Brandon Holmes, MD, PhD, is an assistant professor at the UCSF Edward and Pearl Fein Memory and Aging Center. His clinical and research expertise focuses on the underlying mechanisms of neurodegeneration and neuroinflammation, particularly how microglia—the innate immune cells of the central nervous system—modify their proteome in these contexts. Dr. Holmes completed his clinical fellowship at the Fein MAC and pursued postdoctoral research in the Department of Pharmaceutical Chemistry under James A. Wells, PhD. His laboratory continues to investigate the role of microglia in brain health and disease. Learn more about his research at holmeslab.ucsf.edu.
Dr. Holmes earned his bachelor’s degree in neuroscience from Oberlin College and his MD/PhD from Washington University in St. Louis. During his doctoral studies, he investigated the molecular mechanisms underlying the internalization and spread of tau aggregates between neurons, thereby contributing to the understanding of neurodegenerative diseases, such as Alzheimer’s disease. He completed his neurology residency at UCSF in 2021, where he deepened his commitment to addressing complex neurological conditions.
Dedicated to advancing the science of neurodegeneration, Dr. Holmes is passionate about translating research discoveries into improved clinical care for patients and families affected by memory and movement disorders. He is also actively involved in mentoring trainees, helping to foster the next generation of neurologists and neuroscientists.
Outside of work, Dr. Holmes enjoys spending time with his family, exploring the outdoors through hiking, playing drums, traveling, and mastering the art of barbecue.