Laura Mitic, PhD

Chief Scientific Officer, Bluefield Project to Cure FTD
+1 415 514-8043

Laura Mitic, PhD, is the Chief Scientific Officer at the Bluefield Project to Cure Frontotemporal Dementia. Dr. Mitic holds a BA degree from Northwestern University and a doctorate degree in cell biology from Yale University. She completed postdoctoral studies at the University of California, San Francisco. She and her husband live in San Francisco with their two children.

Publications: 

Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.

Neurology

Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, Pantelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Caroline V G, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL

Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency.

Frontiers in neurology

Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.

Alzheimer's & dementia (New York, N. Y.)

Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL

Prosaposin is a regulator of progranulin levels and oligomerization.

Nature communications

Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Alzheimer's & dementia (Amsterdam, Netherlands)

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH

Progranulin: at the interface of neurodegenerative and metabolic diseases.

Trends in endocrinology and metabolism: TEM

Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J

SUMOylation of claudin-2.

Annals of the New York Academy of Sciences

Van Itallie CM, Mitic LL, Anderson JM

Claudin-2 forms homodimers and is a component of a high molecular weight protein complex.

The Journal of biological chemistry

Van Itallie CM, Mitic LL, Anderson JM

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.

PLoS genetics

Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C

A Role for Autophagy Genes in the Extension of Lifespan by Dietary Restriction in C. elegans.

PLoS genetics

Malene Hansen, Abha Chandra, Laura L. Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon

Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4.

Protein science : a publication of the Protein Society

Mitic LL, Unger VM, Anderson JM

Occludin and Claudins.

Laura Mitic,Christina Van Itallie

Occludin localization at the tight junction requires the second extracellular loop.

The Journal of membrane biology

Medina R, Rahner C, Mitic LL, Anderson JM, Van Itallie CM

Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins.

American journal of physiology. Gastrointestinal and liver physiology

Mitic LL, Van Itallie CM, Anderson JM

Transmembrane proteins in the tight junction barrier.

Journal of the American Society of Nephrology : JASN

Fanning AS, Mitic LL, Anderson JM

Molecular architecture of tight junctions.

Annual review of physiology

Mitic LL, Anderson JM