Michael Geschwind, MD, PhD

+1 415 476-2900

Dr. Geschwind received his MD and PhD degrees in neuroscience through the National Institutes of Health (NIH)-sponsored Medical Scientist Training Program (MSTP) at the Albert Einstein College of Medicine in New York. He completed his internship in internal medicine at the University of California, Los Angeles (UCLA) Medical Center, his neurology residency at the Johns Hopkins University School of Medicine in Baltimore and his fellowship in behavioral neurology at the UCSF Memory and Aging Center (MAC). He is a Professor of Neurology at the MAC.

Dr. Geschwind evaluates new patients in the MAC clinic and participates in the continued management and care for these patients in the continuity clinic. He is active in the training of medical students, residents and neurobehavior and other fellows at UCSF. Dr. Geschwind teaches national courses, and lectures both nationally and internationally, on dementia including rapidly progressive dementias, such as prion diseases and antibody-mediated dementias. He has been a guest editor for the American Academy of Neurology (AAN) Continuum Dementia edition and has contributed to editions on dementia and infectious disease. He also served on the AAN’s committee for dementia criteria.

Dr. Geschwind’s primary research interest is the assessment, management and treatment of rapidly progressive dementias, including prion diseases such as Creutzfeldt-Jakob disease (CJD) and antibody-mediated encephalopathies. Dr. Geschwind helped establish a program for the assessment of rapidly progressive dementias at UCSF, the first of its kind in the country. He helped to run the first U.S. treatment study for CJD. He also has an active clinical and research interest in movement disorders, such as Huntington’s disease, spinocerebellar ataxia (SCA), multiple system atrophy (MSA), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), other parkinsonian dementias and neurogenetic disorders. Dr. Geschwind is also very interested in adult-onset leukoencephalopathies, including the neurogenetic disorder Cerebral Autosomal Dominant Arteriopathy Subcortical Infarcts and Leukoencephalopathy (CADASIL). He also was the site investigator for a treatment trial for patients with CADASIL and follows a large cohort of patients with CADASIL.

Dr. Geschwind also directs (with his colleague Dr. Alexandra Nelson) the MAC Huntington’s Disease (HD) Center, which has been designated a Huntington’s Disease Society of America Center of Excellence. He is an active investigator for several HD, SCA and MSA observational and/or interventional studies. He co-directs the UCSF MAC Autoimmune Encephalopathy Clinic in which patients with suspected or known antibody-mediated encephalopathies are evaluated and managed.


Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.

The Lancet. Neurology

Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, Green A, Haïk S, Kovacs GG, Ladogana A, Llorens F, Mead S, Nishida N, Pal S, Parchi P, Pocchiari M, Satoh K, Zanusso G, Zerr I

Multimodal MRI staging for tracking progression and clinical-imaging correlation in sporadic Creutzfeldt-Jakob disease.

NeuroImage. Clinical

Sacco S, Paoletti M, Staffaroni AM, Kang H, Rojas J, Marx G, Goh SY, Luisa Mandelli M, Allen IE, Kramer JH, Bastianello S, Henry RG, Rosen HJ, Caverzasi E, Geschwind MD

Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects.

Neurology(R) neuroimmunology & neuroinflammation

Landa J, Guasp M, Petit-Pedrol M, Martínez-Hernández E, Planagumà J, Saiz A, Ruiz-García R, García-Fernández L, Verschuuren J, Saunders-Pullman R, Ramirez-Gómez L, Geschwind MD, Dalmau J, Sabater L, Graus F

Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.

Annals of clinical and translational neurology

Orrú CD, Groveman BR, Foutz A, Bongianni M, Cardone F, McKenzie N, Culeux A, Poleggi A, Grznarova K, Perra D, Fiorini M, Liu X, Ladogana A, Sbriccoli M, Hughson AG, Haïk S, Green AJ, Geschwind MD, Pocchiari M, Safar JG, Zanusso G, Caughey B

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.

The Lancet. Neurology

Jones E, Hummerich H, Viré E, Uphill J, Dimitriadis A, Speedy H, Campbell T, Norsworthy P, Quinn L, Whitfield J, Linehan J, Jaunmuktane Z, Brandner S, Jat P, Nihat A, How Mok T, Ahmed P, Collins S, Stehmann C, Sarros S, Kovacs GG, Geschwind MD, Golubjatnikov A, Frontzek K, Budka H, Aguzzi A, Karamujic-Comic H, van der Lee SJ, Ibrahim-Verbaas CA, van Duijn CM, Sikorska B, Golanska E, Liberski PP, Calero M, Calero O, Sanchez-Juan P, Salas A, Martinón-Torres F, Bouaziz-Amar E, Haïk S, Laplanche JL, Brandel JP, Amouyel P, Lambert JC, Parchi P, Bartoletti-Stella A, Capellari S, Poleggi A, Ladogana A, Pocchiari M, Aneli S, Matullo G, Knight R, Zafar S, Zerr I, Booth S, Coulthart MB, Jansen GH, Glisic K, Blevins J, Gambetti P, Safar J, Appleby B, Collinge J, Mead S

Baseline neuropsychological profiles in prion disease predict survival time.

Annals of clinical and translational neurology

Sundaram SE, Staffaroni AM, Walker NC, Casaletto KB, Casey M, Golubjatnikov A, Metcalf S, O'Leary K, Wong K, Benisano K, Forner S, Gonzalez Catalan M, Allen IE, Rosen HJ, Kramer JH, Geschwind MD

Anti-gamma-aminobutyric acid receptor type A encephalitis: a review.

Current opinion in neurology

Guo CY, Gelfand JM, Geschwind MD

Dysphagia in spinocerebellar ataxias type 1, 2, 3 and 6.

Journal of the neurological sciences

Yang CY, Lai RY, Amokrane N, Lin CY, Figueroa KP, Pulst SM, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Shakkottai VG, Rosenthal LS, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Troche MS, Kuo SH

The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3.

Parkinsonism & related disorders

Gan SR, Figueroa KP, Xu HL, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind MD, Xia G, Subramony SH, Rosenthal L, Ashizawa T, Pulst SM, Wang N, Kuo SH

Bilateral basal ganglia infarcts presenting as rapid onset cognitive and behavioral disturbance.


Hellmuth J, Casaletto K, Cuneo R, Possin KL, Dillon W, Geschwind MD

Intrathecal B-cell activation in LGI1 antibody encephalitis.

Neurology(R) neuroimmunology & neuroinflammation

Lehmann-Horn K, Irani SR, Wang S, Palanichamy A, Jahn S, Greenfield AL, Dandekar R, Lepennetier G, Michael S, Gelfand JM, Geschwind MD, Wilson MR, Zamvil SS, von Büdingen HC

Dementia assessment and management in primary care settings: a survey of current provider practices in the United States.

BMC health services research

Bernstein A, Rogers KM, Possin KL, Steele NZR, Ritchie CS, Kramer JH, Geschwind M, Higgins JJ, Wohlgemuth J, Pesano R, Miller BL, Rankin KP

A Diagnostic Ceiling for Exome Sequencing in Cerebellar Ataxia and Related Neurological Disorders.

Human mutation

Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions.

Acta neuropathologica

Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ

An Opioid-Related Amnestic Syndrome With Persistent Effects on Hippocampal Structure and Function.

The Journal of neuropsychiatry and clinical neurosciences

Butler PM, Barash JA, Casaletto KB, Cotter DL, La Joie R, Geschwind MD, Rosen HJ, Kramer JH, Miller BL

Age at onset in genetic prion disease and the design of preventive clinical trials.


Minikel EV, Vallabh SM, Orseth MC, Brandel JP, Haïk S, Laplanche JL, Zerr I, Parchi P, Capellari S, Safar J, Kenny J, Fong JC, Takada LT, Ponto C, Hermann P, Knipper T, Stehmann C, Kitamoto T, Ae R, Hamaguchi T, Sanjo N, Tsukamoto T, Mizusawa H, Collins SJ, Chiesa R, Roiter I, de Pedro-Cuesta J, Calero M, Geschwind MD, Yamada M, Nakamura Y, Mead S

Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor.

Cerebellum (London, England)

Lai RY, Tomishon D, Figueroa KP, Pulst SM, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease.

JAMA neurology

Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD

GABAA receptor autoimmunity: A multicenter experience.

Neurology(R) neuroimmunology & neuroinflammation

O'Connor K, Waters P, Komorowski L, Zekeridou A, Guo CY, Mgbachi VC, Probst C, Mindorf S, Teegen B, Gelfand JM, Geschwind MD, Lennon V, Pittock SJ, McKeon A

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development.

Proceedings of the National Academy of Sciences of the United States of America

Vallabh SM, Nobuhara CK, Llorens F, Zerr I, Parchi P, Capellari S, Kuhn E, Klickstein J, Safar JG, Nery FC, Swoboda KJ, Geschwind MD, Zetterberg H, Arnold SE, Minikel EV, Schreiber SL

Early cortical and late striatal diffusion restriction on 3T MRI in a long-lived sporadic creutzfeldt-jakob disease case.

Journal of magnetic resonance imaging : JMRI

Vitali P, Palesi F, Cotta Ramusino M, Pan M, Costa A, Gandini Wheeler-Kingshott C, Ceroni M, Micieli G, Anzalone N, Giaccone G, Tagliavini F, Geschwind M

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.


Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ

Prion Diseases.

Neurologic clinics

Tee BL, Longoria Ibarrola EM, Geschwind MD

Distinct HLA associations of LGI1 and CASPR2-antibody diseases.

Brain : a journal of neurology

Binks S, Varley J, Lee W, Makuch M, Elliott K, Gelfand JM, Jacob S, Leite MI, Maddison P, Chen M, Geschwind MD, Grant E, Sen A, Waters P, McCormack M, Cavalleri GL, Barnardo M, Knight JC, Irani SR

Cerebrospinal Fluid Total Prion Protein in the Spectrum of Prion Diseases.

Molecular neurobiology

Villar-Piqué A, Schmitz M, Lachmann I, Karch A, Calero O, Stehmann C, Sarros S, Ladogana A, Poleggi A, Santana I, Ferrer I, Mitrova E, Žáková D, Pocchiari M, Baldeiras I, Calero M, Collins SJ, Geschwind MD, Sánchez-Valle R, Zerr I, Llorens F

Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F.

Neurology. Genetics

Shanbhag NM, Geschwind MD, DiGiovanna JJ, Groden C, Godfrey R, Yousefzadeh MJ, Wade EA, Niedernhofer LJ, Malicdan MCV, Kraemer KH, Gahl WA, Toro C

Genetic PrP Prion Diseases.

Cold Spring Harbor perspectives in biology

Kim MO, Takada LT, Wong K, Forner SA, Geschwind MD

Expanding the global prevalence of spinocerebellar ataxia type 42.

Neurology. Genetics

Ngo K, Aker M, Petty LE, Chen J, Cavalcanti F, Nelson AB, Hassin-Baer S, Geschwind MD, Perlman S, Italiano D, Laganà A, Cavallaro S, Coppola G, Below JE, Fogel BL

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.

Cold Spring Harbor perspectives in biology

Erkkinen MG, Kim MO, Geschwind MD

The importance of early immunotherapy in patients with faciobrachial dystonic seizures.

Brain : a journal of neurology

Thompson J, Bi M, Murchison AG, Makuch M, Bien CG, Chu K, Farooque P, Gelfand JM, Geschwind MD, Hirsch LJ, Somerville E, Lang B, Vincent A, Leite MI, Waters P, Irani SR

Prion disease.

Handbook of clinical neurology

Takada LT, Kim MO, Metcalf S, Gala II, Geschwind MD

Neuroimaging in Dementia.

Seminars in neurology

Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD

C9orf72 repeat expansions as genetic modifiers for depression in spinocerebellar ataxias.

Movement disorders : official journal of the Movement Disorder Society

Figueroa KP, Gan SR, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Pulst SM, Kuo SH

Dystonia and ataxia progression in spinocerebellar ataxias.

Parkinsonism & related disorders

Kuo PH, Gan SR, Wang J, Lo RY, Figueroa KP, Tomishon D, Pulst SM, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind MD, Xia G, Subramony SH, Ashizawa T, Kuo SH

Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias.

Tremor and other hyperkinetic movements (New York, N.Y.)

Gan SR, Wang J, Figueroa KP, Pulst SM, Tomishon D, Lee D, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind MD, Xia G, Subramony SH, Ashizawa T, Kuo SH

Surface-based morphometry reveals caudate subnuclear structural damage in patients with premotor Huntington disease.

Brain imaging and behavior

Kim H, Kim JH, Possin KL, Winer J, Geschwind MD, Xu D, Hess CP

Mass Confusion.

Journal of hospital medicine

Abad CL, Dhaliwal G, Geschwind MD, Saint S, Safdar N

The Initial Symptom and Motor Progression in Spinocerebellar Ataxias.

Cerebellum (London, England)

Luo L, Wang J, Lo RY, Figueroa KP, Pulst SM, Kuo PH, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH

Precipitous Deterioration of Motor Function, Cognition, and Behavior.

JAMA neurology

Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD

Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.


Possin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH

Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy.

Journal of Alzheimer's disease : JAD

Fong JC, Rojas JC, Bang J, Legati A, Rankin KP, Forner S, Miller ZA, Karydas AM, Coppola G, Grouse CK, Ralph J, Miller BL, Geschwind MD

Genetic prion disease: Experience of a rapidly progressive dementia center in the United States and a review of the literature.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Takada LT, Kim MO, Cleveland RW, Wong K, Forner SA, Gala II, Fong JC, Geschwind MD

A case cluster of variant Creutzfeldt-Jakob disease linked to the Kingdom of Saudi Arabia.

Brain : a journal of neurology

Coulthart MB, Geschwind MD, Qureshi S, Phielipp N, Demarsh A, Abrams JY, Belay E, Gambetti P, Jansen GH, Lang AE, Schonberger LB


Seminars in neurology

Ljubenkov PA, Geschwind MD

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.

Stem cell reports

Biswas MHU, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB

HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD).

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Carlozzi NE, Schilling SG, Lai JS, Paulsen JS, Hahn EA, Perlmutter JS, Ross CA, Downing NR, Kratz AL, McCormack MK, Nance MA, Quaid KA, Stout JC, Gershon RC, Ready RE, Miner JA, Barton SK, Perlman SL, Rao SM, Frank S, Shoulson I, Marin H, Geschwind MD, Dayalu P, Goodnight SM, Cella D

Rapidly Progressive Dementia.

Continuum (Minneapolis, Minn.)

Geschwind MD

A clinical approach to diagnosis of autoimmune encephalitis.

The Lancet. Neurology

Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J

Creutzfeldt-Jakob Disease-Like Periodic Sharp Wave Complexes in Voltage-Gated Potassium Channel-Complex Antibodies Encephalitis: A Case Report.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

Savard M, Irani SR, Guillemette A, Gosselin-Lefebvre S, Geschwind M, Jansen GH, Gould PV, Laforce R

Prion Diseases.

Continuum (Minneapolis, Minn.)

Geschwind MD

Depression and clinical progression in spinocerebellar ataxias.

Parkinsonism & related disorders

Lo RY, Figueroa KP, Pulst SM, Perlman S, Wilmot G, Gomez C, Schmahmann J, Paulson H, Shakkottai VG, Ying S, Zesiewicz T, Bushara K, Geschwind M, Xia G, Yu JT, Lee LE, Ashizawa T, Subramony SH, Kuo SH

Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.

Journal of neuropathology and experimental neurology

Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, DeArmond B, DeArmond SJ

Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation.

Annals of neurology

Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB

Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis.

Journal of neuroimmunology

Ng AS, Kramer J, Centurion A, Dalmau J, Huang E, Cotter JA, Geschwind MD

Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone.

Acta neuropathologica communications

Cali I, Miller CJ, Parisi JE, Geschwind MD, Gambetti P, Schonberger LB

Clinical update of Jakob-Creutzfeldt disease.

Current opinion in neurology

Kim MO, Geschwind MD

Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.


Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J

Comparing CSF biomarkers and brain MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease.

Neurology. Clinical practice

Forner SA, Takada LT, Bettcher BM, Lobach IV, Tartaglia MC, Torres-Chae C, Haman A, Thai J, Vitali P, Neuhaus J, Bostrom A, Miller BL, Rosen HJ, Geschwind MD

Metabolic disorders with clinical and radiologic features of sporadic Creutzfeldt-Jakob disease.

Neurology. Clinical practice

Rosenbloom MH, Tartaglia MC, Forner SA, Wong KK, Kuo A, Johnson DY, Colacurcio V, Andrews BD, Miller BL, DeArmond SJ, Geschwind MD

The active intrathecal B-cell response in LGI1-antibody encephalitis.

Lancet (London, England)

Irani SR, Lehmann-Horn K, Geschwind M, Wang S, Vincent A, von Büdingen HC

Vascular risk factors and clinical progression in spinocerebellar ataxias.

Tremor and other hyperkinetic movements (New York, N.Y.)

Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, Gomez CM, Schmahmann J, Paulson H, Shakkottai VG, Ying SH, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH

Whipple's disease masquerades as dementia with Lewy bodies.

Alzheimer disease and associated disorders

Hurth K, Tarawneh R, Ghoshal N, Benzinger TLS, Clifford DB, Geschwind M, Morris JC, Galvin JE, Schmidt RE, Cairns NJ

Coenzyme Q10 and spinocerebellar ataxias.

Movement disorders : official journal of the Movement Disorder Society

Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, Gomez C, Schmahmann J, Paulson H, Shakkottai VG, Ying S, Zesiewicz T, Bushara K, Geschwind M, Xia G, Subramony SH, Ashizawa T, Kuo SH

White matter involvement in sporadic Creutzfeldt-Jakob disease.

Brain : a journal of neurology

Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG

Ascertainment bias causes false signal of anticipation in genetic prion disease.

American journal of human genetics

Minikel EV, Zerr I, Collins SJ, Ponto C, Boyd A, Klug G, Karch A, Kenny J, Collinge J, Takada LT, Forner S, Fong JC, Mead S, Geschwind MD

Latent NOTCH3 epitopes unmasked in CADASIL and regulated by protein redox state.

Brain research

Zhang X, Lee SJ, Young KZ, Josephson DA, Geschwind MD, Wang MM

Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy.

JAMA neurology

Irani SR, Gelfand JM, Bettcher BM, Singhal NS, Geschwind MD

More than memory impairment in voltage-gated potassium channel complex encephalopathy.

European journal of neurology

Bettcher BM, Gelfand JM, Irani SR, Neuhaus J, Forner S, Hess CP, Geschwind MD

Quantitative 7T phase imaging in premanifest Huntington disease.

AJNR. American journal of neuroradiology

Apple AC, Possin KL, Satris G, Johnson E, Lupo JM, Jakary A, Wong K, Kelley DA, Kang GA, Sha SJ, Kramer JH, Geschwind MD, Nelson SJ, Hess CP

Preimplantation genetic diagnosis (PGD) for genetic prion disorder due to F198S mutation in the PRNP gene.

JAMA neurology

Uflacker A, Doraiswamy PM, Rechitsky S, See T, Geschwind M, Tur-Kaspa I

An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy.

PLoS genetics

Li Y, Chen JA, Sears RL, Gao F, Klein ED, Karydas A, Geschwind MD, Rosen HJ, Boxer AL, Guo W, Pellegrini M, Horvath S, Miller BL, Geschwind DH, Coppola G

Application of quantitative DTI metrics in sporadic CJD.

NeuroImage. Clinical

Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD

Executive functions in premanifest Huntington's disease.

Movement disorders : official journal of the Movement Disorder Society

You SC, Geschwind MD, Sha SJ, Apple A, Satris G, Wood KA, Johnson ET, Gooblar J, Feuerstein JS, Finkbeiner S, Kang GA, Miller BL, Hess CP, Kramer JH, Possin KL

Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases.

Acta neuropathologica communications

Kim MO, Cali I, Oehler A, Fong JC, Wong K, See T, Katz JS, Gambetti P, Bettcher BM, Dearmond SJ, Geschwind MD

Prion diseases.

Seminars in neurology

Takada LT, Geschwind MD

Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; a prospective observational study.

Orphanet journal of rare diseases

Ashizawa T, Figueroa KP, Perlman SL, Gomez CM, Wilmot GR, Schmahmann JD, Ying SH, Zesiewicz TA, Paulson HL, Shakkottai VG, Bushara KO, Kuo SH, Geschwind MD, Xia G, Mazzoni P, Krischer JP, Cuthbertson D, Holbert AR, Ferguson JH, Pulst SM, Subramony SH

Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.


Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL

Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease.

Alzheimer disease and associated disorders

Lee SE, Tartaglia MC, Yener G, Genç S, Seeley WW, Sanchez-Juan P, Moreno F, Mendez MF, Klein E, Rademakers R, López de Munain A, Combarros O, Kramer JH, Kenet RO, Boxer AL, Geschwind MD, Gorno-Tempini ML, Karydas AM, Rabinovici GD, Coppola G, Geschwind DH, Miller BL

Seizures and epileptiform activity in the early stages of Alzheimer disease.

JAMA neurology

Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L

Ethics in prion disease.

Progress in neurobiology

Bechtel K, Geschwind MD

Refining the diagnosis of Huntington disease: the PREDICT-HD study.

Frontiers in aging neuroscience

Biglan KM, Zhang Y, Long JD, Geschwind M, Kang GA, Killoran A, Lu W, McCusker E, Mills JA, Raymond LA, Testa C, Wojcieszek J, Paulsen JS

Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.

JAMA neurology

Johnson DY, Dunkelberger DL, Henry M, Haman A, Greicius MD, Wong K, DeArmond SJ, Miller BL, Gorno-Tempini ML, Geschwind MD

Differential diagnosis of Jakob-Creutzfeldt disease.

Archives of neurology

Paterson RW, Torres-Chae CC, Kuo AL, Ando T, Nguyen EA, Wong K, DeArmond SJ, Haman A, Garcia P, Johnson DY, Miller BL, Geschwind MD

Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.

Cell reports

Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB

Diagnosis and treatment of rapidly progressive dementias.

Neurology. Clinical practice

Paterson RW, Takada LT, Geschwind MD

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Human molecular genetics

Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA

Clinical overlap between Jakob-Creutzfeldt disease and Lewy body disease.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Tartaglia MC, Johnson DY, Thai JN, Cattaruzza T, Wong K, Garcia P, Dearmond SJ, Miller BL, Geschwind MD

Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of (18) F-FDG PET.

European journal of neurology

Kim EJ, Cho SS, Jeong BH, Kim YS, Seo SW, Na DL, Geschwind MD, Jeong Y

Thorough work-up and new diagnostic criteria needed for CJD.

Nature reviews. Neurology

Perry DC, Geschwind MD

Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria.

Nature genetics

Sloan JL, Johnston JJ, Manoli I, Chandler RJ, Krause C, Carrillo-Carrasco N, Chandrasekaran SD, Sysol JR, O'Brien K, Hauser NS, Sapp JC, Dorward HM, Huizing M

Clinicopathological correlations in corticobasal degeneration.

Annals of neurology

Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ, Huang EJ, Trojanowski JQ, Growdon ME, Jang JY, Sidhu M, See TM, Karydas AM, Gorno-Tempini ML, Boxer AL, Weiner MW, Geschwind MD, Rankin KP, Miller BL

Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias.


Vitali P, Maccagnano E, Caverzasi E, Henry RG, Haman A, Torres-Chae C, Johnson DY, Miller BL, Geschwind MD

Pathologic evidence that the T188R mutation in PRNP is associated with prion disease.

Journal of neuropathology and experimental neurology

Tartaglia MC, Thai JN, See T, Kuo A, Harbaugh R, Raudabaugh B, Cali I, Sattavat M, Sanchez H, DeArmond SJ, Geschwind MD

Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.

Annals of neurology

Zou WQ, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JP, Castellani R, Notari S, Crain B, Schmidt RE, Geschwind M, Dearmond SJ, Cairns NJ, Dickson D, Honig L, Torres JM, Mastrianni J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen M, Perry G, Kong Q, Parchi P, Tagliavini F, Gambetti P

De novo prions.

F1000 biology reports

Benetti F, Geschwind MD, Legname G

Familial Creutzfeldt-Jakob disease with V180I mutation.

Journal of Korean medical science

Yang TI, Jung DS, Ahn BY, Jeong BH, Cho HJ, Kim YS, Na DL, Geschwind MD, Kim EJ

Are you related to "the Geschwind?".

Neuropsychology review

Geschwind MD

A randomized, placebo-controlled trial of latrepirdine in Huntington disease.

Archives of neurology

Kieburtz K, McDermott MP, Voss TS, Corey-Bloom J, Deuel LM, Dorsey ER, Factor S, Geschwind MD, Hodgeman K, Kayson E, Noonberg S, Pourfar M, Rabinowitz K, Ravina B, Sanchez-Ramos J, Seely L, Walker F, Feigin A

Immunologically mediated dementias.

Current neurology and neuroscience reports

Rosenbloom MH, Smith S, Akdal G, Geschwind MD

Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease.

Laboratory investigation; a journal of technical methods and pathology

Choi EM, Geschwind MD, Deering C, Pomeroy K, Kuo A, Miller BL, Safar JG, Prusiner SB

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location.

Annals of neurology

Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J

Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease.

Alzheimer disease and associated disorders

Geschwind MD, Potter CA, Sattavat M, Garcia PA, Rosen HJ, Miller BL, DeArmond SJ

Neuroimaging in dementia.

Seminars in neurology

Vitali P, Migliaccio R, Agosta F, Rosen HJ, Geschwind MD

Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease.

Archives of neurology

Geschwind MD, Tan KM, Lennon VA, Barajas RF, Haman A, Klein CJ, Josephson SA, Pittock SJ

Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series.

Brain : a journal of neurology

Webb TE, Poulter M, Beck J, Uphill J, Adamson G, Campbell T, Linehan J, Powell C, Brandner S, Pal S, Siddique D, Wadsworth JD, Joiner S, Alner K, Petersen C, Hampson S, Rhymes C, Treacy C, Storey E, Geschwind MD, Nemeth AH, Wroe S, Collinge J, Mead S

Creutzfeldt-Jakob disease in recipients of corneal transplants.


Maddox RA, Belay ED, Curns AT, Zou WQ, Nowicki S, Lembach RG, Geschwind MD, Haman A, Shinozaki N, Nakamura Y, Borer MJ, Schonberger LB

Rapidly progressive dementia.

Annals of neurology

Geschwind MD, Shu H, Haman A, Sejvar JJ, Miller BL

A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia.

Nature clinical practice. Neurology

Valcour V, Haman A, Cornes S, Lawall C, Parsa AT, Glaser C, Yagi S, Tihan T, Bhatnagar J, Geschwind M

A 54-year-old man with slowness of movement and confusion.


Geschwind MD, Josephs KA, Parisi JE, Keegan BM

Rapidly progressive dementia.

Neurologic clinics

Geschwind MD, Haman A, Miller BL

Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease.


Boxer AL, Rabinovici GD, Kepe V, Goldman J, Furst AJ, Huang SC, Baker SL, O'neil JP, Chui H, Geschwind MD, Small GW, Barrio JR, Jagust W, Miller BL

Autoimmune encephalopathies.

The neurologist

Vernino S, Geschwind M, Boeve B

The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementia.

Journal of neurosurgery

Josephson SA, Papanastassiou AM, Berger MS, Barbaro NM, McDermott MW, Hilton JF, Miller BL, Geschwind MD

Human prions and plasma lipoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB

Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.

Clinical neurology and neurosurgery

Chang CC, Eggers SD, Johnson JK, Haman A, Miller BL, Geschwind MD

Human growth hormone-related iatrogenic Creutzfeldt-Jakob disease with abnormal imaging.

Archives of neurology

Lewis AM, Yu M, DeArmond SJ, Dillon WP, Miller BL, Geschwind MD

First symptom in sporadic Creutzfeldt-Jakob disease.


Rabinovici GD, Wang PN, Levin J, Cook L, Pravdin M, Davis J, DeArmond SJ, Barbaro NM, Martindale J, Miller BL, Geschwind MD

Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy.

Archives of neurology

Boxer AL, Geschwind MD, Belfor N, Gorno-Tempini ML, Schauer GF, Miller BL, Weiner MW, Rosen HJ

Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis.

AJNR. American journal of neuroradiology

Young GS, Geschwind MD, Fischbein NJ, Martindale JL, Henry RG, Liu S, Lu Y, Wong S, Liu H, Miller BL, Dillon WP

Diagnosis of human prion disease.

Proceedings of the National Academy of Sciences of the United States of America

Safar JG, Geschwind MD, Deering C, Didorenko S, Sattavat M, Sanchez H, Serban A, Vey M, Baron H, Giles K, Miller BL, Dearmond SJ, Prusiner SB

When sporadic disease is not sporadic: the potential for genetic etiology.

Archives of neurology

Goldman JS, Miller BL, Safar J, de Tourreil S, Martindale JL, Prusiner SB, Geschwind MD

Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.

Archives of neurology

Geschwind MD, Martindale J, Miller D, DeArmond SJ, Uyehara-Lock J, Gaskin D, Kramer JH, Barbaro NM, Miller BL

Psychiatric and neuroimaging findings in Creutzfeldt-Jakob disease.

Current psychiatry reports

Martindale JL, Geschwind MD, Miller BL

Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease.

Archives of neurology

Martindale J, Geschwind MD, De Armond S, Young G, Dillon WP, Henry R, Uyehara-Lock JH, Gaskin DA, Miller BL

Presenile dementia syndromes: an update on taxonomy and diagnosis.

Journal of neurology, neurosurgery, and psychiatry

Greicius MD, Geschwind MD, Miller BL

Cerebellar top-of-the-basilar syndrome.

Clinical neurology and neurosurgery

Silverman IE, Geschwind MD, Vornov JJ

Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons.

Molecular and cellular neurosciences

Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F

Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices.

Journal of neuroscience methods

Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff HJ, Bergold PJ

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

Proceedings of the National Academy of Sciences of the United States of America

Federoff HJ, Geschwind MD, Geller AI, Kessler JA