Aimee Kao, MD, PhD

Associate Professor
Neurology
+1 415 502-7123
Fields of Interest: 

Aimee Kao, MD, PhD, is an Associate Professor of Neurology at the University of California, San Francisco. She directs the UCSF Tau Consortium Human Fibroblast and Induced Pluripotent Stem Cell (iPSC) Bank and leads the UCSF Alzheimer Disease Research Center (ADRC) Neurodegenerative Disease Biomarker Core. Dr. Kao’s clinical expertise includes the diagnosis and treatment of Alzheimer’s disease, vascular dementia and frontotemporal lobar degeneration. Her basic science laboratory studies how age, stress and pH changes affect protein homeostasis and contribute to sporadic and familial neurodegenerative disorders. She has received the Paul G. Allen Family Foundation Distinguished Investigator Award in Neurodegenerative Diseases and the Glenn Award for Research in the Biological Mechanisms of Aging.

Publications: 

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.

Human molecular genetics

Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW

Tauopathy-Associated PERK Alleles are Functional Hypomorphs that Increase Neuronal Vulnerability to ER Stress.

Human molecular genetics

Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AS, Litvan I, Lin JH

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.

Scientific reports

Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.

Acta neuropathologica

Olney NT, Alquezar C, Ramos EM, Nana AL, Fong JC, Karydas AM, Taylor JB, Stephens ML, Argouarch AR, Van Berlo VA, Dokuru DR, Sherr EH, Jicha GA, Dillon WP, Desikan RS, De May M, Seeley WW, Coppola G, Miller BL, Kao AW

Progranulin, lysosomal regulation and neurodegenerative disease.

Nature reviews. Neuroscience

Kao AW, McKay A, Singh PP, Brunet A, Huang EJ

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Alzheimer's & dementia (Amsterdam, Netherlands)

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH

The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW

A shift to organismal stress resistance in programmed cell death mutants.

PLoS genetics

Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, Weiberth KF, Gao F, Coppola G, Kenyon C, Kao AW

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.

Proceedings of the National Academy of Sciences of the United States of America

Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C

Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.

Alzheimer disease and associated disorders

Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL

Chemokine receptors, neural progenitor cells, and the AIDS dementia complex.

The Journal of infectious diseases

Kao AW, Price RW

Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes.

American journal of physiology. Endocrinology and metabolism

Kao AW, Yang C, Pessin JE

Dynamin is required for recombinant adeno-associated virus type 2 infection.

Journal of virology

Duan D, Li Q, Kao AW, Yue Y, Pessin JE, Engelhardt JF

Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4.

The Journal of biological chemistry

Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism.

The Journal of biological chemistry

Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, Birnbaum MJ

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.

The Journal of biological chemistry

Okada S, Kao AW, Ceresa BP, Blaikie P, Margolis B, Pessin JE

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation.

The Journal of biological chemistry

Waters SB, Chen D, Kao AW, Okada S, Holt KH, Pessin JE

Evidence for myosin motors on organelles in squid axoplasm.

Proceedings of the National Academy of Sciences of the United States of America

Bearer EL, DeGiorgis JA, Bodner RA, Kao AW, Reese TS