

Handbook of clinical neurology

Deleon J, Miller BL

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.

Brain : a journal of neurology

Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ

Jessica de Leon, MD

Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.

Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.

Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology.

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Non-fluent/agrammatic Variant Primary Progressive Aphasia.

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia.

Frontotemporal dementia: A unique window on the functional role of the temporal lobes.

Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task.

Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia.

Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.

Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases.

Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity.

Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.

Speech production differences in English and Italian speakers with nonfluent variant PPA.

Task-Free Functional Language Networks: Reproducibility and Clinical Application.

Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration.

Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.

Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Frontotemporal dementia.

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.

Elicitation of specific syntactic structures in primary progressive aphasia.

Syntactic processing depends on dorsal language tracts.

Adult glial precursor proliferation in mutant SOD1G93A mice.

Neural regions essential for distinct cognitive processes underlying picture naming.

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Jessica de Leon, MD