Christine Walsh, PhD

Assistant Professor
+1 415 476-8676
Fields of Interest: 

Christine M. Walsh, PhD, received her BA degree in physiology from Trinity College Dublin, University of Dublin in Ireland. Dr. Walsh did her doctoral work at the University of Michigan studying the effects of REM sleep modulation on learning and memory. She also studied the neural correlates of cognitive aging. In 2011 Dr. Walsh joined the UCSF Memory and Aging Center where she has been studying sleep in both healthy older adults and in individuals with neurodegenerative diseases. Dr. Walsh is particularly interested in the contribution of sleep disturbance to cognitive decline.

Publications: 

REM sleep is associated with white matter integrity in cognitively healthy, older adults.

PloS one

Altendahl M, Cotter DL, Staffaroni AM, Wolf A, Mumford P, Cobigo Y, Casaletto K, Elahi F, Ruoff L, Javed S, Bettcher BM, Fox E, You M, Saloner R, Neylan TC, Kramer JH, Walsh CM

Profound degeneration of wake-promoting neurons in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT

EARLY DEGENERATION OF AROUSAL SYSTEM IN ALZHEIMER'S DISEASE MAY UNDERLIE SLEEP DISTURBANCES IN PRECOGNITIVE STAGES.

Alzheimer's & Dementia

Jun Yeop Oh, Rana Eser, Alex Ehrenberg, Dulce Morales, Cathrine Petersen, Jessica Kudlacek, Sara Rose Dunlop, Maria B. Mejia, Elisa de Paula França Resende, Celica Glenn Cosme, Panos Theofilas, William W. Seeley, Salvatore Spina, Christine Walsh, Thomas Neylan, Bruce L. Miller, Lea T. Grinberg

NEUROBIOLOGICAL BASIS OF SLEEP AND WAKE DYSFUNCTION IN AD AND OTHER TAUOPATHIES: THE ROLE OF THE NEUROMODULATORY SYSTEM.

Alzheimer's & Dementia

Lea T. Grinberg, Jun Yeop Oh, Alexander J. Ehrenberg, Rana Eser, Christine Walsh, Thomas Neylan

SLEEP-WAKE BEHAVIOR IN THE 4-REPEAT TAUOPATHY- PROGRESSIVE SUPRANUCLEAR PALSY.

Alzheimer's & Dementia

Thomas Neylan, Christine Walsh, Lea T. Grinberg

SLOW WAVE SLEEP ENHANCERS AS A POTENTIAL THERAPEUTIC APPROACH IN DELAYING COGNITIVE DECLINE IN ALZHEIMER'S DISEASE: THE TRAZODONE PARADIGM.

Alzheimer's & Dementia

Elissaios Karageorgiou, Alice La, Andrew Krystal, Christine Walsh, Thomas Neylan, Keith A. Vossel, Kristine Yaffe, Bruce L. Miller

0303 Neurobiological Basis of Sleep Disturbances in Tauopathies: Human Wake-Promoting Neurons Degenerate More in Alzheimer’s Disease.

Sleep

Jun Oh, Rana A Eser, Alexander J Ehrenberg, Dulce Morales, Cathrine Petersen, Panos Theofilas, Elisa Resende, Celica Cosme, William W Seeley, Salvatore Spina, Christine M Walsh, Thomas C Neylan, Bruce L Miller, Jackson C Bittencourt, Lea T Grinberg

Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.

Journal of Alzheimer's disease : JAD

La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E

The role of co-neurotransmitters in sleep and wake regulation.

Molecular psychiatry

Oh J, Petersen C, Walsh CM, Bittencourt JC, Neylan TC, Grinberg LT

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Journal of neuropathology and experimental neurology

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT

Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy.

Sleep

Walsh CM, Ruoff L, Walker K, Emery A, Varbel J, Karageorgiou E, Luong PN, Mance I, Heuer HW, Boxer AL, Grinberg LT, Kramer JH, Miller BL, Neylan TC

INVESTIGATING THE SELECTIVE VULNERABILITY OF ALZHEIMER’S DISEASE IN FIVE SUBCORTICAL NUCLEI AS COMPARED TO FOUR REPEAT TAUOPATHIES.

Alzheimer's & Dementia

Rana April Eser, Alexander J. Ehrenberg, Cathrine Petersen, Maria B. Mejia, William W. Seeley, Christine Walsh, Thomas Neylan, Bruce L. Miller, Lea T. Grinberg

INVESTIGATING THE SELECTIVE VULNERABILITY OF ALZHEIMER’S DISEASE IN FIVE SUBCORTICAL NUCLEI AS COMPARED TO FOUR REPEAT TAUOPATHIES.

Alzheimer's & Dementia

Rana April Eser, Alexander J. Ehrenberg, Cathrine Petersen, Maria B. Mejia, William W. Seeley, Christine Walsh, Thomas Neylan, Bruce L. Miller, Lea T. Grinberg

TAU BURDEN IN OREXINERGIC WAKE-PROMOTING NEURONS IN ALZHEIMER'S DISEASE IN COMPARISON TO CORTICAL BASAL DEGENERATION AND PROGRESSIVE SUPRANUCLEAR PALSY: A NEUROPATHOLOGICAL IMPLICATION IN SLEEP DISTURBANCES.

Alzheimer's & Dementia

Jun Yeop Oh, Rana April Eser, Alexander J. Ehrenberg, Sara Rose Dunlop, Maria B. Mejia, Cathrine Petersen, Panos Theofilas, William W. Seeley, Christine Walsh, Thomas Neylan, Bruce L. Miller, Helmut Heinsen, Eduardo Alho, Lea T. Grinberg

Sleep Disorders and Dementia: From Basic Mechanisms to Clinical Decisions.

Psychiatric Annals

Elissaios Karageorgiou, Christine M. Walsh, Kristine Yaffe, Thomas C. Neylan, Bruce L. Miller

Rest-activity rhythm disruption in progressive supranuclear palsy.

Sleep medicine

Walsh CM, Ruoff L, Varbel J, Walker K, Grinberg LT, Boxer AL, Kramer JH, Miller BL, Neylan TC

Neuroanatomical substrates of executive functions: Beyond prefrontal structures.

Neuropsychologia

Bettcher BM, Mungas D, Patel N, Elofson J, Dutt S, Wynn M, Watson CL, Stephens M, Walsh CM, Kramer JH

Neuropsychiatric Symptoms Predict Functional Status in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

You SC, Walsh CM, Chiodo LA, Ketelle R, Miller BL, Kramer JH

Weaker circadian activity rhythms are associated with poorer executive function in older women.

Sleep

Walsh CM, Blackwell T, Tranah GJ, Stone KL, Ancoli-Israel S, Redline S, Paudel M, Kramer JH, Yaffe K

Interleukin-6, age, and corpus callosum integrity.

PloS one

Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH

Memory consolidation in aging and MCI after 1 week.

Neuropsychology

Walsh CM, Wilkins S, Bettcher BM, Butler CR, Miller BL, Kramer JH

Body mass and white matter integrity: the influence of vascular and inflammatory markers.

PloS one

Bettcher BM, Walsh CM, Watson C, Miller JW, Green R, Patel N, Miller BL, Neuhaus J, Yaffe K, Kramer JH

Body mass and white matter integrity: The role of vascular and inflammatory factors in healthy aging.

Alzheimer's & Dementia

Brianne Bettcher, Christine Walsh, Christa Watson, Joshua Miller, Ralph Green, Nihar Patel, Bruce Miller, Kristine Yaffe, Joel H. Kramer

Circadian activity rhythm patterns in nondemented older women and cognitive function 5 years later.

Alzheimer's & Dementia

Christine Walsh, Greg Tranah, Katie Stone, Terri Blackwell, Susan Redline, Misti Paudel, Sonia Ancoli-Israel, Joel H. Kramer, Kristine Yaffe

The young and the rest-less.

Sleep

Walsh CM, Poe GR