Jessica Deleon, MD

Assistant Professor
Fields of Interest: 

Dr. Jessica de Leon received her undergraduate degrees in neuroscience and Spanish at the Johns Hopkins University and an MD with thesis degree at UCSF. She then completed a medicine internship and neurology residency at UCSF, where she served as chief resident. She is currently an assistant professor at the UCSF Memory and Aging Center (MAC), where she focuses on care of patients with cognitive decline and dementia, including primary progressive aphasia, frontotemporal dementia and Alzheimer's dementia. She also evaluates participants through the UCSF Dyslexia Center and sees patients at the Geriatrics Neurology Center at Zuckerberg San Francisco General Hospital. Dr. de Leon is a member of the ALBA Language Neurobiology Lab. She studies how bilingualism, language background and genetics affect the symptoms of language disorders, using primary progressive aphasia (PPA) and dyslexia as models. She also has an interest in the socioeconomic factors that influence dementia care.


Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

NeuroImage. Clinical

Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML

Frontotemporal dementia.

Handbook of clinical neurology

Deleon J, Miller BL

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.

Brain : a journal of neurology

Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ

Elicitation of specific syntactic structures in primary progressive aphasia.

Brain and language

Deleon J, Gesierich B, Besbris M, Ogar J, Henry ML, Miller BL, Gorno-Tempini ML, Wilson SM

Syntactic processing depends on dorsal language tracts.


Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML, Ogar JM, DeLeon J, Miller BL, Gorno-Tempini ML

Adult glial precursor proliferation in mutant SOD1G93A mice.


Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ

Neural regions essential for distinct cognitive processes underlying picture naming.

Brain : a journal of neurology

DeLeon J, Gottesman RF, Kleinman JT, Newhart M, Davis C, Heidler-Gary J, Lee A, Hillis AE