Claire Clelland, MD, PhD

Assistant Adjunct Professor
Fields of Interest: 

The Clelland laboratory aims to develop cures for dementia and related neurodegenerative diseases. She is focused on monogenic causes of frontotemporal dementia and amyotrophic lateral sclerosis, such as mutations in the C9orf72 gene. She and her team develop CRISPR gene editing approaches in relevant cell types derived from human iPSCs and are working to develop better cell model systems of disease.

Publications: 

Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro.

Biomaterials

Chun C, Smith AST, Kim H, Kamenz DS, Lee JH, Lee JB, Mack DL, Bothwell M, Clelland CD, Kim DH

Microglial microRNAs mediate sex-specific responses to tau pathology.

Nature neuroscience

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.

Proceedings of the National Academy of Sciences of the United States of America

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L

Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.

Neurobiology of Disease

Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA

Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache.

Cephalalgia : an international journal of headache

Clelland CD, Zheng Z, Kim W, Bari A, Pouratian N

Comprehensive review of stereotactic radiosurgery for medically and surgically refractory pituitary adenomas.

Surgical neurology international

Kim W, Clelland C, Yang I, Pouratian N

A functional role for adult hippocampal neurogenesis in spatial pattern separation.

Science (New York, N.Y.)

Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ

Cell therapy in Huntington disease.

Neurosurgical focus

Clelland CD, Barker RA, Watts C