Alexander Ehrenberg

Staff Research Associate
Fields of Interest: 

Alex started at UCSF in Spring 2012 as an intern under Dr. Pierre-Antoine Gourraud in the Multiple Sclerosis Genetics Research Lab. In 2013, he joined UCSF’s Memory and Aging Center as a staff member under the mentorship of neuropathologist, Prof. Lea T. Grinberg. There, he developed his interests in neurodegenerative diseases, specifically selective vulnerability and resilience at the early stages of Alzheimer’s disease and the neuropsychiatric manifestations associated with those stages. Beginning in 2015, he also joined Dr. Alan Shabel at UC Berkeley to study the neuroethological adaptations associated with wetland ecotone systems in Carnivora, focusing on African otters with field work in Malawi and the Democratic Republic of the Congo. Alex graduated from UC Berkeley in 2017 with a B.A. in integrative biology (evolution, ecology, and organismal biology division) and molecular and cellular biology (developmental genetics division).

In addition to continued work with Dr. Grinberg, Alex is now a Ph.D. student of Integrative Biology under the mentorship of Prof. Daniela Kaufer at the Helen Wills Neuroscience Institute at UC Berkeley where he studies the evolutionary foundations for selective vulnerability and resilience in neurodegenerative diseases.

www.ajehrenberg.com

Publications: 

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Brain : a journal of neurology

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D

Profound degeneration of wake-promoting neurons in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT

Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.

Acta neuropathologica

Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Journal of neuropathology and experimental neurology

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Ehrenberg AJ, Suemoto CK, de Paula França Resende E, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Neurobiology of aging

Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.

Neuropathology and applied neurobiology

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT